Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 69

1.

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.

Wagner R, Staiger H, Ullrich S, Stefan N, Fritsche A, Häring HU.

Mol Metab. 2014 Jan 22;3(3):261-7. doi: 10.1016/j.molmet.2014.01.001. eCollection 2014 Jun. Review.

2.

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.

Heni M, Ketterer C, Thamer C, Herzberg-Schäfer SA, Guthoff M, Stefan N, Machicao F, Staiger H, Fritsche A, Häring HU.

Diabetes. 2010 Dec;59(12):3247-52. doi: 10.2337/db10-0674. Epub 2010 Aug 29.

3.

Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans.

Wagner R, Kaiser G, Gerst F, Christiansen E, Due-Hansen ME, Grundmann M, Machicao F, Peter A, Kostenis E, Ulven T, Fritsche A, Häring HU, Ullrich S.

Diabetes. 2013 Jun;62(6):2106-11. doi: 10.2337/db12-1249. Epub 2013 Feb 1.

4.

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS.

Diabetes. 2010 Feb;59(2):479-85. doi: 10.2337/db09-1169. Epub 2009 Nov 23.

5.

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.

Saadi H, Nagelkerke N, Carruthers SG, Benedict S, Abdulkhalek S, Reed R, Lukic M, Nicholls MG.

Diabetes Res Clin Pract. 2008 Jun;80(3):392-8. doi: 10.1016/j.diabres.2008.01.008. Epub 2008 Feb 20.

PMID:
18282631
6.

Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

Bonetti S, Trombetta M, Malerba G, Boselli L, Trabetti E, Muggeo M, Stoico V, Negri C, Pignatti PF, Bonora E, Bonadonna RC.

J Clin Endocrinol Metab. 2011 Feb;96(2):E389-93. doi: 10.1210/jc.2010-1677. Epub 2010 Dec 15.

PMID:
21159844
7.

Variation in the FFAR1 gene modifies BMI, body composition and beta-cell function in overweight subjects: an exploratory analysis.

Walker CG, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TA, Frost GS; RISCK Study Group.

PLoS One. 2011 Apr 28;6(4):e19146. doi: 10.1371/journal.pone.0019146.

8.

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Loos RJ, Franks PW, Francis RW, Barroso I, Gribble FM, Savage DB, Ong KK, O'Rahilly S, Wareham NJ.

Diabetes. 2007 Jul;56(7):1943-7. Epub 2007 Apr 6.

9.

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.

10.

Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion.

Ordelheide AM, Gerst F, Rothfuss O, Heni M, Haas C, Thielker I, Herzberg-Schäfer S, Böhm A, Machicao F, Ullrich S, Stefan N, Fritsche A, Häring HU, Staiger H.

Mol Metab. 2013 Jun 17;2(3):243-55. doi: 10.1016/j.molmet.2013.06.003. eCollection 2013.

11.

Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study.

Delgado-Lista J, Perez-Martinez P, García-Rios A, Phillips CM, Williams CM, Gulseth HL, Helal O, Blaak EE, Kiec-Wilk B, Basu S, Drevon CA, Defoort C, Saris WH, Wybranska I, Riserus U, Lovegrove JA, Roche HM, Lopez-Miranda J.

Atherosclerosis. 2011 Jan;214(1):110-6. doi: 10.1016/j.atherosclerosis.2010.10.027. Epub 2010 Nov 3.

PMID:
21115178
12.

Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome.

Phillips CM, Goumidi L, Bertrais S, Field MR, McManus R, Hercberg S, Lairon D, Planells R, Roche HM.

J Nutr Biochem. 2012 Mar;23(3):239-44. doi: 10.1016/j.jnutbio.2010.11.020. Epub 2011 May 2.

PMID:
21543200
13.

Prevalence of the rs7903146C>T polymorphism in TCF7L2 gene for prediction of type 2 diabetes risk among Iranians of different ethnicities.

Allahdini M, Kamalidehghan B, Akbari L, Azadfar P, Rahmani A, Ahmadipour F, Meng GY, Masserrat A, Houshmand M.

Drug Des Devel Ther. 2015 Oct 28;9:5835-41. doi: 10.2147/DDDT.S82485. eCollection 2015.

14.

Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women.

Reyes-López R, Pérez-Luque E, Malacara JM.

Diabetes Metab Res Rev. 2014 Nov;30(8):701-6. doi: 10.1002/dmrr.2538.

PMID:
24639413
15.

[Correlation between TCF7L2 gene polymorphism and genetic susceptibility in women with gestational diabetes mellitus].

Shi X, Cai Q, Zou M, Shen Y.

Zhonghua Fu Chan Ke Za Zhi. 2014 Aug;49(8):588-93. Chinese.

PMID:
25354859
16.

Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children.

de Kort SW, Mook-Kanamori DO, Jaddoe VW, Hokken-Koelega AC.

Clin Endocrinol (Oxf). 2010 Jan;72(1):47-52. doi: 10.1111/j.1365-2265.2009.03635.x. Epub 2009 May 18.

PMID:
19473183
17.

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans.

Wagner R, Hieronimus A, Lamprinou A, Heni M, Hatziagelaki E, Ullrich S, Stefan N, Staiger H, Häring HU, Fritsche A.

Mol Metab. 2014 Jul 7;3(6):676-80. doi: 10.1016/j.molmet.2014.07.001. eCollection 2014 Sep.

18.

The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: insights into pathogenesis.

Sgariglia F, Pedrini E, Bradfield JP, Bhatti TR, D'Adamo P, Dormans JP, Gunawardena AT, Hakonarson H, Hecht JT, Sangiorgi L, Pacifici M, Enomoto-Iwamoto M, Grant SF.

Bone. 2015 Mar;72:123-7. doi: 10.1016/j.bone.2014.11.024. Epub 2014 Dec 9.

19.

Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition.

Matsuda-Nagasumi K, Takami-Esaki R, Iwachidow K, Yasuhara Y, Tanaka H, Ogi K, Nakata M, Yano T, Hinuma S, Taketomi S, Odaka H, Kaisho Y.

Diabetes Obes Metab. 2013 Jun;15(6):538-45. doi: 10.1111/dom.12065. Epub 2013 Feb 6.

PMID:
23331570
20.

TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.

Marquezine GF, Pereira AC, Sousa AG, Mill JG, Hueb WA, Krieger JE.

BMC Med Genet. 2008 Dec 4;9:106. doi: 10.1186/1471-2350-9-106.

Supplemental Content

Support Center