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Items: 1 to 20 of 172

1.

Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Li SZ, Zhang HH, Liang JB, Song Y, Jin BX, Xing NN, Fan GC, Du RL, Zhang XD.

Biochim Biophys Acta. 2014 Jul;1843(7):1365-72. doi: 10.1016/j.bbamcr.2014.03.028. Epub 2014 Apr 12.

2.

LATS2 inhibits the activity of NF-κ B signaling by disrupting the interaction between TAK1 and IKKβ.

Yao F, Zhou W, Zhong C, Fang W.

Tumour Biol. 2015 Sep;36(10):7873-9. doi: 10.1007/s13277-015-3362-x. Epub 2015 May 7.

PMID:
25946971
3.

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.

Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB.

J Mol Biol. 2003 Feb 7;326(1):105-15.

PMID:
12547194
4.

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.

Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA.

Mol Cell Biol. 2011 Jul;31(14):2774-86. doi: 10.1128/MCB.01139-10. Epub 2011 May 23.

5.

Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1.

Higashimoto T, Chan N, Lee YK, Zandi E.

J Biol Chem. 2008 Dec 19;283(51):35354-67. doi: 10.1074/jbc.M806258200. Epub 2008 Oct 27.

6.

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V.

Mol Cell. 2010 Oct 8;40(1):75-86. doi: 10.1016/j.molcel.2010.09.010.

7.

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.

Mei ZZ, Chen XY, Hu SW, Wang N, Ou XL, Wang J, Luo HH, Liu J, Jiang Y.

J Biol Chem. 2016 Aug 26;291(35):18176-89. doi: 10.1074/jbc.M116.715854. Epub 2016 Jul 7.

8.

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.

You DJ, Park CR, Furlong M, Koo O, Lee C, Ahn C, Seong JY, Hwang JI.

Cell Signal. 2015 Nov;27(11):2173-81. doi: 10.1016/j.cellsig.2015.08.012. Epub 2015 Aug 18.

PMID:
26296658
9.

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.

Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I.

J Biol Chem. 2003 Sep 19;278(38):36916-23. Epub 2003 Jul 3.

10.

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.

Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang RF, Cui J.

Sci Rep. 2015 Aug 4;5:12738. doi: 10.1038/srep12738.

11.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
12.

Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.

Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM.

PLoS One. 2012;7(5):e36601. doi: 10.1371/journal.pone.0036601. Epub 2012 May 8.

13.

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.

Kim JE, You DJ, Lee C, Ahn C, Seong JY, Hwang JI.

Cell Signal. 2010 Nov;22(11):1645-54. doi: 10.1016/j.cellsig.2010.06.004. Epub 2010 Jun 20.

PMID:
20600852
14.

NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.

Solt LA, Madge LA, May MJ.

J Biol Chem. 2009 Oct 2;284(40):27596-608. doi: 10.1074/jbc.M109.047563. Epub 2009 Aug 7.

15.

GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.

Kim YL, Kim JE, Shin KJ, Lee S, Ahn C, Chung J, Kim DH, Seong JY, Hwang JI.

Cell Signal. 2008 Nov;20(11):2127-33. doi: 10.1016/j.cellsig.2008.08.001. Epub 2008 Aug 9.

PMID:
18755269
16.

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.

Zhang J, Clark K, Lawrence T, Peggie MW, Cohen P.

Biochem J. 2014 Aug 1;461(3):531-7. doi: 10.1042/BJ20140444.

18.

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.

Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S25. doi: 10.1186/1471-2164-11-S4-S25.

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