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The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment.

Yang W, Lee YH, Jones AE, Woolnough JL, Zhou D, Dai Q, Wu Q, Giles KE, Townes TM, Wang H.

Nat Commun. 2014 May 2;5:3818. doi: 10.1038/ncomms4818.


The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.

Gu Y, Jones AE, Yang W, Liu S, Dai Q, Liu Y, Swindle CS, Zhou D, Zhang Z, Ryan TM, Townes TM, Klug CA, Chen D, Wang H.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E51-60. doi: 10.1073/pnas.1517041113. Epub 2015 Dec 22.


The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.

Zhang Z, Yang H, Wang H.

J Biol Chem. 2014 Nov 21;289(47):32883-94. doi: 10.1074/jbc.M114.599605. Epub 2014 Oct 10.


H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation.

Subramanian V, Mazumder A, Surface LE, Butty VL, Fields PA, Alwan A, Torrey L, Thai KK, Levine SS, Bathe M, Boyer LA.

PLoS Genet. 2013;9(8):e1003725. doi: 10.1371/journal.pgen.1003725. Epub 2013 Aug 22.


Regulation of cell cycle progression and gene expression by H2A deubiquitination.

Joo HY, Zhai L, Yang C, Nie S, Erdjument-Bromage H, Tempst P, Chang C, Wang H.

Nature. 2007 Oct 25;449(7165):1068-72. Epub 2007 Oct 3.


Polycomb Repressive Complex 2 regulates lineage fidelity during embryonic stem cell differentiation.

Thornton SR, Butty VL, Levine SS, Boyer LA.

PLoS One. 2014 Oct 21;9(10):e110498. doi: 10.1371/journal.pone.0110498. eCollection 2014.


The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).

Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB.

J Biol Chem. 2013 Aug 16;288(33):24234-46. doi: 10.1074/jbc.M113.469783. Epub 2013 Jun 12.


Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation.

Obier N, Lin Q, Cauchy P, Hornich V, Zenke M, Becker M, Müller AM.

Stem Cell Rev. 2015 Feb;11(1):50-61. doi: 10.1007/s12015-014-9550-z.


Usp16 contributes to somatic stem-cell defects in Down's syndrome.

Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF.

Nature. 2013 Sep 19;501(7467):380-4. doi: 10.1038/nature12530. Epub 2013 Sep 11.


Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.

Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J.

Nature. 2010 May 13;465(7295):243-7. doi: 10.1038/nature08966. Epub 2010 May 2.


H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.

Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K.

Cell Stem Cell. 2013 Feb 7;12(2):180-92. doi: 10.1016/j.stem.2012.11.003. Epub 2012 Dec 20.


Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R.

PLoS Genet. 2013 May;9(5):e1003424. doi: 10.1371/journal.pgen.1003424. Epub 2013 May 2.


Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs.

Wu T, Liu Y, Wen D, Tseng Z, Tahmasian M, Zhong M, Rafii S, Stadtfeld M, Hochedlinger K, Xiao A.

Cell Stem Cell. 2014 Sep 4;15(3):281-94. doi: 10.1016/j.stem.2014.06.004.


Histone variants as emerging regulators of embryonic stem cell identity.

Turinetto V, Giachino C.

Epigenetics. 2015;10(7):563-73. doi: 10.1080/15592294.2015.1053682. Review.


Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.

Nakagawa T, Kajitani T, Togo S, Masuko N, Ohdan H, Hishikawa Y, Koji T, Matsuyama T, Ikura T, Muramatsu M, Ito T.

Genes Dev. 2008 Jan 1;22(1):37-49. doi: 10.1101/gad.1609708.


PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

Illingworth RS, Botting CH, Grimes GR, Bickmore WA, Eskeland R.

PLoS One. 2012;7(4):e34848. doi: 10.1371/journal.pone.0034848. Epub 2012 Apr 9.


Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.

Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Müller AM.

Stem Cells. 2014 Dec;32(12):3112-25. doi: 10.1002/stem.1826.


Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.

Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H.

PLoS Genet. 2012;8(7):e1002774. doi: 10.1371/journal.pgen.1002774. Epub 2012 Jul 26.


Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.

Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H.

J Biol Chem. 2011 Mar 4;286(9):7190-201. doi: 10.1074/jbc.M110.158311. Epub 2010 Dec 23.


Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation.

Fang J, Chen T, Chadwick B, Li E, Zhang Y.

J Biol Chem. 2004 Dec 17;279(51):52812-5. Epub 2004 Oct 26.

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