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Items: 1 to 20 of 86

1.

Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'.

Wu Y, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, Cai X.

Biochem J. 2014 Jun 15;460(3):343-52. doi: 10.1042/BJ20140089.

PMID:
24712709
2.

Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin.

Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, Wu Y.

Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8241-50. doi: 10.1167/iovs.14-15709.

PMID:
25414195
3.

Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy.

Conley SM, Cai X, Makkia R, Wu Y, Sparrow JR, Naash MI.

Biochim Biophys Acta. 2012 Jul;1822(7):1169-79. doi: 10.1016/j.bbadis.2011.10.007. Epub 2011 Oct 13.

4.

A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine.

Yamamoto K, Yoon KD, Ueda K, Hashimoto M, Sparrow JR.

Invest Ophthalmol Vis Sci. 2011 Nov 25;52(12):9084-90. doi: 10.1167/iovs.11-8632.

5.

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4742-7. Epub 2003 Apr 1.

6.

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.

Maeda A, Golczak M, Maeda T, Palczewski K.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5435-43. doi: 10.1167/iovs.09-3944. Epub 2009 Jun 24.

7.

Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells.

Li J, Yao K, Yu X, Dong X, Gan L, Luo C, Wu Y.

J Biol Chem. 2013 Dec 13;288(50):35671-82. doi: 10.1074/jbc.M113.511386. Epub 2013 Oct 29.

8.

Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.

Charbel Issa P, Barnard AR, Singh MS, Carter E, Jiang Z, Radu RA, Schraermeyer U, MacLaren RE.

Invest Ophthalmol Vis Sci. 2013 Aug 19;54(8):5602-12. doi: 10.1167/iovs.13-11688.

9.

Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.

Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL.

Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4393-401. Erratum in: Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3735.

PMID:
16303925
10.

Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease.

Wu Y, Fishkin NE, Pande A, Pande J, Sparrow JR.

J Biol Chem. 2009 Jul 24;284(30):20155-66. doi: 10.1074/jbc.M109.021345. Epub 2009 May 28.

11.
12.

Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH.

Novartis Found Symp. 2004;255:51-63; discussion 63-7, 177-8.

PMID:
14750596
13.

A2E, a byproduct of the visual cycle.

Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanishi K.

Vision Res. 2003 Dec;43(28):2983-90. Review.

14.

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

Kim SR, Jang YP, Jockusch S, Fishkin NE, Turro NJ, Sparrow JR.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19273-8. Epub 2007 Nov 28.

15.

Observation of A2E oxidation products in human retinal lipofuscin.

Avalle LB, Wang Z, Dillon JP, Gaillard ER.

Exp Eye Res. 2004 Apr;78(4):895-8.

PMID:
15037123
16.

Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition.

Zhou J, Ueda K, Zhao J, Sparrow JR.

J Biol Chem. 2015 Nov 6;290(45):27215-27. doi: 10.1074/jbc.M115.680363. Epub 2015 Sep 22.

17.

Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies.

Bui TV, Han Y, Radu RA, Travis GH, Mata NL.

J Biol Chem. 2006 Jun 30;281(26):18112-9. Epub 2006 Apr 25.

18.

Bisretinoids of RPE lipofuscin: trigger for complement activation in age-related macular degeneration.

Sparrow JR.

Adv Exp Med Biol. 2010;703:63-74. doi: 10.1007/978-1-4419-5635-4_5. Review.

PMID:
20711707
19.

Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance.

Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, Palczewski K.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4917-25. doi: 10.1167/iovs.09-3581. Epub 2009 Jun 3.

20.

Spatial localization of A2E in the retinal pigment epithelium.

Grey AC, Crouch RK, Koutalos Y, Schey KL, Ablonczy Z.

Invest Ophthalmol Vis Sci. 2011 Jun 6;52(7):3926-33. doi: 10.1167/iovs.10-7020.

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