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Items: 1 to 20 of 111

1.

BMP pathway regulation of and by macrophages.

Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K.

PLoS One. 2014 Apr 8;9(4):e94119. doi: 10.1371/journal.pone.0094119. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101543.

2.

Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.

Hagen M, Fagan K, Steudel W, Carr M, Lane K, Rodman DM, West J.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1473-9. Epub 2007 Feb 23.

PMID:
17322283
3.

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.

Maruyama H, Dewachter C, Belhaj A, Rondelet B, Sakai S, Remmelink M, Vachiery JL, Naeije R, Dewachter L.

J Heart Lung Transplant. 2015 Mar;34(3):468-78. doi: 10.1016/j.healun.2014.09.011. Epub 2014 Sep 28.

PMID:
25447587
4.

Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.

Tada Y, Majka S, Carr M, Harral J, Crona D, Kuriyama T, West J.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1556-63. Epub 2007 Mar 16.

PMID:
17369292
5.

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

6.

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M.

J Clin Invest. 2008 May;118(5):1846-57. doi: 10.1172/JCI32503.

7.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
8.

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

Upton PD, Davies RJ, Tajsic T, Morrell NW.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1135-45. doi: 10.1165/rcmb.2012-0470OC.

9.

Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.

Ihida-Stansbury K, McKean DM, Lane KB, Loyd JE, Wheeler LA, Morrell NW, Jones PL.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L694-702. Epub 2006 Jun 16.

PMID:
16782755
10.

Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.

Tojais NF, Cao A, Lai YJ, Wang L, Chen PI, Alcazar MAA, de Jesus Perez VA, Hopper RK, Rhodes CJ, Bill MA, Sakai LY, Rabinovitch M.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-1569. doi: 10.1161/ATVBAHA.117.309696. Epub 2017 Jun 15.

PMID:
28619995
11.

Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.

Leyton PA, Beppu H, Pappas A, Martyn TM, Derwall M, Baron DM, Galdos R, Bloch DB, Bloch KD.

PLoS One. 2013 Oct 8;8(10):e76947. doi: 10.1371/journal.pone.0076947. eCollection 2013.

12.

Physiologic and molecular consequences of endothelial Bmpr2 mutation.

Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J.

Respir Res. 2011 Jun 22;12:84. doi: 10.1186/1465-9921-12-84.

13.

Trapping of BMP receptors in distinct membrane domains inhibits their function in pulmonary arterial hypertension.

Jiang Y, Nohe A, Bragdon B, Tian C, Rudarakanchana N, Morrell NW, Petersen NO.

Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L218-27. doi: 10.1152/ajplung.00300.2010. Epub 2011 May 27.

PMID:
21622843
14.

Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.

Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G.

J Biol Chem. 2012 Aug 10;287(33):28067-77. doi: 10.1074/jbc.M112.379487. Epub 2012 Jun 20.

15.

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW.

Circ Res. 2005 May 27;96(10):1053-63. Epub 2005 Apr 21.

16.

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.

Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8. doi: 10.1164/rccm.201106-1130OC. Epub 2011 Sep 15.

17.

Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.

Drake KM, Dunmore BJ, McNelly LN, Morrell NW, Aldred MA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):403-9. doi: 10.1165/rcmb.2013-0100OC.

18.
19.

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions.

West J, Harral J, Lane K, Deng Y, Ickes B, Crona D, Albu S, Stewart D, Fagan K.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55. doi: 10.1152/ajplung.90255.2008. Epub 2008 Aug 22.

20.

Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.

Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW.

Circ Res. 2006 Mar 31;98(6):818-27. Epub 2006 Feb 23.

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