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Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1.

Bu W, Pereira LM, Eckenhoff RG, Yuki K.

PLoS One. 2014 May 6;9(5):e96649. doi: 10.1371/journal.pone.0096649. eCollection 2014.


Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.

Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R.

Anesth Analg. 2013 Oct;117(4):803-11. doi: 10.1213/ANE.0b013e3182a00ae0. Epub 2013 Aug 19.


Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.

Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG.

FASEB J. 2012 Nov;26(11):4408-17. doi: 10.1096/fj.12-212746. Epub 2012 Jul 19.


Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.

Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M.

FASEB J. 2009 Aug;23(8):2735-40. doi: 10.1096/fj.09-129908. Epub 2009 Mar 30.


Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen.

Jung S, Yuki K.

J Immunotoxicol. 2016;13(2):148-56. doi: 10.3109/1547691X.2015.1019596. Epub 2015 Mar 9.


Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry.

Crump MP, Ceska TA, Spyracopoulos L, Henry A, Archibald SC, Alexander R, Taylor RJ, Findlow SC, O'Connell J, Robinson MK, Shock A.

Biochemistry. 2004 Mar 9;43(9):2394-404.


Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH.

Protein Sci. 2006 Feb;15(2):290-303. Epub 2005 Dec 29.


The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity.

Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M.

FASEB J. 2008 Dec;22(12):4109-16. doi: 10.1096/fj.08-113324. Epub 2008 Aug 15.


Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.

Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M.

Anesthesiology. 2010 Sep;113(3):600-9. doi: 10.1097/ALN.0b013e3181e89a77.


NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML Jr, Wilson AE, Fesik SW, Staunton DE.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5231-6.


Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.

Yuki K, Soriano SG, Shimaoka M.

Anesth Analg. 2011 Apr;112(4):830-8. doi: 10.1213/ANE.0b013e31820dcabb. Epub 2011 Mar 8.


Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3.

Landis RC, McDowall A, Holness CL, Littler AJ, Simmons DL, Hogg N.

J Cell Biol. 1994 Jul;126(2):529-37.


Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U.

J Mol Biol. 1999 Sep 10;292(1):1-9.


Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1).

Klickstein LB, York MR, Fougerolles AR, Springer TA.

J Biol Chem. 1996 Sep 27;271(39):23920-7.

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