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Items: 1 to 20 of 30

1.

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.

Choudhary A, Hu He K, Mertins P, Udeshi ND, Dančík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK.

PLoS One. 2014 Apr 23;9(4):e95194. doi: 10.1371/journal.pone.0095194. eCollection 2014.

2.

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104. doi: 10.1073/pnas.1010018107. Epub 2010 Aug 9.

3.

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

Fomina-Yadlin D, Kubicek S, Vetere A, He KH, Schreiber SL, Wagner BK.

PLoS One. 2012;7(1):e28808. doi: 10.1371/journal.pone.0028808. Epub 2012 Jan 5. Erratum in: PLoS One. 2012;7(3). doi: 10.1371/annotation/c41ac082-32ac-4837-b4ed-9fd8ad91c1e0. He, Kaihui Hu [corrected to He, Kai Hui Hu].

4.

Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.

5.

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH.

J Clin Invest. 2013 Mar;123(3):1275-84. doi: 10.1172/JCI66514. Epub 2013 Feb 22.

6.

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX.

Gastroenterology. 2010 May;138(5):1954-65. doi: 10.1053/j.gastro.2010.01.046. Epub 2010 Feb 2.

PMID:
20138042
7.

Comprehensive phosphoproteome analysis of INS-1 pancreatic β-cells using various digestion strategies coupled with liquid chromatography-tandem mass spectrometry.

Han D, Moon S, Kim Y, Ho WK, Kim K, Kang Y, Jun H, Kim Y.

J Proteome Res. 2012 Apr 6;11(4):2206-23. doi: 10.1021/pr200990b. Epub 2012 Mar 14.

PMID:
22276854
8.

A new paradigm in cell therapy for diabetes: turning pancreatic α-cells into β-cells.

Sangan CB, Tosh D.

Bioessays. 2010 Oct;32(10):881-4. doi: 10.1002/bies.201000074. Epub 2010 Aug 27.

PMID:
20803505
9.

Pancreatic β-cell neogenesis by direct conversion from mature α-cells.

Chung CH, Hao E, Piran R, Keinan E, Levine F.

Stem Cells. 2010 Sep;28(9):1630-8. doi: 10.1002/stem.482.

10.

Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets.

Takahashi R, Ishihara H, Tamura A, Yamaguchi S, Yamada T, Takei D, Katagiri H, Endou H, Oka Y.

Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E308-16. Epub 2005 Sep 27.

11.

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.

Ackermann AM, Moss NG, Kaestner KH.

Cell Metab. 2018 Nov 6;28(5):787-792.e3. doi: 10.1016/j.cmet.2018.07.002. Epub 2018 Jul 26.

PMID:
30057067
12.

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P.

Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27.

13.

Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice.

Kornete M, Beauchemin H, Polychronakos C, Piccirillo CA.

Autoimmunity. 2013 Jun;46(4):259-68. doi: 10.3109/08916934.2012.752462. Epub 2013 Feb 4.

PMID:
23256897
14.

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

Sangan CB, Jover R, Heimberg H, Tosh D.

Mol Cell Endocrinol. 2015 Jan 5;399:50-9. doi: 10.1016/j.mce.2014.09.009. Epub 2014 Sep 16.

PMID:
25224487
15.

Epigenetic-mediated reprogramming of pancreatic endocrine cells.

Mathiyalagan P, Keating ST, Al-Hasani K, El-Osta A.

Antioxid Redox Signal. 2015 Jun 1;22(16):1483-95. doi: 10.1089/ars.2014.6103. Epub 2015 Mar 18. Review.

PMID:
25621632
16.

Conversion of mature human β-cells into glucagon-producing α-cells.

Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ.

Diabetes. 2013 Jul;62(7):2471-80. doi: 10.2337/db12-1001. Epub 2013 Apr 8.

17.

Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets.

Tian G, Sandler S, Gylfe E, Tengholm A.

Diabetes. 2011 May;60(5):1535-43. doi: 10.2337/db10-1087. Epub 2011 Mar 28.

18.

Growth factor signalling in the regulation of α-cell fate.

Kawamori D, Akiyama M, Hu J, Hambro B, Kulkarni RN.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:21-30. doi: 10.1111/j.1463-1326.2011.01442.x. Review.

PMID:
21824253
19.

Direct visualisation of peptide hormones in cultured pancreatic islet alpha- and beta-cells by intact-cell mass spectrometry.

Buchanan CM, Malik AS, Cooper GJ.

Rapid Commun Mass Spectrom. 2007;21(21):3452-8.

PMID:
17918213
20.

α-cell role in β-cell generation and regeneration.

Habener JF, Stanojevic V.

Islets. 2012 May-Jun;4(3):188-98. doi: 10.4161/isl.20500. Review.

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