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Items: 1 to 20 of 95


Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.

Bhadra R, Moretto MM, Castillo JC, Petrovas C, Ferrando-Martinez S, Shokal U, Leal M, Koup RA, Eleftherianos I, Khan IA.

J Clin Invest. 2014 Jun;124(6):2441-55. doi: 10.1172/JCI70522. Epub 2014 Apr 24.


Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.

Gigley JP, Khan IA.

PLoS One. 2011;6(6):e20838. doi: 10.1371/journal.pone.0020838. Epub 2011 Jun 10.


The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.

Li C, Jiao S, Wang G, Gao Y, Liu C, He X, Zhang C, Xiao J, Li W, Zhang G, Wei B, Chen H, Wang H.

PLoS Pathog. 2015 Apr 24;11(4):e1004824. doi: 10.1371/journal.ppat.1004824. eCollection 2015 Apr.


Inhibition of TGF-β1 signaling promotes central memory T cell differentiation.

Takai S, Schlom J, Tucker J, Tsang KY, Greiner JW.

J Immunol. 2013 Sep 1;191(5):2299-307. doi: 10.4049/jimmunol.1300472. Epub 2013 Jul 31.


IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.

Moretto MM, Khan IA.

J Immunol. 2016 Jan 1;196(1):375-84. doi: 10.4049/jimmunol.1501258. Epub 2015 Nov 23.


Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.

Sanjabi S, Mosaheb MM, Flavell RA.

Immunity. 2009 Jul 17;31(1):131-44. doi: 10.1016/j.immuni.2009.04.020.


CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-β (TGF-β)-mediated suppression.

Zloza A, Jagoda MC, Lyons GE, Graves MC, Kohlhapp FJ, O'Sullivan JA, Lacek AT, Nishimura MI, Guevara-Patiño JA.

Cancer Immunol Immunother. 2011 Feb;60(2):291-7. doi: 10.1007/s00262-010-0962-6. Epub 2010 Dec 31.


Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.

Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG.

Diabetes. 2008 Oct;57(10):2684-92. doi: 10.2337/db08-0609. Epub 2008 Aug 8.


Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes.

Papadakis KA, Krempski J, Reiter J, Svingen P, Xiong Y, Sarmento OF, Huseby A, Johnson AJ, Lomberk GA, Urrutia RA, Faubion WA.

Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C362-71. doi: 10.1152/ajpcell.00262.2014. Epub 2014 Dec 3.


Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice.

Smithey MJ, Renkema KR, Rudd BD, Nikolich-Žugich J.

Eur J Immunol. 2011 May;41(5):1352-64. doi: 10.1002/eji.201041141. Epub 2011 Apr 14.


Tumor-derived chemokine CCL5 enhances TGF-β-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells.

Chang LY, Lin YC, Mahalingam J, Huang CT, Chen TW, Kang CW, Peng HM, Chu YY, Chiang JM, Dutta A, Day YJ, Chen TC, Yeh CT, Lin CY.

Cancer Res. 2012 Mar 1;72(5):1092-102. doi: 10.1158/0008-5472.CAN-11-2493. Epub 2012 Jan 26.


Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells.

Zhang Q, Jang TL, Yang X, Park I, Meyer RE, Kundu S, Pins M, Javonovic B, Kuzel T, Kim SJ, Van Parijs L, Smith N, Wong L, Greenberg NM, Guo Y, Lee C.

Prostate. 2006 Feb 15;66(3):235-47.


Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo.

Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI.

Immunity. 2009 Jul 17;31(1):145-57. doi: 10.1016/j.immuni.2009.06.015.


Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells.

Bhadra R, Gigley JP, Khan IA.

J Immunol. 2011 Nov 1;187(9):4421-5. doi: 10.4049/jimmunol.1102319. Epub 2011 Sep 26.


Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infection.

Moretto MM, Lawlor EM, Khan IA.

Infect Immun. 2010 Jun;78(6):2505-11. doi: 10.1128/IAI.00753-09. Epub 2010 Mar 22.


TGF-beta superfamily enhances the antigen-induced IFN-gamma production by effector/memory CD8+ T cells.

Takai S, Tokuda H, Matsushima-Nishiwaki R, Saio M, Takami T, Kozawa O.

Int J Mol Med. 2010 Jan;25(1):105-11.


Soluble type II transforming growth factor-beta receptor inhibits established murine malignant mesothelioma tumor growth by augmenting host antitumor immunity.

Suzuki E, Kapoor V, Cheung HK, Ling LE, DeLong PA, Kaiser LR, Albelda SM.

Clin Cancer Res. 2004 Sep 1;10(17):5907-18.

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