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Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.

Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.

PLoS One. 2014 Apr 8;9(4):e92290. doi: 10.1371/journal.pone.0092290. eCollection 2014.


Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.

Mukherjee R, Chakrabarti O.

J Cell Sci. 2016 Feb 15;129(4):757-73. doi: 10.1242/jcs.176537. Epub 2016 Jan 7.


Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis.

Lee JH, Han YS, Yoon YM, Yun CW, Yun SP, Kim SM, Kwon HY, Jeong D, Baek MJ, Lee HJ, Lee SJ, Han HJ, Lee SH.

Oncogene. 2017 Nov 23;36(47):6555-6567. doi: 10.1038/onc.2017.263. Epub 2017 Jul 31.


Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein response.

Apodaca J, Kim I, Rao H.

Biochem Biophys Res Commun. 2006 Aug 18;347(1):319-26. Epub 2006 Jun 21.


Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases.

Wang Y, Ha SW, Zhang T, Kho DH, Raz A, Xie Y.

Oncotarget. 2014 Apr 30;5(8):2044-51.


Peripheral endoplasmic reticulum localization of the Gp78 ubiquitin ligase activity.

St-Pierre P, Dang T, Joshi B, Nabi IR.

J Cell Sci. 2012 Apr 1;125(Pt 7):1727-37. doi: 10.1242/jcs.096396. Epub 2012 Feb 10.


Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.

Fu M, St-Pierre P, Shankar J, Wang PT, Joshi B, Nabi IR.

Mol Biol Cell. 2013 Apr;24(8):1153-62. doi: 10.1091/mbc.E12-08-0607. Epub 2013 Feb 20.


Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.

Choi K, Kim H, Kang H, Lee SY, Lee SJ, Back SH, Lee SH, Kim MS, Lee JE, Park JY, Kim J, Kim S, Song JH, Choi Y, Lee S, Lee HJ, Kim JH, Cho S.

FEBS J. 2014 Jul;281(13):3048-60. doi: 10.1111/febs.12841. Epub 2014 Jun 6.


Prion protein glycosylation is not required for strain-specific neurotropism.

Piro JR, Harris BT, Nishina K, Soto C, Morales R, Rees JR, Supattapone S.

J Virol. 2009 Jun;83(11):5321-8. doi: 10.1128/JVI.02502-08. Epub 2009 Mar 18.


Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein.

Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, Nishida N.

Sci Rep. 2014 Mar 28;4:4504. doi: 10.1038/srep04504.


Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration.

Lin Z, Zhao D, Yang L.

Acta Biochim Biophys Sin (Shanghai). 2013 Jun;45(6):477-84. doi: 10.1093/abbs/gmt020. Epub 2013 Feb 28. Review.


Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.

Asante EA, Linehan JM, Smidak M, Tomlinson A, Grimshaw A, Jeelani A, Jakubcova T, Hamdan S, Powell C, Brandner S, Wadsworth JD, Collinge J.

PLoS Pathog. 2013;9(9):e1003643. doi: 10.1371/journal.ppat.1003643. Epub 2013 Sep 26.


Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein.

Race B, Phillips K, Meade-White K, Striebel J, Chesebro B.

J Virol. 2015 Jun;89(11):6022-32. doi: 10.1128/JVI.00362-15. Epub 2015 Mar 25.


The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.

Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7. Epub 2001 Nov 27.


Evolving views in prion glycosylation: functional and pathological implications.

Ermonval M, Mouillet-Richard S, Codogno P, Kellermann O, Botti J.

Biochimie. 2003 Jan-Feb;85(1-2):33-45. Review.


Gerstmann-Sträussler-Scheinker disease and "anchorless prion protein" mice share prion conformational properties diverging from sporadic Creutzfeldt-Jakob disease.

Zanusso G, Fiorini M, Ferrari S, Meade-White K, Barbieri I, Brocchi E, Ghetti B, Monaco S.

J Biol Chem. 2014 Feb 21;289(8):4870-81. doi: 10.1074/jbc.M113.531335. Epub 2014 Jan 7.


Misfolded PrP and a novel mechanism of proteasome inhibition.

Andre R, Tabrizi SJ.

Prion. 2012 Jan-Mar;6(1):32-6. doi: 10.4161/pri.6.1.18272. Review.


The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome.

Jin T, Gu Y, Zanusso G, Sy M, Kumar A, Cohen M, Gambetti P, Singh N.

J Biol Chem. 2000 Dec 8;275(49):38699-704.


Identification of novel putative-binding proteins for cellular prion protein and a specific interaction with the STIP1 homology and U-Box-containing protein 1.

Gimenez AP, Richter LM, Atherino MC, Beirão BC, Fávaro C Jr, Costa MD, Zanata SM, Malnic B, Mercadante AF.

Prion. 2015;9(5):355-66. doi: 10.1080/19336896.2015.1075347. Epub 2015 Aug 3.

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