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Items: 1 to 20 of 108

1.

Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.

Zachos NC, Alamelumangpuram B, Lee LJ, Wang P, Kovbasnjuk O.

Cell Physiol Biochem. 2014;33(3):869-81. doi: 10.1159/000358659. Epub 2014 Mar 28.

2.

Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3.

Li X, Galli T, Leu S, Wade JB, Weinman EJ, Leung G, Cheong A, Louvard D, Donowitz M.

J Physiol. 2001 Dec 1;537(Pt 2):537-52.

3.

Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent.

Murtazina R, Kovbasnjuk O, Donowitz M, Li X.

J Biol Chem. 2006 Jun 30;281(26):17845-55. Epub 2006 Apr 27.

4.

Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.

Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U.

Cell Physiol Biochem. 2013;32(5):1386-402.

5.

The epithelial Na(+)/H(+) exchanger, NHE3, is internalized through a clathrin-mediated pathway.

Chow CW, Khurana S, Woodside M, Grinstein S, Orlowski J.

J Biol Chem. 1999 Dec 31;274(53):37551-8.

6.

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.

Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C266-75. doi: 10.1152/ajpcell.00277.2012. Epub 2013 May 22.

7.

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.

Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M.

Mol Biol Cell. 2017 Jul 1;28(13):1754-1767. doi: 10.1091/mbc.E16-12-0862. Epub 2017 May 11.

9.

GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA.

Chen H, Gao Z, He C, Xiang R, van Kuppevelt TH, Belting M, Zhang S.

Exp Cell Res. 2016 May 1;343(2):223-236. doi: 10.1016/j.yexcr.2016.04.009. Epub 2016 Apr 22.

PMID:
27090015
10.

Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin.

Musch MW, Arvans DL, Walsh-Reitz MM, Uchiyama K, Fukuda M, Chang EB.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1549-58. Epub 2007 Feb 15.

11.

Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation.

Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M.

Gastroenterology. 2004 Jan;126(1):122-35.

PMID:
14699494
12.

Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.

Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M.

J Cell Sci. 2014 Aug 15;127(Pt 16):3535-45. doi: 10.1242/jcs.149930. Epub 2014 Jun 13.

13.

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C771-82. doi: 10.1152/ajpcell.00119.2010. Epub 2010 Dec 29.

14.

Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells.

Sarnataro D, Caputo A, Casanova P, Puri C, Paladino S, Tivodar SS, Campana V, Tacchetti C, Zurzolo C.

PLoS One. 2009 Jun 8;4(6):e5829. doi: 10.1371/journal.pone.0005829.

15.

Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3.

Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X.

Mol Biol Cell. 2008 Sep;19(9):3859-70. doi: 10.1091/mbc.E08-01-0019. Epub 2008 Jul 9.

16.

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M.

Cell Physiol Biochem. 2008;22(5-6):693-704. doi: 10.1159/000185553. Epub 2008 Dec 9.

17.

Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).

Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, Cha B, Hubbard A, Donowitz M, Guggino SE.

J Biol Chem. 2011 Jul 1;286(26):22833-45. doi: 10.1074/jbc.M111.224998. Epub 2011 May 11.

18.

Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation.

Hu MC, Fan L, Crowder LA, Karim-Jimenez Z, Murer H, Moe OW.

J Biol Chem. 2001 Jul 20;276(29):26906-15. Epub 2001 Apr 27.

19.

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.

Pelaseyed T, Gustafsson JK, Gustafsson IJ, Ermund A, Hansson GC.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C457-67. doi: 10.1152/ajpcell.00141.2013. Epub 2013 Jun 19.

20.

Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent.

Li X, Zhang H, Cheong A, Leu S, Chen Y, Elowsky CG, Donowitz M.

J Physiol. 2004 May 1;556(Pt 3):791-804. Epub 2004 Feb 20.

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