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Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo.

Judd LM, Menheniott TR, Ling H, Jackson CB, Howlett M, Kalantzis A, Priebe W, Giraud AS.

PLoS One. 2014 May 7;9(5):e95993. doi: 10.1371/journal.pone.0095993. eCollection 2014.


WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

Ferrajoli A, Faderl S, Van Q, Koch P, Harris D, Liu Z, Hazan-Halevy I, Wang Y, Kantarjian HM, Priebe W, Estrov Z.

Cancer Res. 2007 Dec 1;67(23):11291-9.


Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Yang F, Jove V, Buettner R, Xin H, Wu J, Wang Y, Nam S, Xu Y, Ara T, DeClerck YA, Seeger R, Yu H, Jove R.

Cancer Biol Ther. 2012 May;13(7):534-41. doi: 10.4161/cbt.19603. Epub 2012 May 1.


JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway.

Fang J, Chu L, Li C, Chen Y, Hu F, Zhang X, Zhao H, Liu Z, Xu Q.

Oncol Rep. 2015 Jan;33(1):494-502. doi: 10.3892/or.2014.3609. Epub 2014 Nov 14.


Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro.

Tang YJ, Sun ZL, Wu WG, Xing J, He YF, Xin DM, Han P.

Genet Mol Res. 2015 Mar 30;14(1):2450-60. doi: 10.4238/2015.March.30.3.


A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM.

Carcinogenesis. 2013 Dec;34(12):2918-28. doi: 10.1093/carcin/bgt255. Epub 2013 Jul 23.


On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.

Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S.

Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21.


OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells.

Kim MJ, Nam HJ, Kim HP, Han SW, Im SA, Kim TY, Oh DY, Bang YJ.

Cancer Lett. 2013 Jul 10;335(1):145-52. doi: 10.1016/j.canlet.2013.02.010. Epub 2013 Feb 10.


A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.

Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, Hess K, Conrad C, Madden T, Sawaya R, Kondo S, Priebe W, Kondo Y.

Oncogene. 2007 Apr 12;26(17):2435-44. Epub 2006 Oct 16.


Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro.

Zhu WQ, Wang J, Guo XF, Liu Z, Dong WG.

World J Gastroenterol. 2016 Apr 28;22(16):4149-59. doi: 10.3748/wjg.v22.i16.4149.


Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.

Yang F, Brown C, Buettner R, Hedvat M, Starr R, Scuto A, Schroeder A, Jensen M, Jove R.

Mol Cancer Ther. 2010 Apr;9(4):953-62. doi: 10.1158/1535-7163.MCT-09-0947. Epub 2010 Apr 6.


WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.

Honda S, Sadatomi D, Yamamura Y, Nakashioya K, Tanimura S, Takeda K.

Cancer Sci. 2017 Mar;108(3):520-527. doi: 10.1111/cas.13154.


STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats.

Xue ZJ, Shen L, Wang ZY, Hui SY, Huang YG, Ma C.

Brain Res. 2014 Oct 2;1583:79-88. doi: 10.1016/j.brainres.2014.07.015. Epub 2014 Jul 30.


Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation.

Daniel JM, Dutzmann J, Bielenberg W, Widmer-Teske R, Gündüz D, Hamm CW, Sedding DG.

Basic Res Cardiol. 2012 May;107(3):261. doi: 10.1007/s00395-012-0261-9. Epub 2012 Mar 15.


17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

Wang Y, Ma X, Yan S, Shen S, Zhu H, Gu Y, Wang H, Qin G, Yu Q.

Cancer Res. 2009 Sep 15;69(18):7302-10. doi: 10.1158/0008-5472.CAN-09-0462. Epub 2009 Aug 25.


Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer.

Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M.

Mol Cancer Ther. 2012 Feb;11(2):277-87. doi: 10.1158/1535-7163.MCT-11-0648. Epub 2011 Dec 27.


miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling.

Miao L, Liu K, Xie M, Xing Y, Xi T.

Cancer Immunol Immunother. 2014 Jul;63(7):699-711. doi: 10.1007/s00262-014-1550-y. Epub 2014 Apr 10.


STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo.

Zhou X, Ren Y, Liu A, Han L, Zhang K, Li S, Li P, Li P, Kang C, Wang X, Zhang L.

Oncol Rep. 2014 May;31(5):2173-80. doi: 10.3892/or.2014.3114. Epub 2014 Mar 27.


Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells.

Behera R, Kumar V, Lohite K, Karnik S, Kundu GC.

Carcinogenesis. 2010 Feb;31(2):192-200. doi: 10.1093/carcin/bgp289. Epub 2009 Nov 19.


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