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Items: 1 to 20 of 64

1.

Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid.

Murza A, Belleville K, Longpré JM, Sarret P, Marsault É.

Biopolymers. 2014 Jul;102(4):297-303. doi: 10.1002/bip.22498.

PMID:
24728860
2.

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.

ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13.

PMID:
22170700
3.

Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity.

Hamada J, Baasanjav A, Ono N, Murata K, Kako K, Ishida J, Fukamizu A.

Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H931-41. doi: 10.1152/ajpheart.00703.2013. Epub 2015 Feb 13.

4.

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

J Med Chem. 2017 Jul 27;60(14):6408-6427. doi: 10.1021/acs.jmedchem.7b00723. Epub 2017 Jul 7.

PMID:
28685579
5.

The apelinergic system: sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice.

Butruille L, Drougard A, Knauf C, Moitrot E, Valet P, Storme L, Deruelle P, Lesage J.

Peptides. 2013 Aug;46:94-101. doi: 10.1016/j.peptides.2013.05.013. Epub 2013 Jun 5.

PMID:
23747606
6.

Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin.

Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, Kitada C, Honda S, Kurokawa T, Onda H, Nishimura O, Fujino M.

J Biol Chem. 2000 Jul 14;275(28):21061-7.

7.

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

Fischer C, Lamer T, Wang W, McKinnie SMK, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

Eur J Med Chem. 2019 Mar 15;166:119-124. doi: 10.1016/j.ejmech.2019.01.040. Epub 2019 Jan 18.

PMID:
30690406
8.

Putative role for apelin in pressure/volume homeostasis and cardiovascular disease.

Charles CJ.

Cardiovasc Hematol Agents Med Chem. 2007 Jan;5(1):1-10. Review.

PMID:
17266543
9.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.

J Med Chem. 2015 Mar 12;58(5):2431-40. doi: 10.1021/jm501916k. Epub 2015 Feb 24.

PMID:
25668242
10.

Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ.

Chu J, Zhang H, Huang X, Lin Y, Shen T, Chen B, Man Y, Wang S, Li J.

PLoS One. 2013;8(2):e57231. doi: 10.1371/journal.pone.0057231. Epub 2013 Feb 21. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/15dd6d58-5cea-4252-94a6-52778c6ee55e.

11.

Central and peripheral cardiovascular actions of apelin in conscious rats.

Kagiyama S, Fukuhara M, Matsumura K, Lin Y, Fujii K, Iida M.

Regul Pept. 2005 Feb 15;125(1-3):55-9.

PMID:
15582714
12.

Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats.

Zhang CR, Xia CM, Jiang MY, Zhu MX, Zhu JM, Du DS, Liu M, Wang J, Zhu DN.

Brain Res Bull. 2013 Aug;97:53-62. doi: 10.1016/j.brainresbull.2013.05.013. Epub 2013 Jun 7.

PMID:
23751198
13.

Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.

Zhang Y, Maitra R, Harris DL, Dhungana S, Snyder R, Runyon SP.

Bioorg Med Chem. 2014 Jun 1;22(11):2992-7. doi: 10.1016/j.bmc.2014.04.001. Epub 2014 Apr 13.

PMID:
24755525
14.

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.

O'Carroll AM, Lolait SJ, Harris LE, Pope GR.

J Endocrinol. 2013 Sep 11;219(1):R13-35. doi: 10.1530/JOE-13-0227. Print 2013 Oct. Review.

PMID:
23943882
15.

Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure.

Chong KS, Gardner RS, Morton JJ, Ashley EA, McDonagh TA.

Eur J Heart Fail. 2006 Jun;8(4):355-60. Epub 2006 Feb 7.

16.

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.

Chen X, Bai B, Tian Y, Du H, Chen J.

J Biol Chem. 2014 Nov 7;289(45):31173-87. doi: 10.1074/jbc.M114.574020. Epub 2014 Sep 30.

17.

Apelin-13 and APJ in paraventricular nucleus contribute to hypertension via sympathetic activation and vasopressin release in spontaneously hypertensive rats.

Zhang F, Sun HJ, Xiong XQ, Chen Q, Li YH, Kang YM, Wang JJ, Gao XY, Zhu GQ.

Acta Physiol (Oxf). 2014 Sep;212(1):17-27. doi: 10.1111/apha.12342. Epub 2014 Jul 18.

PMID:
24995933
18.

Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ.

Fan X, Zhou N, Zhang X, Mukhtar M, Lu Z, Fang J, DuBois GC, Pomerantz RJ.

Biochemistry. 2003 Sep 2;42(34):10163-8.

PMID:
12939143
19.

Apelin: a novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target.

Falcão-Pires I, Leite-Moreira AF.

Rev Port Cardiol. 2005 Oct;24(10):1263-76. Review. English, Portuguese.

PMID:
16398242
20.

New structural insights into the apelin receptor: identification of key residues for apelin binding.

Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, Iturrioz X.

FASEB J. 2015 Jan;29(1):314-22. doi: 10.1096/fj.14-256339. Epub 2014 Oct 30.

PMID:
25359495

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