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The role of P2X7 receptor in PC12 cells after exposure to oxygen-glucose deprivation.

Fan B, Liu S, Xu C, Liu J, Kong F, Li G, Zhang C, Gao Y, Xu H, Yu S, Zheng C, Peng L, Song M, Wu B, Lv Q, Zou L, Ying M, Zhang X, Liang S.

Auton Neurosci. 2014 Oct;185:36-42. doi: 10.1016/j.autneu.2014.03.006. Epub 2014 Mar 30.


The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation.

Li G, Zou L, Xie W, Wen S, Xie Q, Gao Y, Xu C, Xu H, Liu S, Wang S, Xue Y, Wu B, Lv Q, Ying M, Zhang X, Liang S.

Purinergic Signal. 2016 Sep;12(3):479-87. doi: 10.1007/s11302-016-9513-8. Epub 2016 Apr 21.


The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.

Maraula G, Lana D, Coppi E, Gentile F, Mello T, Melani A, Galli A, Giovannini MG, Pedata F, Pugliese AM.

PLoS One. 2014 Dec 19;9(12):e115273. doi: 10.1371/journal.pone.0115273. eCollection 2014.


P2X₇-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells.

Grol MW, Zelner I, Dixon SJ.

Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E561-75. doi: 10.1152/ajpendo.00209.2011. Epub 2011 Dec 20.


P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats.

Chen S, Ma Q, Krafft PR, Chen Y, Tang J, Zhang J, Zhang JH.

Crit Care Med. 2013 Dec;41(12):e466-74. doi: 10.1097/CCM.0b013e31829a8246.


Inhibition of the P2X7 receptor reduces cystogenesis in PKD.

Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC.

J Am Soc Nephrol. 2011 Sep;22(9):1696-706. doi: 10.1681/ASN.2010070728. Epub 2011 Jun 2.


High fatty acids modulate P2X(7) expression and IL-6 release via the p38 MAPK pathway in PC12 cells.

Xu H, Wu B, Jiang F, Xiong S, Zhang B, Li G, Liu S, Gao Y, Xu C, Tu G, Peng H, Liang S, Xiong H.

Brain Res Bull. 2013 May;94:63-70. doi: 10.1016/j.brainresbull.2013.02.002. Epub 2013 Feb 21.


Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland.

Dartt DA, Hodges RR.

Invest Ophthalmol Vis Sci. 2011 May 1;52(6):3381-90. doi: 10.1167/iovs.11-7210.


Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7.

Hattori F, Ohshima Y, Seki S, Tsukimoto M, Sato M, Takenouchi T, Suzuki A, Takai E, Kitani H, Harada H, Kojima S.

Eur J Pharmacol. 2012 Nov 15;695(1-3):20-6. doi: 10.1016/j.ejphar.2012.09.001. Epub 2012 Sep 11.


IMM-H004, a novel courmarin derivative, protects against oxygen-and glucose-deprivation/restoration-induced apoptosis in PC12 cells.

Ji HJ, Wang DM, Hu JF, Sun MN, Li G, Li ZP, Wu DH, Liu G, Chen NH.

Eur J Pharmacol. 2014 Jan 15;723:259-66. doi: 10.1016/j.ejphar.2013.11.023. Epub 2013 Nov 28.


Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.

Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.


P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.

Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME.

Neuropharmacology. 2013 Oct;73:311-9. doi: 10.1016/j.neuropharm.2013.05.032. Epub 2013 Jun 12.


Activation of P2X7 receptors decreases the proliferation of murine luteal cells.

Wang J, Liu S, Nie Y, Wu B, Wu Q, Song M, Tang M, Xiao L, Xu P, Tan X, Zhang L, Li G, Liang S, Zhang C.

Reprod Fertil Dev. 2015 Nov;27(8):1262-71. doi: 10.1071/RD14381.


P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia.

Arbeloa J, Pérez-Samartín A, Gottlieb M, Matute C.

Neurobiol Dis. 2012 Mar;45(3):954-61. doi: 10.1016/j.nbd.2011.12.014. Epub 2011 Dec 11.


Ca(2+) spiking activity caused by the activation of store-operated Ca(2+) channels mediates TNF-α release from microglial cells under chronic purinergic stimulation.

Ikeda M, Tsuno S, Sugiyama T, Hashimoto A, Yamoto K, Takeuchi K, Kishi H, Mizuguchi H, Kohsaka SI, Yoshioka T.

Biochim Biophys Acta. 2013 Dec;1833(12):2573-2585. doi: 10.1016/j.bbamcr.2013.06.022. Epub 2013 Jul 2.


ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation.

Zou J, Vetreno RP, Crews FT.

Glia. 2012 Apr;60(4):661-73. doi: 10.1002/glia.22302. Epub 2012 Feb 1.


LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury.

Zou L, Tu G, Xie W, Wen S, Xie Q, Liu S, Li G, Gao Y, Xu H, Wang S, Xue Y, Wu B, Lv Q, Ying M, Zhang X, Liang S.

Purinergic Signal. 2016 Mar;12(1):127-37. doi: 10.1007/s11302-015-9486-z. Epub 2015 Dec 2.


P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes.

Barros-Barbosa AR, Lobo MG, Ferreirinha F, Correia-de-Sá P, Cordeiro JM.

Neuroscience. 2015 Oct 15;306:74-90. doi: 10.1016/j.neuroscience.2015.08.026. Epub 2015 Aug 20.


Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells.

Nakazato R, Takarada T, Yamamoto T, Hotta S, Hinoi E, Yoneda Y.

J Pharmacol Sci. 2011;116(4):350-61. Epub 2011 Jul 9.

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