Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99

1.

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.

Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD.

Nat Immunol. 2014 May;15(5):457-64. doi: 10.1038/ni.2867. Epub 2014 Apr 6.

2.

SGK1: master and commander of the fate of helper T cells.

Norton M, Screaton RA.

Nat Immunol. 2014 May;15(5):411-3. doi: 10.1038/ni.2875. No abstract available.

PMID:
24747705
3.

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

García-Martínez JM, Alessi DR.

Biochem J. 2008 Dec 15;416(3):375-85. doi: 10.1042/BJ20081668.

PMID:
18925875
4.

mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.

Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D.

J Clin Invest. 2015 Jan;125(1):117-28. doi: 10.1172/JCI73935. Epub 2014 Nov 21.

5.

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.

Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V.

J Biol Chem. 2011 Oct 28;286(43):37830-40. doi: 10.1074/jbc.M111.293233. Epub 2011 Sep 7.

6.

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.

Andersen MN, Krzystanek K, Petersen F, Bomholtz SH, Olesen SP, Abriel H, Jespersen T, Rasmussen HB.

J Biol Chem. 2013 Dec 27;288(52):36841-54. doi: 10.1074/jbc.M113.525931. Epub 2013 Nov 8.

7.

mTORC2 is the hydrophobic motif kinase for SGK1.

Yan L, Mieulet V, Lamb RF.

Biochem J. 2008 Dec 15;416(3):e19-21. doi: 10.1042/BJ20082202.

PMID:
19025518
8.

Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway.

He J, Qi D, Wang DX, Deng W, Ye Y, Feng LH, Zhu T, Zhao Y, Zhang CR.

Exp Cell Res. 2015 Feb 1;331(1):164-75. doi: 10.1016/j.yexcr.2014.09.024. Epub 2014 Sep 28.

PMID:
25265063
9.

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O.

J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18.

10.

Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.

Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D.

J Biol Chem. 2012 Sep 21;287(39):33014-25. Epub 2012 Jul 31.

11.

Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation.

Salker MS, Steel JH, Hosseinzadeh Z, Nautiyal J, Webster Z, Singh Y, Brucker S, Lang F, Brosens JJ.

Cell Physiol Biochem. 2016;39(5):2077-2087. Epub 2016 Oct 31.

12.

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D.

Mol Endocrinol. 2005 Dec;19(12):3073-84. Epub 2005 Aug 11.

PMID:
16099816
13.

mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.

Lu M, Wang J, Ives HE, Pearce D.

J Biol Chem. 2011 Sep 2;286(35):30647-54. doi: 10.1074/jbc.M111.257592. Epub 2011 Jul 11.

14.

Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.

Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Náray-Fejes-Tóth A, Staub O.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F977-85. doi: 10.1152/ajprenal.00535.2011. Epub 2012 Feb 1.

15.

Expression of ENaC, SGK1 and Nedd4 isoforms in the cochlea of guinea pig.

Zhong SX, Hu GH, Liu ZH.

Folia Histochem Cytobiol. 2014;52(2):144-8. doi: 10.5603/FHC.2014.0010.

16.

Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.

Lang F, Pearce D.

Nephrol Dial Transplant. 2016 Feb;31(2):200-5. doi: 10.1093/ndt/gfv270. Epub 2015 Jul 9. Review.

PMID:
26163195
17.

Regulation of a third conserved phosphorylation site in SGK1.

Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH.

J Biol Chem. 2009 Feb 6;284(6):3453-60. doi: 10.1074/jbc.M807502200. Epub 2008 Dec 9.

18.

The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.

Lamothe SM, Zhang S.

J Biol Chem. 2013 May 24;288(21):15075-84. doi: 10.1074/jbc.M113.453670. Epub 2013 Apr 15.

19.

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W.

Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016.

20.

mTOR complex-2 activates ENaC by phosphorylating SGK1.

Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D.

J Am Soc Nephrol. 2010 May;21(5):811-8. doi: 10.1681/ASN.2009111168. Epub 2010 Mar 25.

Supplemental Content

Support Center