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Items: 1 to 20 of 212


Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes.

Inturi S, Tewari-Singh N, Agarwal C, White CW, Agarwal R.

Mutat Res. 2014 May-Jun;763-764:53-63. doi: 10.1016/j.mrfmmm.2014.04.002. Epub 2014 Apr 13.


Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators.

Kumar D, Tewari-Singh N, Agarwal C, Jain AK, Inturi S, Kant R, White CW, Agarwal R.

Toxicol Lett. 2015 Jun 15;235(3):161-71. doi: 10.1016/j.toxlet.2015.04.006. Epub 2015 Apr 16.


Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks.

Dong J, Zhang T, Ren Y, Wang Z, Ling CC, He F, Li GC, Wang C, Wen B.

Oncotarget. 2017 Apr 4;8(14):22662-22673. doi: 10.18632/oncotarget.15153.


Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice.

Yang ES, Wang H, Jiang G, Nowsheen S, Fu A, Hallahan DE, Xia F.

J Clin Invest. 2009 May;119(5):1124-35.


The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression.

Bee L, Fabris S, Cherubini R, Mognato M, Celotti L.

PLoS One. 2013 Jul 11;8(7):e69061. doi: 10.1371/journal.pone.0069061. Print 2013.


Mechanisms of DNA double strand break repair and chromosome aberration formation.

Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.

Cytogenet Genome Res. 2004;104(1-4):14-20. Review.


Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro.

Lian H, Cui J, Wang Y, Liu J, Wang J, Shen H, Xing L, Wang J, Yan X, Zhang X.

Toxicol Lett. 2014 Apr 21;226(2):214-21. doi: 10.1016/j.toxlet.2014.02.002. Epub 2014 Feb 10.


Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.

Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R.

Cancer Sci. 2016 Sep;107(9):1250-5. doi: 10.1111/cas.12998. Epub 2016 Sep 1.


DNA-PK promotes the survival of young neurons in the embryonic mouse retina.

Baleriola J, Suárez T, de la Rosa EJ.

Cell Death Differ. 2010 Nov;17(11):1697-706. doi: 10.1038/cdd.2010.46. Epub 2010 May 7.


Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.

Klammer H, Kadhim M, Iliakis G.

Cancer Res. 2010 Nov 1;70(21):8498-506. doi: 10.1158/0008-5472.CAN-10-1181. Epub 2010 Sep 22.


DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells.

Urushihara Y, Kobayashi J, Matsumoto Y, Komatsu K, Oda S, Mitani H.

Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):131-6. doi: 10.1016/j.bbrc.2012.10.128. Epub 2012 Nov 7.


Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair.

Gustafsson AS, Abramenkovs A, Stenerlöw B.

Mutat Res. 2014 Nov;769:1-10. doi: 10.1016/j.mrfmmm.2014.06.004. Epub 2014 Jun 22.


Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization.

Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R.

Cornea. 2016 Feb;35(2):257-66. doi: 10.1097/ICO.0000000000000685.


Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells.

de Campos-Nebel M, Larripa I, González-Cid M.

Mutat Res. 2008 Nov 10;646(1-2):8-16. doi: 10.1016/j.mrfmmm.2008.08.013. Epub 2008 Sep 4.


p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.

Gong L, Gong H, Pan X, Chang C, Ou Z, Ye S, Yin L, Yang L, Tao T, Zhang Z, Liu C, Lane DP, Peng J, Chen J.

Cell Res. 2015 Mar;25(3):351-69. doi: 10.1038/cr.2015.22. Epub 2015 Feb 20.


[Analysis of irradiation-induced repair foci in mouse embryonic stem cells].

Suvorova II, Pospelov VA.

Tsitologiia. 2014;56(5):340-5. Russian.


Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.

Middleton FK, Patterson MJ, Elstob CJ, Fordham S, Herriott A, Wade MA, McCormick A, Edmondson R, May FE, Allan JM, Pollard JR, Curtin NJ.

Oncotarget. 2015 Oct 20;6(32):32396-409. doi: 10.18632/oncotarget.6136.


Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin.

Inturi S, Tewari-Singh N, Jain AK, Roy S, White CW, Agarwal R.

Toxicology. 2013 Sep 15;311(3):184-90. doi: 10.1016/j.tox.2013.06.013. Epub 2013 Jul 8.

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