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Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.

Kyriazis GA, Smith KR, Tyrberg B, Hussain T, Pratley RE.

Endocrinology. 2014 Jun;155(6):2112-21. doi: 10.1210/en.2013-2015. Epub 2014 Apr 8.


Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S.

Nat Med. 2015 Feb;21(2):173-7. doi: 10.1038/nm.3779. Epub 2015 Jan 12.


Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.

Kobayashi M, Ohnishi H, Okazawa H, Murata Y, Hayashi Y, Kobayashi H, Kitamura T, Matozaki T.

Endocrinology. 2008 Nov;149(11):5662-9. doi: 10.1210/en.2008-0236. Epub 2008 Jul 17.


Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.

Feng R, Qian C, Liu Q, Jin Y, Liu L, Li S, Liao Y, Zhou H, Liu W, Rayner CK, Ma J.

Gen Comp Endocrinol. 2017 Oct 1;252:142-149. doi: 10.1016/j.ygcen.2017.08.008. Epub 2017 Aug 4.


Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.

Wang N, Guo DY, Tian X, Lin HP, Li YP, Chen SJ, Fu YC, Xu WC, Wei CJ.

Gen Comp Endocrinol. 2016 Oct 1;237:98-108. doi: 10.1016/j.ygcen.2016.08.011. Epub 2016 Aug 26.


TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.

Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, Momose Y, Takeuchi K.

J Pharmacol Exp Ther. 2011 Oct;339(1):228-37. doi: 10.1124/jpet.111.183772. Epub 2011 Jul 13.


Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.

Kyriazis GA, Soundarapandian MM, Tyrberg B.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32. doi: 10.1073/pnas.1115183109. Epub 2012 Feb 6.


Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes.

Young RL, Chia B, Isaacs NJ, Ma J, Khoo J, Wu T, Horowitz M, Rayner CK.

Diabetes. 2013 Oct;62(10):3532-41. doi: 10.2337/db13-0581. Epub 2013 Jun 12.


Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes.

Do OH, Gunton JE, Gaisano HY, Thorn P.

Diabetologia. 2016 Jun;59(6):1222-30. doi: 10.1007/s00125-016-3942-3. Epub 2016 Apr 5.


Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes.

Chan JY, Luzuriaga J, Bensellam M, Biden TJ, Laybutt DR.

Diabetes. 2013 May;62(5):1557-68. doi: 10.2337/db12-0701. Epub 2012 Dec 28.


The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.

Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H.

Cell Metab. 2005 Apr;1(4):245-58.


Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function.

Dunér P, Al-Amily IM, Soni A, Asplund O, Safi F, Storm P, Groop L, Amisten S, Salehi A.

J Clin Endocrinol Metab. 2016 Dec;101(12):4637-4645. Epub 2016 Sep 16.


The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice.

Zhang Y, Xie Z, Zhou L, Li L, Zhang H, Zhou G, Ma X, Herrera PL, Liu Z, Grusby MJ, Zhang WJ.

Gastroenterology. 2012 Jun;142(7):1571-1580.e6. doi: 10.1053/j.gastro.2012.02.043. Epub 2012 Feb 25.


Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells.

Kojima I, Nakagawa Y, Hamano K, Medina J, Li L, Nagasawa M.

Biol Pharm Bull. 2015;38(5):674-9. doi: 10.1248/bpb.b14-00895.


Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states.

Medina A, Nakagawa Y, Ma J, Li L, Hamano K, Akimoto T, Ninomiya Y, Kojima I.

Endocr J. 2014;61(8):797-805. Epub 2014 Jun 5.


Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH.

PLoS One. 2013;8(3):e58655. doi: 10.1371/journal.pone.0058655. Epub 2013 Mar 13.


Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.


GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.

Veprik A, Laufer D, Weiss S, Rubins N, Walker MD.

FASEB J. 2016 Nov;30(11):3860-3869. Epub 2016 Aug 22.


Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes.

Han D, Yamamoto Y, Munesue S, Motoyoshi S, Saito H, Win MT, Watanabe T, Tsuneyama K, Yamamoto H.

Genes Cells. 2013 Apr;18(4):302-14. doi: 10.1111/gtc.12036. Epub 2013 Feb 14.


Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion.

Locke JM, da Silva Xavier G, Dawe HR, Rutter GA, Harries LW.

Diabetologia. 2014 Jan;57(1):122-8. doi: 10.1007/s00125-013-3089-4. Epub 2013 Oct 23.

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