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Items: 1 to 20 of 105

1.

Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.

Coulombe F, Jaworska J, Verway M, Tzelepis F, Massoud A, Gillard J, Wong G, Kobinger G, Xing Z, Couture C, Joubert P, Fritz JH, Powell WS, Divangahi M.

Immunity. 2014 Apr 17;40(4):554-68. doi: 10.1016/j.immuni.2014.02.013. Epub 2014 Apr 10.

2.

Prostaglandin E2: the villain in the host response to influenza virus.

Full F, Gack MU.

Immunity. 2014 Apr 17;40(4):453-4. doi: 10.1016/j.immuni.2014.03.008.

3.

Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

Samuchiwal SK, Balestrieri B, Raff H, Boyce JA.

J Biol Chem. 2017 May 19;292(20):8195-8206. doi: 10.1074/jbc.M116.769422. Epub 2017 Mar 24.

4.

Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice.

Wei B, Cai L, Sun D, Wang Y, Wang C, Chai X, Xie F, Su M, Ding F, Liu J, Yang J, Guan Y, Liu X.

Molecules. 2014 Apr 21;19(4):4967-85. doi: 10.3390/molecules19044967.

5.

Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation.

Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1049-58. doi: 10.1161/ATVBAHA.110.222356. Epub 2011 Feb 10.

PMID:
21311040
6.

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.

Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, von Knethen A, Weigert A, Brüne B.

Oncotarget. 2015 Apr 30;6(12):10284-96.

7.

Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.

Nakano Y, Kuroda E, Kito T, Uematsu S, Akira S, Yokota A, Nishizawa S, Yamashita U.

J Neurosurg. 2008 Feb;108(2):311-9. doi: 10.3171/JNS/2008/108/2/0311.

PMID:
18240928
8.

Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions.

Yamamoto E, Izawa T, Juniantito V, Kuwamura M, Sugiura K, Takeuchi T, Yamate J.

Histol Histopathol. 2010 Aug;25(8):995-1007. doi: 10.14670/HH-25.995.

PMID:
20552550
9.

Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

Wan M, Tang X, Rekha RS, Muvva SSVJR, Brighenti S, Agerberth B, Haeggström JZ.

FASEB J. 2018 May;32(5):2827-2840. doi: 10.1096/fj.201701308. Epub 2018 Jan 17.

PMID:
29401596
10.

Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.

Boulet L, Ouellet M, Bateman KP, Ethier D, Percival MD, Riendeau D, Mancini JA, Méthot N.

J Biol Chem. 2004 May 28;279(22):23229-37. Epub 2004 Mar 11.

11.

Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection.

Kroetz DN, Allen RM, Schaller MA, Cavallaro C, Ito T, Kunkel SL.

PLoS Pathog. 2015 Dec 28;11(12):e1005338. doi: 10.1371/journal.ppat.1005338. eCollection 2015 Dec.

12.

Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.

Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ.

Prostaglandins Leukot Essent Fatty Acids. 2013 Oct;89(5):351-8. doi: 10.1016/j.plefa.2013.08.003. Epub 2013 Aug 30.

13.

Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells.

Kay LJ, Gilbert M, Pullen N, Skerratt S, Farrington J, Seward EP, Peachell PT.

Clin Exp Allergy. 2013 Jul;43(7):741-51. doi: 10.1111/cea.12142.

PMID:
23786281
14.

Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro.

Park JH, Park EB, Lee JY, Min JY.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):848-55. doi: 10.1016/j.bbrc.2015.11.129. Epub 2015 Dec 7.

PMID:
26673392
15.

E prostanoid 2 (EP2)/EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin E2.

Okano M, Sugata Y, Fujiwara T, Matsumoto R, Nishibori M, Shimizu K, Maeda M, Kimura Y, Kariya S, Hattori H, Yokoyama M, Kino K, Nishizaki K.

Immunology. 2006 Jul;118(3):343-52.

16.

Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4.

Holt DM, Ma X, Kundu N, Collin PD, Fulton AM.

J Immunother. 2012 Feb-Mar;35(2):179-88. doi: 10.1097/CJI.0b013e318247a5e9.

17.

Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4.

Shen L, Liu Y.

Int Immunopharmacol. 2015 Sep;28(1):376-81. doi: 10.1016/j.intimp.2015.06.026. Epub 2015 Jun 27.

PMID:
26122137
18.
19.

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death.

Chen M, Divangahi M, Gan H, Shin DS, Hong S, Lee DM, Serhan CN, Behar SM, Remold HG.

J Exp Med. 2008 Nov 24;205(12):2791-801. doi: 10.1084/jem.20080767. Epub 2008 Oct 27.

20.

Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.

Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y.

J Neurochem. 2005 Sep;94(6):1546-58. Epub 2005 Jul 5.

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