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The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells.

Iovine B, Oliviero G, Garofalo M, Orefice M, Nocella F, Borbone N, Piccialli V, Centore R, Mazzone M, Piccialli G, Bevilacqua MA.

PLoS One. 2014 May 7;9(5):e96755. doi: 10.1371/journal.pone.0096755. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99739. PLoS One. 2014;9(8):e105664.


l-carnosine dipeptide overcomes acquired resistance to 5-fluorouracil in HT29 human colon cancer cells via downregulation of HIF1-alpha and induction of apoptosis.

Iovine B, Guardia F, Irace C, Bevilacqua MA.

Biochimie. 2016 Aug;127:196-204. doi: 10.1016/j.biochi.2016.05.010. Epub 2016 May 24.


Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.

Lee WH, Kim YW, Choi JH, Brooks SC 3rd, Lee MO, Kim SG.

Mol Cancer Ther. 2009 Oct;8(10):2791-802. doi: 10.1158/1535-7163.MCT-09-0420. Epub 2009 Sep 29.


Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α activation.

Jung KH, Lee JH, Thien Quach CH, Paik JY, Oh H, Park JW, Lee EJ, Moon SH, Lee KH.

J Nucl Med. 2013 Dec;54(12):2161-7. doi: 10.2967/jnumed.112.115436. Epub 2013 Nov 12.


Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells.

Lu Y, Wang B, Shi Q, Wang X, Wang D, Zhu L.

Sci Rep. 2016 Dec 16;6:39123. doi: 10.1038/srep39123.


TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention.

Yang X, Chen GT, Wang YQ, Xian S, Zhang L, Zhu SM, Pan F, Cheng YX.

Mol Med Rep. 2018 Feb;17(2):2229-2238. doi: 10.3892/mmr.2017.8108. Epub 2017 Nov 20.


SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.

Bell EL, Emerling BM, Ricoult SJ, Guarente L.

Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28.


Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells.

Chowdhury R, Godoy LC, Thiantanawat A, Trudel LJ, Deen WM, Wogan GN.

Chem Res Toxicol. 2012 Oct 15;25(10):2194-202. doi: 10.1021/tx300274a. Epub 2012 Sep 25.


Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1α via mTOR/4E-BP1 signaling pathways.

Ma J, Li J, Wang KS, Mi C, Piao LX, Xu GH, Li X, Lee JJ, Jin X.

Int Immunopharmacol. 2016 Oct;39:1-9. doi: 10.1016/j.intimp.2016.06.034. Epub 2016 Jul 6.


1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells.

Ben-Shoshan M, Amir S, Dang DT, Dang LH, Weisman Y, Mabjeesh NJ.

Mol Cancer Ther. 2007 Apr;6(4):1433-9.


HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein.

Chen J, Ding Z, Peng Y, Pan F, Li J, Zou L, Zhang Y, Liang H.

PLoS One. 2014 Jun 5;9(6):e98882. doi: 10.1371/journal.pone.0098882. eCollection 2014.


Apolipoprotein A-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.

Gao F, Chattopadhyay A, Navab M, Grijalva V, Su F, Fogelman AM, Reddy ST, Farias-Eisner R.

J Pharmacol Exp Ther. 2012 Aug;342(2):255-62. doi: 10.1124/jpet.112.191544. Epub 2012 Apr 25.


Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1α protein.

Sun Y, Wang H, Liu M, Lin F, Hua J.

Mol Med Rep. 2015 Mar;11(3):1975-81. doi: 10.3892/mmr.2014.2913. Epub 2014 Nov 10.


Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.

Han X, Sun S, Zhao M, Cheng X, Chen G, Lin S, Guan Y, Yu X.

PLoS One. 2014 Nov 10;9(11):e112470. doi: 10.1371/journal.pone.0112470. eCollection 2014.


Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma.

Zhou X, Chen J, Yi G, Deng M, Liu H, Liang M, Shi B, Fu X, Chen Y, Chen L, He Z, Wang J, Liu J.

Oncotarget. 2016 Jan 5;7(1):873-84. doi: 10.18632/oncotarget.6418.


Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway.

Wang H, Zhao L, Zhu LT, Wang Y, Pan D, Yao J, You QD, Guo QL.

Mol Carcinog. 2014 Feb;53 Suppl 1:E107-18. doi: 10.1002/mc.22052. Epub 2013 Jun 13.


Zinc finger protein 91 (ZFP91) activates HIF-1α via NF-κB/p65 to promote proliferation and tumorigenesis of colon cancer.

Ma J, Mi C, Wang KS, Lee JJ, Jin X.

Oncotarget. 2016 Jun 14;7(24):36551-36562. doi: 10.18632/oncotarget.9070.


The TNF-α/ROS/HIF-1-induced upregulation of FoxMI expression promotes HCC proliferation and resistance to apoptosis.

Xia L, Mo P, Huang W, Zhang L, Wang Y, Zhu H, Tian D, Liu J, Chen Z, Zhang Y, Chen Z, Hu H, Fan D, Nie Y, Wu K.

Carcinogenesis. 2012 Nov;33(11):2250-9. doi: 10.1093/carcin/bgs249. Epub 2012 Jul 25.


Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.

Li Y, Zhao X, Tang H, Zhong Z, Zhang L, Xu R, Li S, Wang Y.

Urol Int. 2012;88(1):95-101. doi: 10.1159/000331881. Epub 2011 Oct 25.


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