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Items: 1 to 20 of 102

1.

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells.

Aziz MY, Omar AR, Subramani T, Yeap SK, Ho WY, Ismail NH, Ahmad S, Alitheen NB.

Oncol Lett. 2014 May;7(5):1479-1484. Epub 2014 Feb 20.

2.

Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells.

Nualsanit T, Rojanapanthu P, Gritsanapan W, Lee SH, Lawson D, Baek SJ.

J Nutr Biochem. 2012 Aug;23(8):915-23. doi: 10.1016/j.jnutbio.2011.04.017. Epub 2011 Aug 17.

3.

Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways.

Lin FL, Hsu JL, Chou CH, Wu WJ, Chang CI, Liu HJ.

Eur J Pharmacol. 2011 Jan 10;650(1):120-9. doi: 10.1016/j.ejphar.2010.10.005. Epub 2010 Oct 14.

PMID:
20951126
4.

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line.

Yeap S, Akhtar MN, Lim KL, Abu N, Ho WY, Zareen S, Roohani K, Ky H, Tan SW, Lajis N, Alitheen NB.

Drug Des Devel Ther. 2015 Feb 17;9:983-92. doi: 10.2147/DDDT.S65468. eCollection 2015 Feb 17.

5.

Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro.

Aziz MY, Abu N, Yeap SK, Ho WY, Omar AR, Ismail NH, Ahmad S, Pirozyan MR, Akhtar NM, Alitheen NB.

Molecules. 2016 Sep 14;21(9). pii: E1228. doi: 10.3390/molecules21091228.

6.

Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway.

Foo JB, Saiful Yazan L, Tor YS, Wibowo A, Ismail N, How CW, Armania N, Loh SP, Ismail IS, Cheah YK, Abdullah R.

J Ethnopharmacol. 2015 May 26;166:270-8. doi: 10.1016/j.jep.2015.03.039. Epub 2015 Mar 19.

PMID:
25797115
7.

Damnacanthal and its nanoformulation exhibit anti-cancer activity via cyclin D1 down-regulation.

Sukamporn P, Rojanapanthu P, Silva G, Zhang X, Gritsanapan W, Baek SJ.

Life Sci. 2016 May 1;152:60-6. doi: 10.1016/j.lfs.2016.03.038. Epub 2016 Mar 24.

PMID:
27018445
8.

Cell cycle arrest and mechanism of apoptosis induction in H400 oral cancer cells in response to Damnacanthal and Nordamnacanthal isolated from Morinda citrifolia.

Shaghayegh G, Alabsi AM, Ali-Saeed R, Ali AM, Vincent-Chong VK, Zain RB.

Cytotechnology. 2016 Oct;68(5):1999-2013. doi: 10.1007/s10616-016-0014-y. Epub 2016 Aug 3.

PMID:
27488882
9.

The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects.

García-Vilas JA, Pino-Ángeles A, Martínez-Poveda B, Quesada AR, Medina MÁ.

Cancer Lett. 2017 Jan 28;385:1-11. doi: 10.1016/j.canlet.2016.10.037. Epub 2016 Nov 2.

PMID:
27816491
10.

Damnacanthal inhibits the NF-κB/RIP-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase.

Kim MH, Jeong HJ.

Immunopharmacol Immunotoxicol. 2014 Oct;36(5):355-63. doi: 10.3109/08923973.2014.952819. Epub 2014 Aug 20.

PMID:
25139491
11.

Damnacanthal: a promising compound as a medicinal anthraquinone.

Abu N, Ali NM, Ho WY, Yeap SK, Aziz MY, Alitheen NB.

Anticancer Agents Med Chem. 2014 Jun;14(5):750-5. Review.

PMID:
24164045
12.
13.

Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines.

Sharma K, Pachauri SD, Khandelwal K, Ahmad H, Arya A, Biala P, Agrawal S, Pandey RR, Srivastava A, Srivastav A, Saxena JK, Dwivedi AK.

Drug Res (Stuttg). 2016 Mar;66(3):141-7. doi: 10.1055/s-0035-1555804. Epub 2015 Jul 9.

PMID:
26158795
14.

An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.

Lam M, Carmichael AR, Griffiths HR.

PLoS One. 2012;7(6):e40152. doi: 10.1371/journal.pone.0040152. Epub 2012 Jun 27. Erratum in: PLoS One. 2014 Jul;9(7):e102655.

15.
16.

Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27.

Karimian H, Moghadamtousi SZ, Fadaeinasab M, Golbabapour S, Razavi M, Hajrezaie M, Arya A, Abdulla MA, Mohan S, Ali HM, Noordin MI.

Drug Des Devel Ther. 2014 Sep 22;8:1481-97. doi: 10.2147/DDDT.S68818. eCollection 2014 Sep 22.

17.

Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile.

Tor YS, Yazan LS, Foo JB, Wibowo A, Ismail N, Cheah YK, Abdullah R, Ismail M, Ismail IS, Yeap SK.

PLoS One. 2015 Jun 5;10(6):e0127441. doi: 10.1371/journal.pone.0127441. eCollection 2015 Jun 5.

18.

IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.

Zuo S, Liu C, Wang J, Wang F, Xu W, Cui S, Yuan L, Chen X, Fan W, Cui M, Song G.

J Cancer Res Clin Oncol. 2012 Jun;138(6):1045-55. doi: 10.1007/s00432-012-1153-y. Epub 2012 Mar 6.

PMID:
22392074
19.

Damnacanthal inhibits IgE receptor-mediated activation of mast cells.

Garcia-Vilas JA, Medina MA, Melo FR, Pejler G, Garcia-Faroldi G.

Mol Immunol. 2015 May;65(1):86-93. doi: 10.1016/j.molimm.2015.01.008. Epub 2015 Feb 2.

PMID:
25656801
20.

Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2.

Ou X, Lu Y, Liao L, Li D, Liu L, Liu H, Xu H.

Oncol Rep. 2015 Mar;33(3):1264-74. doi: 10.3892/or.2014.3688. Epub 2014 Dec 22.

PMID:
25530218

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