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24801072,26583846,22693349,26070526,17360381,25577468,25150941,28300760,24842918,29849865,21051667,25472959,21810655,23357604,31106593,16731826,22518022,21956685,30047409,20739391,27073025,27368156,15490108,20573493,25147340,27057935,24098801,30718466,14557279,26697133,19898250,31022479,25623775,25151272,15505103,22155530,17184171,26908090,19515451,24906005,17434478,19261622,30081006,24464099,26520898,21875904,25512367,25682038,25518980,25159840,23602596,20299332,22305882,25247687,19251722,25315669,19590843,28232511,21562063,29908295,16616795,19458071,24048981,28634176,28253885,28117598,30767945,28758430,17516566,20389059,18091741,23204109,23006728,17097661,24021617,22155371,18493738,24695675,31825949,18825362,22744176,24075743,23607427,19666844,27496150,24716195,26774452,19668231,26903414,24734227,20685851,21933910,24349153,21817106,30372883,29077881,21982763,18437348,31759113,25904764,34943794,26800561,12221058,19181967,26908299,29269260,25012499,22549912,19362067,27133040,17611735,31511499,24657892,30017935,32066426,33430172,22572850,27898103,31533227,26891959,17272725,11390348,30753095,33925294,28754590,28687612,26477796,28971844,21782920,18635547,20861020,30296701,31614179,16357066,27264638,31590384,20354186,31382355,26926601,26924495,23267072,21121367,26276391,37006202,25768936,20159829,30096758,28329261,33719188,23499302,35179568,20307321,25764009,19584310,14644391,27618008,29359008,25623232,30165101,22192799,26014703,25815500,19675133,28585207,34452975,28209797,20943045,11978656,23812389,21747057,29263137,31068537,10744059,30063118,24296279,34637797,26898144,29545340,27897258,27465439,24886224,23472092,24612481,23193159,19060130,30223354,29288531,22580604,19858207,26386740,28137876,23018899,29094329,29339086,18606845,25742439,30293016,26798412,23259557,31174433,34379232,24114447,26150353,23421996,27412900,29059224,14690587,29371235,28406580,33231124,19485892,28359952,27157635,30213824,22302838,23448484,31614723,20238124,17311089,21640077,24184494,20392947,23648381,26569096,23329836,22467309,24941409,23851032,23776627,17993783,36012132,28890350,27889995,18707907,27859785,27102411,22037549,27907146,20351266,32359123,32026628,11205865,24093550,32353414,19307700,18809715,29507101,23171552,21778425,23994612,15923317,22772755,22238658,27598970,32019950,30930073,23524280,18758143,26254104,32347623,21326608,27554111,22279436,22011578,23300290,30072100,20592773,27105077,15010009,28036348,23454654,27128320,30359759,28506742,28546854,30640127,31133647,24744283,30217947,28830894,31462079,26876201,31302453,15793253,27833913,23019230,19210748,16317028,25114926,35643340,23046386,30905847,22158642,26781070,24989016,23030449,17416599,27852610,21071702,19149564,28286103,19485895,10963719,23564922,21360292,12797466,31838079,20637729,29543843,30367115,18504928,30253416,30397031,19395667,27834824,26543043,26914452,14527174,30025187,26494216,9335415,26941203,24489716,23606925,35345337,25896391,33515594,17360814,16327706,21810653,23641007,33258989,22776741,27101740,26622856,8742574,22210567,30878647,23077100,32045786,17178597,12160925,18591869,25451271,30018977,19875557,29024402,32969647,25789114,23771797,19383602,25563855,35782967,32116666,27273077,16075063,30077530,33358249,22204375,26985507,33644593,28132463,24498385,30144425,17337008,25109981,35415192,34724039,25184237,33080110,29967177,33360774,11824481,34719203,18407031,29924382,36235732,9823016,19219423,33177612,26271514,22474423,22661506,11245588,23195684,31389675,16598535,28819082,36766773,18752069,34682638,36394956,30846806,35091576,32650465,22632266,19756718,21270942,14505826,29923664,23975169,25838870,32630452,27043041,22129238,17434294,34707201,35742837,23449342,19488738,26718795,13679676,15265465,17375405,23374346,32584404,11400388,29849868,16101531,35461311,32122792,32675293,30705633,30271984,16627383,33070778,35571189,25143940,29862304,24646223,36051664,31198931,35631465,32376322,9272613,12592665,26435167,31722564,22101943,25317238,22821903,35955709,11440360,29304555,20739396,8654703,36357361,36980288,36463298,18221084,21164131,22013533,23917532,36895361,19273063,25705617,20046637,33995040,32377305,29255427,33371247,34658930,29643982,23573350,22617768,28203478,34573314,24429212,34439482,28932772,32944137,35285752,29066598,30294283,14567937,35757993,29325375,35095578[uid]

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478 results

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Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F. Paneni F, et al. Eur Heart J. 2015 Apr 1;36(13):817-28. doi: 10.1093/eurheartj/ehu179. Epub 2014 May 5. Eur Heart J. 2015. PMID: 24801072 Free article.

Pin1 inhibitor Juglone prevents diabetic vascular dysfunction.

Costantino S, Paneni F, Lüscher TF, Cosentino F. Costantino S, et al. Int J Cardiol. 2016 Jan 15;203:702-7. doi: 10.1016/j.ijcard.2015.10.221. Epub 2015 Oct 30. Int J Cardiol. 2016. PMID: 26583846

Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF, Cosentino F. Paneni F, et al. Circ Res. 2012 Jul 20;111(3):278-89. doi: 10.1161/CIRCRESAHA.112.266593. Epub 2012 Jun 12. Circ Res. 2012. PMID: 22693349

Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2.

Zhu M, Ding J, Jiang H, Kong L, Sun Z, Chen J, Miao C. Zhu M, et al. Vascul Pharmacol. 2015 Oct;73:149-57. doi: 10.1016/j.vph.2015.06.002. Epub 2015 Jun 10. Vascul Pharmacol. 2015. PMID: 26070526

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F. Camici GG, et al. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. doi: 10.1073/pnas.0609656104. Epub 2007 Mar 14. Proc Natl Acad Sci U S A. 2007. PMID: 17360381 Free PMC article.

Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IΚBα/NF-κB signaling pathway.

Jia Z, Nallasamy P, Liu D, Shah H, Li JZ, Chitrakar R, Si H, McCormick J, Zhu H, Zhen W, Li Y. Jia Z, et al. J Nutr Biochem. 2015 Mar;26(3):293-302. doi: 10.1016/j.jnutbio.2014.11.008. Epub 2014 Dec 15. J Nutr Biochem. 2015. PMID: 25577468 Free PMC article.

p66(Shc)-induced redox changes drive endothelial insulin resistance.

Paneni F, Costantino S, Cosentino F. Paneni F, et al. Atherosclerosis. 2014 Oct;236(2):426-9. doi: 10.1016/j.atherosclerosis.2014.07.027. Epub 2014 Aug 5. Atherosclerosis. 2014. PMID: 25150941

The Essential Role of Pin1 via NF-κB Signaling in Vascular Inflammation and Atherosclerosis in ApoE^-/- Mice.

Liu M, Yu P, Jiang H, Yang X, Zhao J, Zou Y, Ge J. Liu M, et al. Int J Mol Sci. 2017 Mar 16;18(3):644. doi: 10.3390/ijms18030644. Int J Mol Sci. 2017. PMID: 28300760 Free PMC article.

Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endothelial damage.

Spescha RD, Glanzmann M, Simic B, Witassek F, Keller S, Akhmedov A, Tanner FC, Lüscher TF, Camici GG. Spescha RD, et al. Hypertension. 2014 Aug;64(2):347-53. doi: 10.1161/HYPERTENSIONAHA.113.02129. Epub 2014 May 19. Hypertension. 2014. PMID: 24842918 Free article.

VDR Agonist Prevents Diabetic Endothelial Dysfunction through Inhibition of Prolyl Isomerase-1-Mediated Mitochondrial Oxidative Stress and Inflammation.

Zhang M, Lin L, Xu C, Chai D, Peng F, Lin J. Zhang M, et al. Oxid Med Cell Longev. 2018 Apr 15;2018:1714896. doi: 10.1155/2018/1714896. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29849865 Free PMC article.

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