Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 81

1.

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chembiochem. 2014 May 26;15(8):1083-7. doi: 10.1002/cbic.201400009. Epub 2014 Apr 29.

2.

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chem Commun (Camb). 2016 Apr 7;52(31):5421-4. doi: 10.1039/c6cc01812b.

3.

Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300.

Na YR, Han KC, Park H, Yang EG.

Biochem Biophys Res Commun. 2013 May 17;434(4):879-84. doi: 10.1016/j.bbrc.2013.04.044. Epub 2013 Apr 22.

PMID:
23618863
4.

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.

PMID:
25892103
5.
6.

Visualization of hypoxia-inducible factor 1α-p300 interactions in live cells by fluorescence resonance energy transfer.

Kim SY, Lee MJ, Na YR, Kim SY, Yang EG.

J Cell Biochem. 2014 Feb;115(2):271-80. doi: 10.1002/jcb.24659.

PMID:
23966271
7.

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, Pereira T, Poellinger L.

J Biol Chem. 2010 Jan 22;285(4):2601-9. doi: 10.1074/jbc.M109.021824. Epub 2009 Oct 30.

8.

Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.

Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, Ahn DR.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5249-52. doi: 10.1016/j.bmcl.2012.06.054. Epub 2012 Jun 23.

PMID:
22789427
9.

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction.

Cardoso R, Love R, Nilsson CL, Bergqvist S, Nowlin D, Yan J, Liu KK, Zhu J, Chen P, Deng YL, Dyson HJ, Greig MJ, Brooun A.

Protein Sci. 2012 Dec;21(12):1885-96. doi: 10.1002/pro.2172. Epub 2012 Nov 9.

10.

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA.

Mol Biosyst. 2015 Oct;11(10):2738-49. doi: 10.1039/c5mb00284b.

PMID:
26135796
11.

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD.

Eur J Med Chem. 2015 Apr 13;94:509-16. doi: 10.1016/j.ejmech.2014.06.006. Epub 2014 Jun 27.

12.

Multivalent helix mimetics for PPI-inhibition.

Barnard A, Miles JA, Burslem GM, Barker AM, Wilson AJ.

Org Biomol Chem. 2015 Jan 7;13(1):258-64. doi: 10.1039/c4ob02066a.

PMID:
25408290
13.

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.

Lao BB, Grishagin I, Mesallati H, Brewer TF, Olenyuk BZ, Arora PS.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. doi: 10.1073/pnas.1402393111. Epub 2014 May 12.

14.

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.

Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ.

Nat Struct Biol. 2003 Jul;10(7):504-12.

PMID:
12778114
15.

A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain.

Wu D, Zhang R, Zhao R, Chen G, Cai Y, Jin J.

PLoS One. 2013 May 6;8(5):e62014. doi: 10.1371/journal.pone.0062014. Print 2013.

16.

Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

Park EJ, Kong D, Fisher R, Cardellina J, Shoemaker RH, Melillo G.

Cell Cycle. 2006 Aug;5(16):1847-53. Epub 2006 Aug 15.

PMID:
16861921
17.

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ.

J Biol Chem. 2009 Sep 25;284(39):26831-8. doi: 10.1074/jbc.M109.009498. Epub 2009 Jul 9.

18.

NF-κB suppresses HIF-1α response by competing for P300 binding.

Mendonça DB, Mendonça G, Aragão FJ, Cooper LF.

Biochem Biophys Res Commun. 2011 Jan 28;404(4):997-1003. doi: 10.1016/j.bbrc.2010.12.098. Epub 2010 Dec 25.

PMID:
21187066
19.

Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells.

Yoshida T, Hashimura M, Mastumoto T, Tazo Y, Inoue H, Kuwata T, Saegusa M.

Lab Invest. 2013 Nov;93(11):1184-93. doi: 10.1038/labinvest.2013.111. Epub 2013 Sep 16.

20.

Prolonged fasting activates hypoxia inducible factors-1α, -2α and -3α in a tissue-specific manner in northern elephant seal pups.

Soñanez-Organis JG, Vázquez-Medina JP, Crocker DE, Ortiz RM.

Gene. 2013 Sep 10;526(2):155-63. doi: 10.1016/j.gene.2013.05.004. Epub 2013 May 22.

Supplemental Content

Support Center