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Items: 1 to 20 of 111

1.

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro.

Griggs AM, Agim ZS, Mishra VR, Tambe MA, Director-Myska AE, Turteltaub KW, McCabe GP, Rochet JC, Cannon JR.

Toxicol Sci. 2014 Jul;140(1):179-89. doi: 10.1093/toxsci/kfu060. Epub 2014 Apr 9. Erratum in: Toxicol Sci. 2014 Oct;141(2):560.

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4.

Biomonitoring of dietary heterocyclic amines and metabolites in urine by liquid phase microextraction: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a possible biomarker of exposure to dietary PhIP.

Busquets R, Frandsen H, Jönsson JÅ, Puignou L, Galceran MT, Skog K.

Chem Res Toxicol. 2013 Feb 18;26(2):233-40. doi: 10.1021/tx3003966. Epub 2013 Jan 15.

PMID:
23276304
5.

A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.

Gu D, McNaughton L, Lemaster D, Lake BG, Gooderham NJ, Kadlubar FF, Turesky RJ.

Chem Res Toxicol. 2010 Apr 19;23(4):788-801. doi: 10.1021/tx900436m.

6.

Mapping serum albumin adducts of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by data-dependent tandem mass spectrometry.

Peng L, Dasari S, Tabb DL, Turesky RJ.

Chem Res Toxicol. 2012 Oct 15;25(10):2179-93. doi: 10.1021/tx300253j. Epub 2012 Aug 14. Erratum in: Chem Res Toxicol. 2013 Feb 18;26(2):300.

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8.

MPP(+)-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress.

Hsieh YC, Mounsey RB, Teismann P.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Aug;384(2):157-67. doi: 10.1007/s00210-011-0660-8. Epub 2011 Jun 12.

10.

High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.

Bellocq D, Molina J, Rathahao E, Canlet C, Taché S, Martin PG, Pierre F, Paris A.

Mutat Res. 2008 May 31;653(1-2):34-43. doi: 10.1016/j.mrgentox.2008.02.010. Epub 2008 Mar 15.

PMID:
18434241
12.

Mass spectrometric characterization of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-oxidized metabolites bound at Cys34 of human serum albumin.

Peng L, Turesky RJ.

Chem Res Toxicol. 2011 Nov 21;24(11):2004-17. doi: 10.1021/tx2003504. Epub 2011 Oct 4.

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Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.

Xiang W, Schlachetzki JC, Helling S, Bussmann JC, Berlinghof M, Schäffer TE, Marcus K, Winkler J, Klucken J, Becker CM.

Mol Cell Neurosci. 2013 May;54:71-83. doi: 10.1016/j.mcn.2013.01.004. Epub 2013 Jan 28.

PMID:
23369945
17.

The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans.

Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill JP, Williams S, Nowell S, MacLeod S, Dingley KH, Turteltaub KW, Lang NP, Felton JS.

Carcinogenesis. 1999 Apr;20(4):705-13.

PMID:
10223203
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19.

Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups.

Davis CD, Ghoshal A, Schut HA, Snyderwine EG.

J Natl Cancer Inst. 1994 Jul 20;86(14):1065-70.

PMID:
8021955
20.

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.

Papaioannou MD, Koufaris C, Gooderham NJ.

Toxicol Lett. 2014 Aug 17;229(1):9-16. doi: 10.1016/j.toxlet.2014.05.021. Epub 2014 May 28.

PMID:
24877718

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