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Items: 1 to 20 of 152

1.

Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.

Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB.

J Med Chem. 2014 May 22;57(10):4382-96. doi: 10.1021/jm5004182. Epub 2014 May 7.

2.

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Hah JM, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2003 Apr 24;46(9):1661-9.

PMID:
12699384
3.

Structural basis for isoform-selective inhibition in nitric oxide synthase.

Poulos TL, Li H.

Acc Chem Res. 2013 Feb 19;46(2):390-8. doi: 10.1021/ar300175n. Epub 2012 Oct 2.

4.

Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.

Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5674-9. doi: 10.1016/j.bmcl.2013.08.034. Epub 2013 Aug 14.

5.

Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms.

Oliveira BL, Moreira IS, Fernandes PA, Ramos MJ, Santos I, Correia JD.

J Mol Model. 2013 Apr;19(4):1537-51. doi: 10.1007/s00894-012-1677-8. Epub 2012 Dec 21.

PMID:
23263357
6.

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2015 Nov 12;58(21):8694-712. doi: 10.1021/acs.jmedchem.5b01330. Epub 2015 Oct 27. Erratum in: J Med Chem. 2016 Feb 11;59(3):1246.

7.

Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.

Flinspach M, Li H, Jamal J, Yang W, Huang H, Silverman RB, Poulos TL.

Biochemistry. 2004 May 11;43(18):5181-7.

PMID:
15122883
8.

Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.

Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4504-4510. doi: 10.1016/j.bmcl.2014.07.079. Epub 2014 Aug 12.

9.

Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.

Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL.

Nat Struct Mol Biol. 2004 Jan;11(1):54-9. Epub 2003 Dec 29.

PMID:
14718923
11.

Discovery of a series of aminopiperidines as novel iNOS inhibitors.

Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. Epub 2007 Oct 25.

PMID:
18024030
12.

Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.

Ichimori K, Stuehr DJ, Atkinson RN, King SB.

J Med Chem. 1999 May 20;42(10):1842-8.

PMID:
10346937
13.

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB.

J Med Chem. 2006 Oct 19;49(21):6254-63.

14.

Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase.

Kubo S, Kurokawa Y, Doe I, Masuko T, Sekiguchi F, Kawabata A.

Toxicology. 2007 Nov 20;241(1-2):92-7. Epub 2007 Aug 19.

PMID:
17888559
15.

Novel inhibitors of neuronal nitric oxide synthase.

Di Giacomo C, Sorrenti V, Salerno L, Cardile V, Guerrera F, Siracusa MA, Avitabile M, Vanella A.

Exp Biol Med (Maywood). 2003 May;228(5):486-90.

PMID:
12709574
16.

Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.

Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH.

J Med Chem. 2005 Jul 28;48(15):4783-92.

PMID:
16033258
17.
18.

Fire ant venom alkaloid, isosolenopsin A, a potent and selective inhibitor of neuronal nitric oxide synthase.

Yi GB, McClendon D, Desaiah D, Goddard J, Lister A, Moffitt J, Meer RK, deShazo R, Lee KS, Rockhold RW.

Int J Toxicol. 2003 Mar-Apr;22(2):81-6.

PMID:
12745988
19.

Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .

Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL.

Biochemistry. 2010 Dec 28;49(51):10803-10. doi: 10.1021/bi1013479. Epub 2010 Dec 7.

20.

Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.

Carrión MD, Chayah M, Entrena A, López A, Gallo MA, Acuña-Castroviejo D, Camacho ME.

Bioorg Med Chem. 2013 Jul 15;21(14):4132-42. doi: 10.1016/j.bmc.2013.05.016. Epub 2013 May 17.

PMID:
23735830

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