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Items: 1 to 20 of 112

1.

Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.

Annys E, Billington R, Clayton R, Bremm KD, Graziano M, McKelvie J, Ragan I, Schwarz M, van der Laan JW, Wood C, Öberg M, Wester P, Woodward KN.

Regul Toxicol Pharmacol. 2014 Jul;69(2):234-42. doi: 10.1016/j.yrtph.2014.04.009.

PMID:
24768934
2.

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.

Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco M, Guinea J, Klüver N, Schirmer K, Tanneberger K, Tobor-Kapłon M, Witters H, Belanger S, Benfenati E, Creton S, Cronin MT, Eggen RI, Embry M, Ekman D, Gourmelon A, Halder M, Hardy B, Hartung T, Hubesch B, Jungmann D, Lampi MA, Lee L, Léonard M, Küster E, Lillicrap A, Luckenbach T, Murk AJ, Navas JM, Peijnenburg W, Repetto G, Salinas E, Schüürmann G, Spielmann H, Tollefsen KE, Walter-Rohde S, Whale G, Wheeler JR, Winter MJ.

Regul Toxicol Pharmacol. 2013 Dec;67(3):506-30. doi: 10.1016/j.yrtph.2013.10.003. Review.

PMID:
24161465
4.

Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals.

Beken S, Kasper P, van der Laan JW.

Adv Exp Med Biol. 2016;856:33-64.

PMID:
27671719
5.

Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals.

Brambilla G, Martelli A.

Mutat Res. 2009 Mar-Jun;681(2-3):209-29. doi: 10.1016/j.mrrev.2008.09.002.

PMID:
18845271
6.

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

Schroeder K, Bremm KD, Alépée N, Bessems JG, Blaauboer B, Boehn SN, Burek C, Coecke S, Gombau L, Hewitt NJ, Heylings J, Huwyler J, Jaeger M, Jagelavicius M, Jarrett N, Ketelslegers H, Kocina I, Koester J, Kreysa J, Note R, Poth A, Radtke M, Rogiers V, Scheel J, Schulz T, Steinkellner H, Toeroek M, Whelan M, Winkler P, Diembeck W.

Toxicol In Vitro. 2011 Apr;25(3):589-604. doi: 10.1016/j.tiv.2010.12.005. Review.

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9.

The transgenic mouse assay as an alternative test method for regulatory carcinogenicity studies--implications for REACH.

Wells MY, Williams ES.

Regul Toxicol Pharmacol. 2009 Mar;53(2):150-5. doi: 10.1016/j.yrtph.2008.12.006.

PMID:
19126422
11.

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH).

Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Kramer PJ, Schweinfurth H, Wollin KM.

Arch Toxicol. 2008 Apr;82(4):211-36. doi: 10.1007/s00204-008-0279-9.

PMID:
18322675
13.

The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides.

Billington R, Lewis RW, Mehta JM, Dewhurst I.

Crit Rev Toxicol. 2010 Jan;40(1):35-49. doi: 10.3109/10408440903367741. Review.

PMID:
20144135
14.

A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients.

Hayes AW, Dayan AD, Hall WC, Kodell RL, Williams GM, Waddell WD, Slesinski RS, Kruger CL.

Regul Toxicol Pharmacol. 2011 Jun;60(1 Suppl):S1-34. doi: 10.1016/j.yrtph.2010.10.002.

PMID:
21094668
15.

Scientific analysis of the proposed uses of the T25 dose descriptor in chemical carcinogen regulation.

Roberts RA, Crump KS, Lutz WK, Wiegand HJ, Williams GM, Harrison PT, Purchase IF.

Arch Toxicol. 2001 Nov;75(9):507-12.

PMID:
11760810
16.

Evaluation of carcinogenicity studies of medicinal products for human use authorised via the European centralised procedure (1995-2009).

Friedrich A, Olejniczak K.

Regul Toxicol Pharmacol. 2011 Jul;60(2):225-48. doi: 10.1016/j.yrtph.2011.04.001.

PMID:
21513764
18.

Risk assessment of nanomaterials in cosmetics: a European union perspective.

Henkler F, Tralau T, Tentschert J, Kneuer C, Haase A, Platzek T, Luch A, Götz ME.

Arch Toxicol. 2012 Nov;86(11):1641-6. doi: 10.1007/s00204-012-0944-x.

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Evaluation of reduced protocols for carcinogenicity testing of chemicals: report of a joint EPA/NIEHS workshop.

Lai DY, Baetcke KP, Vu VT, Cotruvo JA, Eustis SL.

Regul Toxicol Pharmacol. 1994 Apr;19(2):183-201. Review.

PMID:
8041916
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