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Korean red ginseng water extract restores impaired endothelial function by inhibiting arginase activity in aged mice.

Choi K, Yoon J, Lim HK, Ryoo S.

Korean J Physiol Pharmacol. 2014 Apr;18(2):95-101. doi: 10.4196/kjpp.2014.18.2.95. Epub 2014 Apr 3.


Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice.

Shin WS, Berkowitz DE, Ryoo SW.

Exp Mol Med. 2012 Oct 31;44(10):594-602. doi: 10.3858/emm.2012.44.10.068.


Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.

Kim YM, Namkoong S, Yun YG, Hong HD, Lee YC, Ha KS, Lee H, Kwon HJ, Kwon YG, Kim YM.

Biol Pharm Bull. 2007 Sep;30(9):1674-9.


Korean Red Ginseng protects endothelial cells from serum-deprived apoptosis by regulating Bcl-2 family protein dynamics and caspase S-nitrosylation.

Kim YM, Kim JH, Kwon HM, Lee DH, Won MH, Kwon YG, Kim YM.

J Ginseng Res. 2013 Oct;37(4):413-24. doi: 10.5142/jgr.2013.37.413.


A Novel Arginase Inhibitor Derived from Scutellavia indica Restored Endothelial Function in ApoE-Null Mice Fed a High-Cholesterol Diet.

Hwang HM, Lee JH, Min BS, Jeon BH, Hoe KL, Kim YM, Ryoo S.

J Pharmacol Exp Ther. 2015 Oct;355(1):57-65. doi: 10.1124/jpet.115.224592. Epub 2015 Aug 11.


Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice.

Nguyen MC, Ryoo S.

Korean J Physiol Pharmacol. 2017 Jan;21(1):83-90. doi: 10.4196/kjpp.2017.21.1.83. Epub 2016 Dec 21.


Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE.

J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008. Epub 2009 Aug 6.


Arginase inhibition by piceatannol-3'-O-β-D-glucopyranoside improves endothelial dysfunction via activation of endothelial nitric oxide synthase in ApoE-null mice fed a high-cholesterol diet.

Woo A, Shin W, Cuong TD, Min B, Lee JH, Jeon BH, Ryoo S.

Int J Mol Med. 2013 Apr;31(4):803-10. doi: 10.3892/ijmm.2013.1261. Epub 2013 Jan 30.


Inhibition of Hydrogen Sulfide-induced Angiogenesis and Inflammation in Vascular Endothelial Cells: Potential Mechanisms of Gastric Cancer Prevention by Korean Red Ginseng.

Choi KS, Song H, Kim EH, Choi JH, Hong H, Han YM, Hahm KB.

J Ginseng Res. 2012 Apr;36(2):135-45. doi: 10.5142/jgr.2012.36.2.135.


Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice.

Yoon J, Park M, Lee Jh, Min BS, Ryoo S.

Vascul Pharmacol. 2014 Mar;60(3):102-9. doi: 10.1016/j.vph.2014.01.006. Epub 2014 Feb 6.


Contribution of arginase activation to vascular dysfunction in cigarette smoking.

Sikka G, Pandey D, Bhuniya AK, Steppan J, Armstrong D, Santhanam L, Nyhan D, Berkowitz DE.

Atherosclerosis. 2013 Nov;231(1):91-4. doi: 10.1016/j.atherosclerosis.2013.08.026. Epub 2013 Sep 4.


Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis.

Jo S, Lee H, Kim S, Lee CH, Chung H.

J Ethnopharmacol. 2013 Nov 25;150(2):700-7. doi: 10.1016/j.jep.2013.09.036. Epub 2013 Oct 2.


p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesity.

Yu Y, Rajapakse AG, Montani JP, Yang Z, Ming XF.

Cardiovasc Diabetol. 2014 Jul 18;13:113. doi: 10.1186/s12933-014-0113-z.


Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.

Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y.

Cardiovasc Res. 2011 Nov 1;92(2):267-75. doi: 10.1093/cvr/cvr233. Epub 2011 Aug 29.


Mitochondrial arginase II constrains endothelial NOS-3 activity.

Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3317-24. Epub 2007 Sep 7.


Antiatherosclerotic effect of korean red ginseng extract involves regulator of g-protein signaling 5.

Im EJ, Yayeh T, Park SJ, Kim SH, Goo YK, Hong SB, Son YM, Kim SD, Rhee MH.

Evid Based Complement Alternat Med. 2014;2014:985174. doi: 10.1155/2014/985174. Epub 2014 Dec 24.


Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells.

Lim SW, Jin L, Luo K, Jin J, Yang CW.

Lab Invest. 2017 Jul 31. doi: 10.1038/labinvest.2017.75. [Epub ahead of print]


Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice.

Hwang E, Sun ZW, Lee TH, Shin HS, Park SY, Lee DG, Cho BG, Sohn H, Kwon OW, Kim SY, Yi TH.

J Ginseng Res. 2013 Oct;37(4):425-34. doi: 10.5142/jgr.2013.37.425.


Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.

Ketonen J, Pilvi T, Mervaala E.

Heart Vessels. 2010 May;25(3):254-62. doi: 10.1007/s00380-009-1182-x. Epub 2010 May 29.


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