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Items: 1 to 20 of 141

1.

Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.

Yamanaka T, Wong HK, Tosaki A, Bauer PO, Wada K, Kurosawa M, Shimogori T, Hattori N, Nukina N.

PLoS One. 2014 Apr 4;9(4):e93891. doi: 10.1371/journal.pone.0093891. eCollection 2014.

2.

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.

Lejeune FX, Mesrob L, Parmentier F, Bicep C, Vazquez-Manrique RP, Parker JA, Vert JP, Tourette C, Neri C.

BMC Genomics. 2012 Mar 13;13:91. doi: 10.1186/1471-2164-13-91.

3.

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

Zhang S, Binari R, Zhou R, Perrimon N.

Genetics. 2010 Apr;184(4):1165-79. doi: 10.1534/genetics.109.112516. Epub 2010 Jan 25.

4.

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N.

J Biol Chem. 2009 May 8;284(19):13153-64. doi: 10.1074/jbc.M809229200. Epub 2009 Mar 11.

5.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

6.

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

Schulte J, Sepp KJ, Wu C, Hong P, Littleton JT.

PLoS One. 2011;6(8):e23841. doi: 10.1371/journal.pone.0023841. Epub 2011 Aug 31.

7.

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia.

Tower C, Fu L, Gill R, Prichard M, Lesort M, Sztul E.

Neurobiol Dis. 2011 Jan;41(1):11-22. doi: 10.1016/j.nbd.2010.08.013. Epub 2010 Aug 20.

8.

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

Somat Cell Mol Genet. 1998 Jul;24(4):217-33.

PMID:
10410676
9.

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.

Godin JD, Poizat G, Hickey MA, Maschat F, Humbert S.

EMBO J. 2010 Jul 21;29(14):2433-45. doi: 10.1038/emboj.2010.117. Epub 2010 Jun 8.

10.

Arfaptin 2 regulates the aggregation of mutant huntingtin protein.

Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C.

Nat Cell Biol. 2002 Mar;4(3):240-5.

PMID:
11854752
11.

Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.

Weiss KR, Kimura Y, Lee WC, Littleton JT.

Genetics. 2012 Feb;190(2):581-600. doi: 10.1534/genetics.111.133710. Epub 2011 Nov 17.

12.

Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation.

Bauer PO, Hudec R, Ozaki S, Okuno M, Ebisui E, Mikoshiba K, Nukina N.

Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):13-7. doi: 10.1016/j.bbrc.2011.10.096. Epub 2011 Oct 28.

PMID:
22056561
13.
14.

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.

Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L.

Exp Cell Res. 2008 Mar 10;314(5):950-60. doi: 10.1016/j.yexcr.2007.12.025. Epub 2008 Jan 14.

PMID:
18255062
16.

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.

Hum Mol Genet. 2012 Jan 1;21(1):101-14. doi: 10.1093/hmg/ddr445. Epub 2011 Sep 27.

PMID:
21954231
17.

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.

Trepte P, Strempel N, Wanker EE.

Essays Biochem. 2014;56:167-80. doi: 10.1042/bse0560167. Review.

PMID:
25131594
18.

Protein aggregation and neurodegeneration: clues from a yeast model of Huntington's disease.

Bocharova N, Chave-Cox R, Sokolov S, Knorre D, Severin F.

Biochemistry (Mosc). 2009 Feb;74(2):231-4.

19.

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death.

Choi YJ, Kim SI, Lee JW, Kwon YS, Lee HJ, Kim SS, Chun W.

Mol Cell Neurosci. 2012 Feb;49(2):127-37. doi: 10.1016/j.mcn.2011.11.003. Epub 2011 Nov 20.

PMID:
22122824
20.

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease.

Hands SL, Mason R, Sajjad MU, Giorgini F, Wyttenbach A.

Biochem Soc Trans. 2010 Apr;38(2):552-8. doi: 10.1042/BST0380552.

PMID:
20298220

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