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Interleukin-21 receptor deficiency increases the initial toll-like receptor 2 response but protects against joint pathology by reducing Th1 and Th17 cells during streptococcal cell wall arthritis.

Marijnissen RJ, Roeleveld DM, Young D, Nickerson-Nutter C, Abdollahi-Roodsaz S, Garcia de Aquino S, van de Loo FA, van Spriel AB, Boots AM, van den Berg WB, Koenders MI.

Arthritis Rheumatol. 2014 Apr;66(4):886-95. doi: 10.1002/art.38312.


Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.

Abdollahi-Roodsaz S, Joosten LA, Helsen MM, Walgreen B, van Lent PL, van den Bersselaar LA, Koenders MI, van den Berg WB.

Arthritis Rheum. 2008 Dec;58(12):3753-64. doi: 10.1002/art.24127.


Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis.

van den Brand BT, Abdollahi-Roodsaz S, Vermeij EA, Bennink MB, Arntz OJ, Rothlin CV, van den Berg WB, van de Loo FA.

Arthritis Rheum. 2013 Mar;65(3):671-80. doi: 10.1002/art.37786.


Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.

Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, Akira S, Lubberts E, van de Loo FA, van den Berg WB.

J Immunol. 2003 Dec 1;171(11):6145-53.


Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

Koenders MI, Kolls JK, Oppers-Walgreen B, van den Bersselaar L, Joosten LA, Schurr JR, Schwarzenberger P, van den Berg WB, Lubberts E.

Arthritis Rheum. 2005 Oct;52(10):3239-47.


Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice.

Abdollahi-Roodsaz S, van de Loo FA, Koenders MI, Helsen MM, Walgreen B, van den Bersselaar LA, Arntz OJ, Takahashi N, Joosten LA, van den Berg WB.

Arthritis Rheum. 2012 Jun;64(6):1838-47. doi: 10.1002/art.34328. Epub 2011 Dec 6.


Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis.

Veenbergen S, Bennink MB, de Hooge AS, Arntz OJ, Smeets RL, van den Berg WB, van de Loo FA.

Arthritis Rheum. 2008 Dec;58(12):3742-52. doi: 10.1002/art.24072.


GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis.

van Hamburg JP, Mus AM, de Bruijn MJ, de Vogel L, Boon L, Cornelissen F, Asmawidjaja P, Hendriks RW, Lubberts E.

Arthritis Rheum. 2009 Mar;60(3):750-9. doi: 10.1002/art.24329.


Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.

Young DA, Hegen M, Ma HL, Whitters MJ, Albert LM, Lowe L, Senices M, Wu PW, Sibley B, Leathurby Y, Brown TP, Nickerson-Nutter C, Keith JC Jr, Collins M.

Arthritis Rheum. 2007 Apr;56(4):1152-63.


IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.

Heinhuis B, Koenders MI, van de Loo FA, van Lent PL, Kim SH, Dinarello CA, Joosten LA, van den Berg WB.

Ann Rheum Dis. 2010 Oct;69(10):1866-72. doi: 10.1136/ard.2009.127399. Epub 2010 May 14.


Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.


T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17.

Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, van den Bersselaar LA, Oppers-Walgreen B, Koenders MI, van den Berg WB.

Arthritis Rheum. 2008 Jan;58(1):98-108. doi: 10.1002/art.23152.


Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation.

Marijnissen RJ, Koenders MI, Smeets RL, Stappers MH, Nickerson-Nutter C, Joosten LA, Boots AM, van den Berg WB.

Arthritis Rheum. 2011 Oct;63(10):2939-48. doi: 10.1002/art.30469.


A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis.

Arntz OJ, Geurts J, Veenbergen S, Bennink MB, van den Brand BT, Abdollahi-Roodsaz S, van den Berg WB, van de Loo FA.

Arthritis Res Ther. 2010;12(2):R61. doi: 10.1186/ar2974. Epub 2010 Apr 6.


An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.

Joosten LA, van De Loo FA, Lubberts E, Helsen MM, Netea MG, van Der Meer JW, Dinarello CA, van Den Berg WB.

J Immunol. 2000 Dec 1;165(11):6553-8.


Reduction of arthritis severity in protease-activated receptor-deficient mice.

Yang YH, Hall P, Little CB, Fosang AJ, Milenkovski G, Santos L, Xue J, Tipping P, Morand EF.

Arthritis Rheum. 2005 Apr;52(4):1325-32.


Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB.

Abdollahi-Roodsaz S, Koenders MI, Walgreen B, Bolscher J, Helsen MM, van den Bersselaar LA, van Lent PL, van de Loo FA, van den Berg WB.

Arthritis Rheum. 2013 Oct;65(10):2583-93. doi: 10.1002/art.38087.


Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.

de Hooge AS, van de Loo FA, Koenders MI, Bennink MB, Arntz OJ, Kolbe T, van den Berg WB.

Arthritis Rheum. 2004 Jun;50(6):2014-23.


Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis.

Corneth OB, Mus AM, Asmawidjaja PS, Klein Wolterink RG, van Nimwegen M, Brem MD, Hofman Y, Hendriks RW, Lubberts E.

Arthritis Rheumatol. 2014 Feb;66(2):340-9. doi: 10.1002/art.38229.

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