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Items: 1 to 20 of 113

1.

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate.

Fan J, Zhang X, Li J, Jin H, Padakanti PK, Jones LA, Flores HP, Su Y, Perlmutter JS, Tu Z.

Bioorg Med Chem. 2014 May 1;22(9):2648-54. doi: 10.1016/j.bmc.2014.03.028.

2.

Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject.

Liu H, Jin H, Yue X, Zhang X, Yang H, Li J, Flores H, Su Y, Perlmutter JS, Tu Z.

Neuroimage. 2015 Nov 1;121:253-62. doi: 10.1016/j.neuroimage.2015.07.049.

3.

Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.

Li J, Zhang X, Jin H, Fan J, Flores H, Perlmutter JS, Tu Z.

J Med Chem. 2015 Nov 12;58(21):8584-600. doi: 10.1021/acs.jmedchem.5b01205.

4.

Synthesis and biological evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of PDE10A.

Ooms M, Celen S, Koole M, Langlois X, Schmidt M, De Angelis M, Andrés JI, Verbruggen A, Van Laere K, Bormans G.

Nucl Med Biol. 2014 Sep;41(8):695-704. doi: 10.1016/j.nucmedbio.2014.05.138.

PMID:
25002365
5.

Preclinical evaluation of [(18)F]JNJ42259152 as a PET tracer for PDE10A.

Celen S, Koole M, Ooms M, De Angelis M, Sannen I, Cornelis J, Alcazar J, Schmidt M, Verbruggen A, Langlois X, Van Laere K, Andrés JI, Bormans G.

Neuroimage. 2013 Nov 15;82:13-22. doi: 10.1016/j.neuroimage.2013.04.123.

PMID:
23664955
6.

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain.

Tu Z, Fan J, Li S, Jones LA, Cui J, Padakanti PK, Xu J, Zeng D, Shoghi KI, Perlmutter JS, Mach RH.

Bioorg Med Chem. 2011 Mar 1;19(5):1666-73. doi: 10.1016/j.bmc.2011.01.032.

7.

Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.

Kehler J, Kilburn JP, Estrada S, Christensen SR, Wall A, Thibblin A, Lubberink M, Bundgaard C, Brennum LT, Steiniger-Brach B, Christoffersen CT, Timmermann S, Kreilgaard M, Antoni G, Bang-Andersen B, Nielsen J.

J Nucl Med. 2014 Sep;55(9):1513-8. doi: 10.2967/jnumed.114.140178.

8.

Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain.

Celen S, Koole M, De Angelis M, Sannen I, Chitneni SK, Alcazar J, Dedeurwaerdere S, Moechars D, Schmidt M, Verbruggen A, Langlois X, Van Laere K, Andrés JI, Bormans G.

J Nucl Med. 2010 Oct;51(10):1584-91. doi: 10.2967/jnumed.110.077040.

9.

Phosphodiesterase 10A PET radioligand development program: from pig to human.

Plisson C, Weinzimmer D, Jakobsen S, Natesan S, Salinas C, Lin SF, Labaree D, Zheng MQ, Nabulsi N, Marques TR, Kapur S, Kawanishi E, Saijo T, Gunn RN, Carson RE, Rabiner EA.

J Nucl Med. 2014 Apr;55(4):595-601. doi: 10.2967/jnumed.113.131409.

10.

Development of a series of novel carbon-11 labeled PDE10A inhibitors.

Stepanov V, Miura S, Takano A, Amini N, Nakao R, Hasui T, Nakashima K, Taniguchi T, Kimura H, Kuroita T, Halldin C.

J Labelled Comp Radiopharm. 2015 May 15;58(5):202-8. doi: 10.1002/jlcr.3284.

PMID:
25891816
11.

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

Tu Z, Xu J, Jones LA, Li S, Mach RH.

Nucl Med Biol. 2010 May;37(4):509-16. doi: 10.1016/j.nucmedbio.2009.12.012.

12.

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

Padakanti PK, Zhang X, Jin H, Cui J, Wang R, Li J, Flores HP, Parsons SM, Perlmutter JS, Tu Z.

Mol Imaging Biol. 2014 Dec;16(6):773-80. doi: 10.1007/s11307-014-0749-9.

13.

Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates.

Hwang DR, Hu E, Allen JR, Davis C, Treanor J, Miller S, Chen H, Shi B, Narayanan TK, Barret O, Alagille D, Yu Z, Slifstein M.

Nucl Med Biol. 2015 Aug;42(8):654-63. doi: 10.1016/j.nucmedbio.2015.04.004.

PMID:
25935386
14.

Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.

Takano A, Stepanov V, Nakao R, Amini N, Gulyás B, Kimura H, Halldin C.

Synapse. 2016 Jun;70(6):253-63. doi: 10.1002/syn.21896.

PMID:
26878349
15.

Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.

Plisson C, Salinas C, Weinzimmer D, Labaree D, Lin SF, Ding YS, Jakobsen S, Smith PW, Eiji K, Carson RE, Gunn RN, Rabiner EA.

Nucl Med Biol. 2011 Aug;38(6):875-84. doi: 10.1016/j.nucmedbio.2011.02.005.

PMID:
21843784
16.

Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis.

Lin SF, Labaree D, Chen MK, Holden D, Gallezot JD, Kapinos M, Teng JK, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y.

Synapse. 2015 Feb;69(2):86-95. doi: 10.1002/syn.21792.

17.

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.

Tu Z, Zhang X, Jin H, Yue X, Padakanti PK, Yu L, Liu H, Flores HP, Kaneshige K, Parsons SM, Perlmutter JS.

Bioorg Med Chem. 2015 Aug 1;23(15):4699-709. doi: 10.1016/j.bmc.2015.05.058.

18.

Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography.

Takano A, Stepanov V, Gulyás B, Nakao R, Amini N, Miura S, Kimura H, Taniguchi T, Halldin C.

Synapse. 2015 Jul;69(7):345-55. doi: 10.1002/syn.21821.

PMID:
25892433
19.

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.

Harada A, Suzuki K, Miura S, Hasui T, Kamiguchi N, Ishii T, Taniguchi T, Kuroita T, Takano A, Stepanov V, Halldin C, Kimura H.

Nucl Med Biol. 2015 Feb;42(2):146-54. doi: 10.1016/j.nucmedbio.2014.09.005.

PMID:
25451212
20.

Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates.

Hwang DR, Hu E, Rumfelt S, Easwaramoorthy B, Castrillon J, Davis C, Allen JR, Chen H, Treanor J, Abi-Dargham A, Slifstein M.

Nucl Med Biol. 2014 Apr;41(4):343-9. doi: 10.1016/j.nucmedbio.2014.01.007.

PMID:
24607437
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