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Items: 1 to 20 of 118

1.

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.

de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH.

J Biol Chem. 2014 May 30;289(22):15798-809. doi: 10.1074/jbc.M113.544346. Epub 2014 Apr 23.

2.

Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.

Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R.

J Biol Chem. 2009 Mar 6;284(10):6291-300. doi: 10.1074/jbc.M807791200. Epub 2008 Dec 15.

3.

FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.

Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):909-14. doi: 10.1161/ATVBAHA.108.178541. Epub 2009 Mar 26. Erratum in: Arterioscler Thromb Vasc Biol. 2009 Dec 1;29(12):e132.

4.

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

Parham KA, Zebol JR, Tooley KL, Sun WY, Moldenhauer LM, Cockshell MP, Gliddon BL, Moretti PA, Tigyi G, Pitson SM, Bonder CS.

FASEB J. 2015 Sep;29(9):3638-53. doi: 10.1096/fj.14-261289. Epub 2015 May 18.

5.

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM.

PLoS One. 2014 Dec 2;9(12):e113998. doi: 10.1371/journal.pone.0113998. eCollection 2014.

6.

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.

Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA.

FASEB J. 2003 Aug;17(11):1411-21.

PMID:
12890694
7.

Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.

El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA.

Mol Endocrinol. 2012 May;26(5):833-45. doi: 10.1210/me.2011-1261. Epub 2012 Mar 15.

8.

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Nègre-Salvayre A, Salvayre R, Augé N.

Biochim Biophys Acta. 2013 Aug;1831(8):1344-56. doi: 10.1016/j.bbalip.2013.04.014. Epub 2013 May 4.

PMID:
23651497
9.

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.

Leclercq TM, Moretti PA, Vadas MA, Pitson SM.

J Biol Chem. 2008 Apr 11;283(15):9606-14. doi: 10.1074/jbc.M708782200. Epub 2008 Feb 8.

10.

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.

El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM.

Mol Endocrinol. 2011 Dec;25(12):2144-56. doi: 10.1210/me.2011-0101. Epub 2011 Oct 20.

11.

De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells.

Berdyshev EV, Gorshkova IA, Usatyuk P, Zhao Y, Saatian B, Hubbard W, Natarajan V.

Cell Signal. 2006 Oct;18(10):1779-92. Epub 2006 Mar 10.

PMID:
16529909
12.

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM.

J Biol Chem. 2006 Oct 20;281(42):31399-407. Epub 2006 Aug 22.

13.

The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway.

Farnoud AM, Bryan AM, Kechichian T, Luberto C, Del Poeta M.

Infect Immun. 2015 Jul;83(7):2705-13. doi: 10.1128/IAI.00056-15. Epub 2015 Apr 20.

14.

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.

Yaghobian D, Don AS, Yaghobian S, Chen X, Pollock CA, Saad S.

Clin Exp Pharmacol Physiol. 2016 Jan;43(1):56-66. doi: 10.1111/1440-1681.12494.

PMID:
26414003
15.

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate.

Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Pitson SM, Wattenberg BW.

J Lipid Res. 2010 Sep;51(9):2546-59. doi: 10.1194/jlr.M004374. Epub 2010 Apr 12.

16.

Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.

Yan G, Chen S, You B, Sun J.

Cardiovasc Res. 2008 May 1;78(2):308-14. doi: 10.1093/cvr/cvn006. Epub 2008 Jan 10.

PMID:
18192241
17.

Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.

Garrido-Martín EM, Blanco FJ, Roquè M, Novensà L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C.

Circ Res. 2013 Jan 4;112(1):113-27. doi: 10.1161/CIRCRESAHA.112.275586. Epub 2012 Oct 9.

18.

The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.

Zebol JR, Hewitt NM, Moretti PA, Lynn HE, Lake JA, Li P, Vadas MA, Wattenberg BW, Pitson SM.

Int J Biochem Cell Biol. 2009 Apr;41(4):822-7. doi: 10.1016/j.biocel.2008.08.012. Epub 2008 Aug 14.

19.

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.

Guo Y, Fan Y, Zhang J, Lomberk GA, Zhou Z, Sun L, Mathison AJ, Garcia-Barrio MT, Zhang J, Zeng L, Li L, Pennathur S, Willer CJ, Rader DJ, Urrutia R, Chen YE.

J Clin Invest. 2015 Oct 1;125(10):3819-30. doi: 10.1172/JCI79048. Epub 2015 Sep 14.

20.

Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells.

Gratschev D, Löf C, Heikkilä J, Björkbom A, Sukumaran P, Hinkkanen A, Slotte JP, Törnquist K.

Endocrinology. 2009 Nov;150(11):5125-34. doi: 10.1210/en.2009-0288. Epub 2009 Oct 1.

PMID:
19797403

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