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Items: 1 to 20 of 98

1.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.

2.

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Tamble CM, St Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS.

Mol Biosyst. 2011 Jun;7(6):2019-30. doi: 10.1039/c0mb00298d.

3.

Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast.

Zhang F, Gao B, Xu L, Li C, Hao D, Zhang S, Zhou M, Su F, Chen X, Zhi H, Li X.

PLoS One. 2013;8(1):e53581. doi: 10.1371/journal.pone.0053581.

4.

Utilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans.

Silberberg Y, Kupiec M, Sharan R.

Sci Rep. 2016 Mar 30;6:23703. doi: 10.1038/srep23703.

5.

Chemical genetic and chemogenomic analysis in yeast.

Coorey NV, Sampson LD, Barber JM, Bellows DS.

Methods Mol Biol. 2014;1205:169-86. doi: 10.1007/978-1-4939-1363-3_11.

PMID:
25213245
6.

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jaramillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW.

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):793-8.

7.

Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics.

Jaime MD, Lopez-Llorca LV, Conesa A, Lee AY, Proctor M, Heisler LE, Gebbia M, Giaever G, Westwood JT, Nislow C.

BMC Genomics. 2012 Jun 22;13:267. doi: 10.1186/1471-2164-13-267.

8.

Genetic Screens for Determination of Mechanism of Action.

Gay-Andrieu F, Alex D, Calderone R.

Methods Mol Biol. 2016;1356:165-72. doi: 10.1007/978-1-4939-3052-4_12.

PMID:
26519072
9.

Exploring gene function and drug action using chemogenomic dosage assays.

Ericson E, Hoon S, St Onge RP, Giaever G, Nislow C.

Methods Enzymol. 2010;470:233-55. doi: 10.1016/S0076-6879(10)70010-0.

PMID:
20946813
10.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR.

Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004.

11.

A drug similarity network for understanding drug mechanism of action.

Karabulut NP, Akhmedov M, Cokol M.

J Bioinform Comput Biol. 2014 Apr;12(2):1441007. doi: 10.1142/S0219720014410078.

PMID:
24712534
12.

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C.

PLoS Genet. 2008 Aug 8;4(8):e1000151. doi: 10.1371/journal.pgen.1000151.

13.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
14.

Cell-based high-content screening of small-molecule libraries.

Korn K, Krausz E.

Curr Opin Chem Biol. 2007 Oct;11(5):503-10. Review.

PMID:
17931958
15.

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Singh-Babak SD, Shekhar T, Smith AM, Giaever G, Nislow C, Cowen LE.

Mol Biosyst. 2012 Oct;8(10):2575-84. doi: 10.1039/c2mb25107h.

PMID:
22751784
16.

A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae.

Arita A, Zhou X, Ellen TP, Liu X, Bai J, Rooney JP, Kurtz A, Klein CB, Dai W, Begley TJ, Costa M.

BMC Genomics. 2009 Nov 15;10:524. doi: 10.1186/1471-2164-10-524.

18.

Target identification and mechanism of action in chemical biology and drug discovery.

Schenone M, Dančík V, Wagner BK, Clemons PA.

Nat Chem Biol. 2013 Apr;9(4):232-40. doi: 10.1038/nchembio.1199. Review.

PMID:
23508189
19.

Chemogenomics and biotechnology.

Wuster A, Madan Babu M.

Trends Biotechnol. 2008 May;26(5):252-8. doi: 10.1016/j.tibtech.2008.01.004. Review.

PMID:
18346803
20.

Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

Han S, Kim D.

PLoS Comput Biol. 2008 Aug 29;4(8):e1000162. doi: 10.1371/journal.pcbi.1000162.

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