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Items: 1 to 20 of 108


Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation.

Al-Shboul O, Nalli AD, Kumar DP, Zhou R, Mahavadi S, Kuemmerle JF, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1129-41. doi: 10.1152/ajpcell.00021.2014. Epub 2014 Apr 16.


Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-κB/AMP-activated kinase/myosin light chain kinase pathway.

Nalli AD, Kumar DP, Mahavadi S, Al-Shboul O, Alkahtani R, Kuemmerle JF, Grider JR, Murthy KS.

J Pharmacol Exp Ther. 2014 Jul;350(1):89-98. doi: 10.1124/jpet.113.212522. Epub 2014 Apr 25.


Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta.

Hu W, Mahavadi S, Li F, Murthy KS.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1991-2000. Epub 2007 Oct 24.


Role of Ca2+-sensitization in attenuated carbachol-induced contraction of the colon in a rat model of colitis.

Al-Jarallah A, Khan I, Oriowo MA.

Eur J Pharmacol. 2008 Jan 28;579(1-3):365-73. Epub 2007 Nov 1.


Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.

Mahavadi S, Nalli AD, Kumar DP, Hu W, Kuemmerle JF, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C402-11. doi: 10.1152/ajpcell.00123.2014. Epub 2014 Jun 18.


Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.

Mizuno Y, Isotani E, Huang J, Ding H, Stull JT, Kamm KE.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C358-64. doi: 10.1152/ajpcell.90645.2007. Epub 2008 Jun 4.


Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.

Huang J, Zhou H, Mahavadi S, Sriwai W, Lyall V, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.


Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.

Mahavadi S, Bhattacharya S, Kumar DP, Clay C, Ross G, Akbarali HI, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74. doi: 10.1152/ajpgi.00165.2013. Epub 2013 Oct 24.


Immune/Inflammatory Response and Hypocontractility of Rabbit Colonic Smooth Muscle After TNBS-Induced Colitis.

Zhang Y, Li F, Wang H, Yin C, Huang J, Mahavadi S, Murthy KS, Hu W.

Dig Dis Sci. 2016 Jul;61(7):1925-40. doi: 10.1007/s10620-016-4078-5. Epub 2016 Feb 15.


Role of TNF-alpha in muscularis inflammation and motility disorder in a TNBS-induced colitis model: clues from TNF-alpha-deficient mice.

Kinoshita K, Hori M, Fujisawa M, Sato K, Ohama T, Momotani E, Ozaki H.

Neurogastroenterol Motil. 2006 Jul;18(7):578-88.


Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.

Ihara E, Moffat L, Ostrander J, Walsh MP, MacDonald JA.

Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G699-710. Epub 2007 Jul 26.


ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction.

Ihara E, Yu Q, Chappellaz M, MacDonald JA.

Neurogastroenterol Motil. 2015 Jan;27(1):135-46. doi: 10.1111/nmo.12491.


Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB.

Hersch E, Huang J, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1209-18.


The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.

Ihara E, Chappellaz M, Turner SR, MacDonald JA.

Neurogastroenterol Motil. 2012 Jan;24(1):e15-26. doi: 10.1111/j.1365-2982.2011.01821.x. Epub 2011 Nov 16.


Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase.

Wang T, Kendig DM, Smolock EM, Moreland RS.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1534-42. doi: 10.1152/ajprenal.00095.2009. Epub 2009 Sep 30.


Inflammatory gene expression by human colonic smooth muscle cells.

Salinthone S, Singer CA, Gerthoffer WT.

Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G627-37. Epub 2004 Apr 29.


Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.

Anderson CD Jr, Kendig DM, Al-Qudah M, Mahavadi S, Murthy KS, Grider JR.

J Smooth Muscle Res. 2014;50:103-19. doi: 10.1540/jsmr.50.103.


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