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Items: 1 to 20 of 257

1.

Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.

Sonneveld R, van der Vlag J, Baltissen MP, Verkaart SA, Wetzels JF, Berden JH, Hoenderop JG, Nijenhuis T.

Am J Pathol. 2014 Jun;184(6):1715-26. doi: 10.1016/j.ajpath.2014.02.008. Epub 2014 Apr 13.

PMID:
24731445
2.

Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.

Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, van Goor H, Kistler AD, Bakker M, Bindels RJ, de Boer RA, Möller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, van der Vlag J.

Am J Pathol. 2011 Oct;179(4):1719-32. doi: 10.1016/j.ajpath.2011.06.033. Epub 2011 Aug 11.

3.

Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.

Sonneveld R, Ferrè S, Hoenderop JG, Dijkman HB, Berden JH, Bindels RJ, Wetzels JF, van der Vlag J, Nijenhuis T.

Am J Pathol. 2013 Apr;182(4):1196-204. doi: 10.1016/j.ajpath.2012.12.011. Epub 2013 Feb 4.

PMID:
23385000
4.

Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels.

Ilatovskaya DV, Levchenko V, Lowing A, Shuyskiy LS, Palygin O, Staruschenko A.

Sci Rep. 2015 Dec 10;5:17637. doi: 10.1038/srep17637.

5.

Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes.

Li Z, Xu J, Xu P, Liu S, Yang Z.

Cell Prolif. 2013 Feb;46(1):76-85. doi: 10.1111/cpr.12010.

PMID:
23294354
6.

Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.

Möller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J.

J Am Soc Nephrol. 2007 Jan;18(1):29-36. Epub 2006 Dec 13.

7.

Inhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1.

Huang H, You Y, Lin X, Tang C, Gu X, Huang M, Qin Y, Tan J, Huang F.

Cell Physiol Biochem. 2017;41(1):163-172. doi: 10.1159/000455985. Epub 2017 Jan 18.

8.

The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats.

Zhang X, Song Z, Guo Y, Zhou M.

Mol Cell Biochem. 2015 Jan;399(1-2):155-65. doi: 10.1007/s11010-014-2242-9. Epub 2014 Oct 9.

PMID:
25292315
9.

Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition.

Sonneveld R, Hoenderop JG, Isidori AM, Henique C, Dijkman HB, Berden JH, Tharaux PL, van der Vlag J, Nijenhuis T.

J Am Soc Nephrol. 2017 May;28(5):1491-1505. doi: 10.1681/ASN.2015080885. Epub 2016 Nov 28.

PMID:
27895156
10.

Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6.

Yao XM, Liu YJ, Wang YM, Wang H, Zhu BB, Liang YP, Yao WG, Yu H, Wang NS, Zhang XM, Peng W.

Mol Med Rep. 2016 Jun;13(6):5149-56. doi: 10.3892/mmr.2016.5167. Epub 2016 Apr 22.

PMID:
27109610
11.

High glucose-induced apoptosis in cultured podocytes involves TRPC6-dependent calcium entry via the RhoA/ROCK pathway.

Yang H, Zhao B, Liao C, Zhang R, Meng K, Xu J, Jiao J.

Biochem Biophys Res Commun. 2013 May 3;434(2):394-400. doi: 10.1016/j.bbrc.2013.03.087. Epub 2013 Apr 6.

PMID:
23570668
12.

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production.

Toyonaga J, Tsuruya K, Ikeda H, Noguchi H, Yotsueda H, Fujisaki K, Hirakawa M, Taniguchi M, Masutani K, Iida M.

Nephrol Dial Transplant. 2011 Aug;26(8):2475-84. doi: 10.1093/ndt/gfq750. Epub 2011 Jan 10.

PMID:
21220752
13.

TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.

Zhang H, Ding J, Fan Q, Liu S.

Exp Biol Med (Maywood). 2009 Sep;234(9):1029-36. doi: 10.3181/0901-RM-11. Epub 2009 Jun 22.

PMID:
19546355
14.

Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria.

Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J.

J Am Soc Nephrol. 2016 Nov;27(11):3308-3319. Epub 2016 Mar 28.

PMID:
27020855
15.

ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.

Roshanravan H, Dryer SE.

Am J Physiol Renal Physiol. 2014 May 1;306(9):F1088-97. doi: 10.1152/ajprenal.00661.2013. Epub 2014 Feb 19.

16.

Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.

Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J.

J Biol Chem. 2013 Dec 20;288(51):36598-609. doi: 10.1074/jbc.M113.488122. Epub 2013 Nov 5.

17.

TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

Ilatovskaya DV, Staruschenko A.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F393-7. doi: 10.1152/ajprenal.00186.2015. Epub 2015 Jun 17. Review.

18.

Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes.

Graham S, Ding M, Sours-Brothers S, Yorio T, Ma JX, Ma R.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1381-90. Epub 2007 Aug 15.

19.

Activation of a local renin angiotensin system in podocytes by glucose.

Durvasula RV, Shankland SJ.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F830-9. doi: 10.1152/ajprenal.00266.2007. Epub 2008 Jan 23.

20.

Gq signaling causes glomerular injury by activating TRPC6.

Wang L, Jirka G, Rosenberg PB, Buckley AF, Gomez JA, Fields TA, Winn MP, Spurney RF.

J Clin Invest. 2015 May;125(5):1913-26. doi: 10.1172/JCI76767. Epub 2015 Apr 6.

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