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Items: 1 to 20 of 133

1.

FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.

Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J, Guan Y.

Hepatology. 2014 May;59(5):1779-90. doi: 10.1002/hep.26945. Epub 2014 Mar 27.

PMID:
24806753
2.

Dapper1 attenuates hepatic gluconeogenesis and lipogenesis by activating PI3K/Akt signaling.

Kuang JR, Zhang ZH, Leng WL, Lei XT, Liang ZW.

Mol Cell Endocrinol. 2017 May 15;447:106-115. doi: 10.1016/j.mce.2017.02.028. Epub 2017 Feb 24.

PMID:
28237722
3.

Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice.

Wang C, Chen Z, Li S, Zhang Y, Jia S, Li J, Chi Y, Miao Y, Guan Y, Yang J.

Diabetes. 2014 Mar;63(3):947-59. doi: 10.2337/db13-1096. Epub 2013 Dec 2.

4.

NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.

Yang W, Wang J, Chen Z, Chen J, Meng Y, Chen L, Chang Y, Geng B, Sun L, Dou L, Li J, Guan Y, Cui Q, Yang J.

Diabetes. 2017 Jul;66(7):1819-1832. doi: 10.2337/db16-1172. Epub 2017 Apr 14.

PMID:
28411267
5.

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.

Liu TY, Shi CX, Gao R, Sun HJ, Xiong XQ, Ding L, Chen Q, Li YH, Wang JJ, Kang YM, Zhu GQ.

Clin Sci (Lond). 2015 Nov;129(10):839-50. doi: 10.1042/CS20150009. Epub 2015 Jul 13.

PMID:
26201094
6.

Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway.

Li J, Chi Y, Wang C, Wu J, Yang H, Zhang D, Zhu Y, Wang N, Yang J, Guan Y.

Hepatology. 2011 Jun;53(6):1906-16. doi: 10.1002/hep.24295. Epub 2011 May 2.

PMID:
21412813
7.

Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice.

Quan HY, Yuan HD, Jung MS, Ko SK, Park YG, Chung SH.

Int J Mol Med. 2012 Jan;29(1):73-80. doi: 10.3892/ijmm.2011.805. Epub 2011 Oct 3.

PMID:
21971952
8.

PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.

Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y.

Diabetes. 2013 Feb;62(2):444-56. doi: 10.2337/db12-0244. Epub 2012 Oct 18.

9.

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.

Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W, Liu Y.

Hepatology. 2009 Apr;49(4):1166-75. doi: 10.1002/hep.22774.

10.

APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.

Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A.

Cell Metab. 2009 May;9(5):417-27. doi: 10.1016/j.cmet.2009.03.013.

11.

Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.

Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B.

Biochem Pharmacol. 2014 Sep 1;91(1):74-86. doi: 10.1016/j.bcp.2014.07.002. Epub 2014 Jul 12.

PMID:
25026599
12.

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.

Li S, Brown MS, Goldstein JL.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6. doi: 10.1073/pnas.0914798107. Epub 2010 Feb 1.

13.

FAM3A is a target gene of peroxisome proliferator-activated receptor gamma.

Zhou Y, Jia S, Wang C, Chen Z, Chi Y, Li J, Xu G, Guan Y, Yang J.

Biochim Biophys Acta. 2013 Aug;1830(8):4160-70. doi: 10.1016/j.bbagen.2013.03.029. Epub 2013 Apr 3.

PMID:
23562554
14.

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis.

Svegliati-Baroni G, Saccomanno S, Rychlicki C, Agostinelli L, De Minicis S, Candelaresi C, Faraci G, Pacetti D, Vivarelli M, Nicolini D, Garelli P, Casini A, Manco M, Mingrone G, Risaliti A, Frega GN, Benedetti A, Gastaldelli A.

Liver Int. 2011 Oct;31(9):1285-97. doi: 10.1111/j.1478-3231.2011.02462.x. Epub 2011 Feb 15.

PMID:
21745271
15.

Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.

Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y, Kurihara H, Asano T.

J Biol Chem. 2005 Dec 23;280(51):42016-25. Epub 2005 Oct 21.

16.

Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB.

Yang M, Dai J, Jia Y, Suo L, Li S, Guo Y, Liu H, Li L, Yang G.

FEBS J. 2014 Jul;281(14):3193-205. doi: 10.1111/febs.12853. Epub 2014 Jun 17.

17.

Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.

Morino S, Kondo T, Sasaki K, Adachi H, Suico MA, Sekimoto E, Matsuda T, Shuto T, Araki E, Kai H.

PLoS One. 2008;3(12):e4068. doi: 10.1371/journal.pone.0004068. Epub 2008 Dec 30.

18.

Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.

Lee JM, Seo WY, Han HS, Oh KJ, Lee YS, Kim DK, Choi S, Choi BH, Harris RA, Lee CH, Koo SH, Choi HS.

Diabetes. 2016 Jan;65(1):62-73. doi: 10.2337/db15-0249. Epub 2015 Sep 4.

19.

Mouse KLF11 regulates hepatic lipid metabolism.

Zhang H, Chen Q, Yang M, Zhu B, Cui Y, Xue Y, Gong N, Cui A, Wang M, Shen L, Zhang S, Fang F, Chang Y.

J Hepatol. 2013 Apr;58(4):763-70. doi: 10.1016/j.jhep.2012.11.024. Epub 2012 Nov 23.

PMID:
23183531
20.

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.

Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, Lévy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A.

Hepatology. 2014 May;59(5):1803-15. doi: 10.1002/hep.26957. Epub 2014 Apr 1.

PMID:
24327268

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