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Items: 1 to 20 of 184

1.

Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation.

Rowley SM, Kuriakose T, Dockery LM, Tran-Ngyuen T, Gingerich AD, Wei L, Watford WT.

J Biol Chem. 2014 May 30;289(22):15788-97. doi: 10.1074/jbc.M114.559344. Epub 2014 Apr 8.

2.

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.

López-Peláez M, Soria-Castro I, Boscá L, Fernández M, Alemany S.

Eur J Immunol. 2011 Jun;41(6):1733-41. doi: 10.1002/eji.201041101. Epub 2011 May 24.

3.

Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.

Eltayeb S, Berg AL, Lassmann H, Wallström E, Nilsson M, Olsson T, Ericsson-Dahlstrand A, Sunnemark D.

J Neuroinflammation. 2007 May 7;4:14.

4.

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.

Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN.

Cell. 2000 Dec 22;103(7):1071-83.

5.

CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.

Nansen A, Marker O, Bartholdy C, Thomsen AR.

Eur J Immunol. 2000 Jul;30(7):1797-806.

6.

The role of chemokines and their receptors in the rejection of pig islet tissue xenografts.

Solomon MF, Kuziel WA, Mann DA, Simeonovic CJ.

Xenotransplantation. 2003 Mar;10(2):164-77.

PMID:
12588649
7.

Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis.

Shahrara S, Amin MA, Woods JM, Haines GK, Koch AE.

Arthritis Rheum. 2003 Dec;48(12):3568-83.

8.

Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN.

EMBO J. 2002 Sep 16;21(18):4831-40.

9.

LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages.

Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T.

FEBS Lett. 2012 May 21;586(10):1540-6. doi: 10.1016/j.febslet.2012.04.018. Epub 2012 Apr 21.

10.

Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages.

Ceppo F, Berthou F, Jager J, Dumas K, Cormont M, Tanti JF.

Endocrinology. 2014 Mar;155(3):951-64. doi: 10.1210/en.2013-1815. Epub 2014 Jan 1.

PMID:
24424060
11.

The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system.

Siebert H, Sachse A, Kuziel WA, Maeda N, Brück W.

J Neuroimmunol. 2000 Oct 2;110(1-2):177-85.

PMID:
11024548
12.

Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.

Kuriakose T, Rada B, Watford WT.

J Biol Chem. 2014 Dec 26;289(52):36089-100. doi: 10.1074/jbc.M114.587121. Epub 2014 Nov 5.

13.

Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection.

Chandra AP, Ouyang L, Yi S, Wong JK, Ha H, Walters SN, Patel AT, Stokes R, Jardine M, Hawthorne WJ, O'Connell PJ.

Xenotransplantation. 2007 Jan;14(1):48-59.

PMID:
17214704
14.

The role of tumor progression locus 2 protein kinase in glial inflammatory response.

Hirschhorn J, Mohanty S, Bhat NR.

J Neurochem. 2014 Mar;128(6):919-26. doi: 10.1111/jnc.12522. Epub 2013 Nov 21.

15.

Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.

Li X, Acuff NV, Peeks AR, Kirkland R, Wyatt KD, Nagy T, Watford WT.

J Biol Chem. 2016 Aug 5;291(32):16802-15. doi: 10.1074/jbc.M116.718783. Epub 2016 Jun 3.

16.

Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.

Soria-Castro I, Krzyzanowska A, Pelaéz ML, Regadera J, Ferrer G, Montoliu L, Rodríguez-Ramos R, Fernández M, Alemany S.

J Biol Chem. 2010 Oct 29;285(44):33805-15. doi: 10.1074/jbc.M110.169409. Epub 2010 Aug 24.

17.

Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue.

Reichel CA, Khandoga A, Anders HJ, Schlöndorff D, Luckow B, Krombach F.

J Leukoc Biol. 2006 Jan;79(1):114-22. Epub 2005 Nov 7.

PMID:
16275892
18.

Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation.

Bandow K, Maeda A, Kakimoto K, Kusuyama J, Shamoto M, Ohnishi T, Matsuguchi T.

Biochem Biophys Res Commun. 2010 Nov 26;402(4):755-61. doi: 10.1016/j.bbrc.2010.10.103. Epub 2010 Oct 29.

PMID:
21036155
19.

Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.

Sanz-Garcia C, Ferrer-Mayorga G, González-Rodríguez Á, Valverde AM, Martín-Duce A, Velasco-Martín JP, Regadera J, Fernández M, Alemany S.

J Biol Chem. 2013 May 24;288(21):15342-51. doi: 10.1074/jbc.M112.439547. Epub 2013 Apr 9.

20.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.

Sci Signal. 2017 Apr 18;10(475). pii: eaah4273. doi: 10.1126/scisignal.aah4273.

PMID:
28420753

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