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Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer.

Zick SM, Turgeon DK, Ren J, Ruffin MT, Wright BD, Sen A, Djuric Z, Brenner DE.

Mol Carcinog. 2015 Sep;54(9):908-15. doi: 10.1002/mc.22163. Epub 2014 Apr 24.


Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer.

Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright BD, Alrawi S, Normolle DP, Djuric Z, Brenner DE.

Cancer Prev Res (Phila). 2011 Nov;4(11):1929-37. doi: 10.1158/1940-6207.CAPR-11-0224. Epub 2011 Oct 11.


Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer.

Jiang Y, Turgeon DK, Wright BD, Sidahmed E, Ruffin MT, Brenner DE, Sen A, Zick SM.

Eur J Cancer Prev. 2013 Sep;22(5):455-60. doi: 10.1097/CEJ.0b013e32835c829b.


Effect of aspirin on prostaglandin E2 and leukotriene B4 production in human colonic mucosa from cancer patients.

Frommel TO, Dyavanapalli M, Oldham T, Kazi N, Lietz H, Liao Y, Mobarhan S.

Clin Cancer Res. 1997 Feb;3(2):209-13.


Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial.

Citronberg J, Bostick R, Ahearn T, Turgeon DK, Ruffin MT, Djuric Z, Sen A, Brenner DE, Zick SM.

Cancer Prev Res (Phila). 2013 Apr;6(4):271-81. doi: 10.1158/1940-6207.CAPR-12-0327. Epub 2013 Jan 9.


Effects of piroxicam on prostaglandin E2 levels in rectal mucosa of adenomatous polyp patients: a randomized phase IIb trial.

Calaluce R, Earnest DL, Heddens D, Einspahr JG, Roe D, Bogert CL, Marshall JR, Alberts DS.

Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1287-92.


Ginger: is it ready for prime time?

Stoner GD.

Cancer Prev Res (Phila). 2013 Apr;6(4):257-62. doi: 10.1158/1940-6207.CAPR-13-0055.


Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.

Thompson PA, Wertheim BC, Zell JA, Chen WP, McLaren CE, LaFleur BJ, Meyskens FL, Gerner EW.

Gastroenterology. 2010 Sep;139(3):797-805, 805.e1. doi: 10.1053/j.gastro.2010.06.005. Epub 2010 Jun 9.


Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention.

Cathcart MC, Lysaght J, Pidgeon GP.

Cancer Metastasis Rev. 2011 Dec;30(3-4):363-85. doi: 10.1007/s10555-011-9324-x. Review.


Altered eicosanoid levels in human colon cancer.

Rigas B, Goldman IS, Levine L.

J Lab Clin Med. 1993 Nov;122(5):518-23.


15-HETE is the main eicosanoid formed by human colonic mucosa.

Zijlstra FJ, van Dijk AP, Wilson JH, van Riemsdijk-Overbeeke IC, Vincent JE, Ouwendijk RJ.

Agents Actions. 1992;Spec No:C53-9.


Effects of calcium and vitamin D3 on transforming growth factors in rectal mucosa of sporadic colorectal adenoma patients: a randomized controlled trial.

Tu H, Flanders WD, Ahearn TU, Daniel CR, Gonzalez-Feliciano AG, Long Q, Rutherford RE, Bostick RM.

Mol Carcinog. 2015 Apr;54(4):270-80. doi: 10.1002/mc.22096. Epub 2013 Oct 26.


Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer.

Mal M, Koh PK, Cheah PY, Chan EC.

Rapid Commun Mass Spectrom. 2011 Mar 30;25(6):755-64. doi: 10.1002/rcm.4926.


Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose.

Ruffin MT 4th, Krishnan K, Rock CL, Normolle D, Vaerten MA, Peters-Golden M, Crowell J, Kelloff G, Boland CR, Brenner DE.

J Natl Cancer Inst. 1997 Aug 6;89(15):1152-60.


Chemoprevention of colorectal cancer: systematic review and economic evaluation.

Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D, Tappenden P.

Health Technol Assess. 2010 Jun;14(32):1-206. doi: 10.3310/hta14320. Review.


Lack of chemopreventive effects of ginger on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.

Dias MC, Spinardi-Barbisan AL, Rodrigues MA, de Camargo JL, Terán E, Barbisan LF.

Food Chem Toxicol. 2006 Jun;44(6):877-84. Epub 2006 Jan 27.


Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-κB p65ser(311) signaling via IκB-α and GSK-3β reduced phosphorylation.

Puangpraphant S, Dia VP, de Mejia EG, Garcia G, Berhow MA, Wallig MA.

Biofactors. 2013 Jul-Aug;39(4):430-40. doi: 10.1002/biof.1083. Epub 2013 Mar 29.


Effect of drugs on colonic eicosanoid accumulation in active ulcerative colitis.

Eliakim R, Karmeli F, Chorev M, Okon E, Rachmilewitz D.

Scand J Gastroenterol. 1992 Nov;27(11):968-72.


Does ursodeoxycholic acid change the proliferation of the colorectal mucosa?. A randomized, placebo-controlled study.

Ochsenkühn T, Marsteller I, Hay U, Diebold J, Paumgartner G, Göke B, Sackmann M.

Digestion. 2003;68(4):209-16. Epub 2003 Dec 30.


Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.

O'Dwyer PJ, Szarka CE, Yao KS, Halbherr TC, Pfeiffer GR, Green F, Gallo JM, Brennan J, Frucht H, Goosenberg EB, Hamilton TC, Litwin S, Balshem AM, Engstrom PF, Clapper ML.

J Clin Invest. 1996 Sep 1;98(5):1210-7.

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