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Items: 1 to 20 of 186

1.

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway.

Pang Y, Si M, Sun B, Niu L, Xu X, Lu T, Yuan H, Lou H.

Food Chem Toxicol. 2014 Jul;69:163-74. doi: 10.1016/j.fct.2014.04.010. Epub 2014 Apr 18.

PMID:
24751974
3.
4.

Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.

Zhang DM, Liu JS, Deng LJ, Chen MF, Yiu A, Cao HH, Tian HY, Fung KP, Kurihara H, Pan JX, Ye WC.

Carcinogenesis. 2013 Jun;34(6):1331-42. doi: 10.1093/carcin/bgt060. Epub 2013 Feb 7.

PMID:
23393227
5.

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.

Zi D, Zhou ZW, Yang YJ, Huang L, Zhou ZL, He SM, He ZX, Zhou SF.

Int J Mol Sci. 2015 Nov 13;16(11):27228-51. doi: 10.3390/ijms161126018.

6.

Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells.

Che X, Yan H, Sun H, Dongol S, Wang Y, Lv Q, Jiang J.

Oncol Rep. 2016 Aug;36(2):1041-7. doi: 10.3892/or.2016.4840. Epub 2016 May 30.

PMID:
27277722
7.

4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway.

Liu M, Bamodu OA, Huang WC, Zucha MA, Lin YK, Wu ATH, Huang CC, Lee WH, Yuan CC, Hsiao M, Deng L, Tzeng YM, Yeh CT.

Toxicol Appl Pharmacol. 2017 Jun 15;325:48-60. doi: 10.1016/j.taap.2017.04.003. Epub 2017 Apr 10.

PMID:
28408137
8.

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway.

Liu M, Qi Z, Liu B, Ren Y, Li H, Yang G, Zhang Q.

Oncotarget. 2015 Sep 22;6(28):25281-94. doi: 10.18632/oncotarget.4634.

9.

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer.

Mabuchi S, Kuroda H, Takahashi R, Sasano T.

Gynecol Oncol. 2015 Apr;137(1):173-9. doi: 10.1016/j.ygyno.2015.02.003. Epub 2015 Feb 10. Review.

PMID:
25677064
10.

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V.

Autophagy. 2011 Jan;7(1):40-50. Epub 2011 Jan 1.

PMID:
20980833
11.

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines.

Bai H, Li H, Li W, Gui T, Yang J, Cao D, Shen K.

Oncotarget. 2015 Sep 22;6(28):25520-32. doi: 10.18632/oncotarget.4550.

12.

Endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance in human ovarian cancer cells.

Hu JL, Hu XL, Guo AY, Wang CJ, Wen YY, Cang SD.

Oncotarget. 2017 Jul 25;8(30):49380-49394. doi: 10.18632/oncotarget.17673.

13.

Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling.

Ren L, Cao QX, Zhai FR, Yang SQ, Zhang HX.

Pharm Biol. 2016 Nov;54(11):2377-2382. Epub 2016 Mar 17.

PMID:
26984021
14.

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells.

Singh BN, Kumar D, Shankar S, Srivastava RK.

Biochem Pharmacol. 2012 Nov 1;84(9):1154-63. doi: 10.1016/j.bcp.2012.08.007. Epub 2012 Aug 15.

PMID:
22902833
15.

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer.

Li H, Zeng J, Shen K.

Arch Gynecol Obstet. 2014 Dec;290(6):1067-78. doi: 10.1007/s00404-014-3377-3. Epub 2014 Aug 3. Review.

PMID:
25086744
16.

α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice.

Wang F, Ma H, Liu Z, Huang W, Xu X, Zhang X.

Biomed Pharmacother. 2017 Aug;92:672-680. doi: 10.1016/j.biopha.2017.05.129. Epub 2017 Jun 3.

PMID:
28582759
17.

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells.

Tsai JP, Lee CH, Ying TH, Lin CL, Lin CL, Hsueh JT, Hsieh YH.

Oncotarget. 2015 Oct 6;6(30):28851-66. doi: 10.18632/oncotarget.4767.

18.

Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.

Rajput S, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M.

PLoS One. 2013 Apr 17;8(4):e61342. doi: 10.1371/journal.pone.0061342. Print 2013.

19.

Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.

Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D.

Mol Cancer Ther. 2009 May;8(5):1157-68. doi: 10.1158/1535-7163.MCT-08-1008. Epub 2009 May 5.

20.

SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway.

Hong SW, Jung KH, Lee HS, Choi MJ, Son MK, Zheng HM, Hong SS.

Cancer Sci. 2012 Nov;103(11):1929-37. doi: 10.1111/j.1349-7006.2012.02409.x. Epub 2012 Sep 25. Erratum in: Cancer Sci. 2013 Oct;104(10):1389.

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