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Items: 1 to 20 of 101

1.

The role of distant mutations and allosteric regulation on LovD active site dynamics.

Jiménez-Osés G, Osuna S, Gao X, Sawaya MR, Gilson L, Collier SJ, Huisman GW, Yeates TO, Tang Y, Houk KN.

Nat Chem Biol. 2014 Jun;10(6):431-6. doi: 10.1038/nchembio.1503. Epub 2014 Apr 13.

2.

Acyltransferase mediated polyketide release from a fungal megasynthase.

Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y.

J Am Chem Soc. 2009 Jun 24;131(24):8388-9. doi: 10.1021/ja903203g.

3.

Molecular dynamics explorations of active site structure in designed and evolved enzymes.

Osuna S, Jiménez-Osés G, Noey EL, Houk KN.

Acc Chem Res. 2015 Apr 21;48(4):1080-9. doi: 10.1021/ar500452q. Epub 2015 Mar 4.

PMID:
25738880
4.

Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y.

Chem Biol. 2006 Nov;13(11):1161-9.

5.

Directed evolution and structural characterization of a simvastatin synthase.

Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y.

Chem Biol. 2009 Oct 30;16(10):1064-74. doi: 10.1016/j.chembiol.2009.09.017.

6.

Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

Auclair K, Kennedy J, Hutchinson CR, Vederas JC.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1527-31.

PMID:
11412974
7.

Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR.

Science. 1999 May 21;284(5418):1368-72.

8.

Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases.

Hutchinson CR, Kennedy J, Park C, Kendrew S, Auclair K, Vederas J.

Antonie Van Leeuwenhoek. 2000 Dec;78(3-4):287-95. Review.

PMID:
11386351
9.

The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA.

Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK.

FEBS J. 2013 Jul;280(13):3160-75. doi: 10.1111/febs.12150. Epub 2013 Feb 15.

10.

Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.

Sorensen JL, Auclair K, Kennedy J, Hutchinson CR, Vederas JC.

Org Biomol Chem. 2003 Jan 7;1(1):50-9.

PMID:
12929390
11.

Origins of stereoselectivity in evolved ketoreductases.

Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7065-72. doi: 10.1073/pnas.1507910112. Epub 2015 Dec 7.

12.

The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis.

Sasaki H, Kubota K, Lee WC, Ohtsuka J, Kojima M, Iwata S, Nakagawa A, Takahashi K, Tanokura M.

J Biochem. 2012 Jul;152(1):45-52. doi: 10.1093/jb/mvs050. Epub 2012 May 7.

PMID:
22569035
13.

Biotechnological production and applications of statins.

Barrios-González J, Miranda RU.

Appl Microbiol Biotechnol. 2010 Jan;85(4):869-83. doi: 10.1007/s00253-009-2239-6. Epub 2009 Oct 10. Review.

PMID:
19820926
14.
15.

Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release.

Moriguchi T, Kezuka Y, Nonaka T, Ebizuka Y, Fujii I.

J Biol Chem. 2010 May 14;285(20):15637-43. doi: 10.1074/jbc.M110.107391. Epub 2010 Mar 19.

16.

X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

Shishova EY, Di Costanzo L, Cane DE, Christianson DW.

Biochemistry. 2007 Feb 20;46(7):1941-51. Epub 2007 Jan 30.

17.

Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap.

Corbi-Verge C, Marinelli F, Zafra-Ruano A, Ruiz-Sanz J, Luque I, Faraldo-Gómez JD.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3372-80. doi: 10.1073/pnas.1303966110. Epub 2013 Aug 19.

18.

Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase.

Chen Q, Luan ZJ, Cheng X, Xu JH.

Biochemistry. 2015 Mar 10;54(9):1841-8. doi: 10.1021/bi5015612. Epub 2015 Mar 2.

PMID:
25711934
19.

Protein dynamics in a family of laboratory evolved thermophilic enzymes.

Wintrode PL, Zhang D, Vaidehi N, Arnold FH, Goddard WA 3rd.

J Mol Biol. 2003 Mar 28;327(3):745-57.

PMID:
12634066
20.

Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus.

Jensen MH, Otten H, Christensen U, Borchert TV, Christensen LL, Larsen S, Leggio LL.

J Mol Biol. 2010 Nov 19;404(1):100-11. doi: 10.1016/j.jmb.2010.09.013. Epub 2010 Sep 17.

PMID:
20851126

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