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Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis.

Cartron PF, Petit E, Bellot G, Oliver L, Vallette FM.

Cell Signal. 2014 Sep;26(9):1928-34. doi: 10.1016/j.cellsig.2014.04.021. Epub 2014 May 2.


TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFalpha-induced apoptosis.

Ross K, Rudel T, Kozjak-Pavlovic V.

Cell Death Differ. 2009 May;16(5):697-707. doi: 10.1038/cdd.2008.194. Epub 2009 Jan 23.


Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.

Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G.

Cell Death Differ. 2014 Dec;21(12):1925-35. doi: 10.1038/cdd.2014.119. Epub 2014 Aug 22.


Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.

Plötz M, Gillissen B, Hossini AM, Daniel PT, Eberle J.

Cell Death Differ. 2012 Dec;19(12):1928-38. doi: 10.1038/cdd.2012.71. Epub 2012 Jun 15.


The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death.

Petit E, Cartron PF, Oliver L, Vallette FM.

Cell Signal. 2017 Jan;30:171-178. doi: 10.1016/j.cellsig.2016.11.008. Epub 2016 Nov 12.


Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K.

Sundararajan R, Cuconati A, Nelson D, White E.

J Biol Chem. 2001 Nov 30;276(48):45120-7. Epub 2001 Sep 24.


VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.

Roy SS, Ehrlich AM, Craigen WJ, Hajnóczky G.

EMBO Rep. 2009 Dec;10(12):1341-7. doi: 10.1038/embor.2009.219. Epub 2009 Oct 9.


VDAC2 inhibits BAK activation and mitochondrial apoptosis.

Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ.

Science. 2003 Jul 25;301(5632):513-7.


Differential retrotranslocation of mitochondrial Bax and Bak.

Todt F, Cakir Z, Reichenbach F, Emschermann F, Lauterwasser J, Kaiser A, Ichim G, Tait SW, Frank S, Langer HF, Edlich F.

EMBO J. 2015 Jan 2;34(1):67-80. doi: 10.15252/embj.201488806. Epub 2014 Nov 5.


Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death.

Wasiak S, Zunino R, McBride HM.

J Cell Biol. 2007 May 7;177(3):439-50. Epub 2007 Apr 30.


Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.

Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT.

J Biol Chem. 2010 Nov 19;285(47):36876-83. doi: 10.1074/jbc.M110.159301. Epub 2010 Sep 17.


Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak.

Kubli DA, Ycaza JE, Gustafsson AB.

Biochem J. 2007 Aug 1;405(3):407-15.


Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak.

Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, Kitanaka C.

J Natl Cancer Inst. 2006 Oct 18;98(20):1462-73.


Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.

Choi SY, Kim MJ, Kang CM, Bae S, Cho CK, Soh JW, Kim JH, Kang S, Chung HY, Lee YS, Lee SJ.

J Biol Chem. 2006 Mar 17;281(11):7049-59. Epub 2006 Jan 12.


Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

Naghdi S, Várnai P, Hajnóczky G.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5590-9. doi: 10.1073/pnas.1510574112. Epub 2015 Sep 28.


Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells.

Han J, Goldstein LA, Gastman BR, Rabinovitz A, Wang GQ, Fang B, Rabinowich H.

Leukemia. 2004 Oct;18(10):1671-80.


The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family.

Chipuk JE, Luna-Vargas MP.

J Cell Biol. 2017 Mar 6;216(3):547-549. doi: 10.1083/jcb.201701187. Epub 2017 Feb 13.


Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis.

Zhou L, Chang DC.

J Cell Sci. 2008 Jul 1;121(Pt 13):2186-96. doi: 10.1242/jcs.024703. Epub 2008 Jun 10.


Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

Parone PA, James DI, Da Cruz S, Mattenberger Y, Donzé O, Barja F, Martinou JC.

Mol Cell Biol. 2006 Oct;26(20):7397-408.

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