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Items: 1 to 20 of 98

1.

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.

O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM.

Biochem J. 2014 Aug 1;461(3):413-26. doi: 10.1042/BJ20140219.

PMID:
24785004
2.

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.

O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM.

J Neurosci. 2010 Oct 27;30(43):14411-9. doi: 10.1523/JNEUROSCI.3537-10.2010.

3.

Specific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process.

Wahlström A, Cukalevski R, Danielsson J, Jarvet J, Onagi H, Rebek J Jr, Linse S, Gräslund A.

Biochemistry. 2012 May 29;51(21):4280-9. doi: 10.1021/bi300341j. Epub 2012 May 17.

PMID:
22554145
4.

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM.

J Neurochem. 2011 Oct;119(1):189-201. doi: 10.1111/j.1471-4159.2011.07389.x. Epub 2011 Aug 22.

5.

Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.

Chen YR, Huang HB, Lo CJ, Wang CC, Su CL, Liu HT, Shiao MS, Lin TH, Chen YC.

Biochem Biophys Res Commun. 2011 Feb 4;405(1):91-5. doi: 10.1016/j.bbrc.2010.12.133. Epub 2011 Jan 7.

PMID:
21216230
6.

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

Zago W, Buttini M, Comery TA, Nishioka C, Gardai SJ, Seubert P, Games D, Bard F, Schenk D, Kinney GG.

J Neurosci. 2012 Feb 22;32(8):2696-702. doi: 10.1523/JNEUROSCI.1676-11.2012.

7.

Conformations and biological activities of amyloid beta peptide 25-35.

Millucci L, Ghezzi L, Bernardini G, Santucci A.

Curr Protein Pept Sci. 2010 Feb;11(1):54-67. Review.

PMID:
20201807
8.

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ.

Nat Med. 2008 Aug;14(8):837-42. doi: 10.1038/nm1782. Epub 2008 Jun 22.

9.

Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.

Harmeier A, Wozny C, Rost BR, Munter LM, Hua H, Georgiev O, Beyermann M, Hildebrand PW, Weise C, Schaffner W, Schmitz D, Multhaup G.

J Neurosci. 2009 Jun 10;29(23):7582-90. doi: 10.1523/JNEUROSCI.1336-09.2009.

10.

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer.

O'Malley TT, Witbold WM 3rd, Linse S, Walsh DM.

Biochemistry. 2016 Nov 8;55(44):6150-6161. Epub 2016 Oct 26.

PMID:
27750419
11.
12.

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H.

J Neurochem. 2005 Nov;95(3):834-47. Epub 2005 Aug 31.

13.

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N.

Tatini F, Pugliese AM, Traini C, Niccoli S, Maraula G, Ed Dami T, Mannini B, Scartabelli T, Pedata F, Casamenti F, Chiti F.

Neurobiol Aging. 2013 Sep;34(9):2100-9. doi: 10.1016/j.neurobiolaging.2013.03.020. Epub 2013 Apr 18.

PMID:
23601807
14.
15.

Aβ-40 Y10F increases βfibrils formation but attenuates the neurotoxicity of amyloid-β peptide.

Dai X, Chang P, Liu W, Xu K, Sun Y, Zhu S, Jiang Z.

Int J Mol Sci. 2012;13(5):5324-37. doi: 10.3390/ijms13055324. Epub 2012 Apr 25.

16.

DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.

Dahse K, Garvey M, Kovermann M, Vogel A, Balbach J, Fändrich M, Fahr A.

J Mol Biol. 2010 Nov 5;403(4):643-59. doi: 10.1016/j.jmb.2010.09.021. Epub 2010 Sep 17.

PMID:
20851128
17.

Low-n oligomers as therapeutic targets of Alzheimer's disease.

Ono K, Yamada M.

J Neurochem. 2011 Apr;117(1):19-28. doi: 10.1111/j.1471-4159.2011.07187.x. Epub 2011 Feb 9. Review.

18.

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC.

Biochemistry. 2011 Sep 27;50(38):8127-37. doi: 10.1021/bi201246t. Epub 2011 Sep 1.

PMID:
21838267
19.

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu S, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima Y, Kakita A, Imahori K, Hoshi M.

J Biol Chem. 2009 Nov 20;284(47):32895-905. doi: 10.1074/jbc.M109.000208. Epub 2009 Sep 15.

20.

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice.

Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F.

EMBO J. 2008 Jan 9;27(1):224-33. Epub 2007 Dec 6.

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