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Items: 1 to 20 of 77


uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells.

Alapati K, Kesanakurti D, Rao JS, Dasari VR.

Stem Cell Res. 2014 May;12(3):716-29. doi: 10.1016/j.scr.2014.02.008. Epub 2014 Mar 12.


MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.

Veeravalli KK, Chetty C, Ponnala S, Gondi CS, Lakka SS, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Jul 15;5(7):e11583. doi: 10.1371/journal.pone.0011583.


Knockdown of cathepsin B and uPAR inhibits CD151 and α3β1 integrin-mediated cell adhesion and invasion in glioma.

Rao Malla R, Gopinath S, Alapati K, Gorantla B, Gondi CS, Rao JS.

Mol Carcinog. 2013 Oct;52(10):777-90. doi: 10.1002/mc.21915. Epub 2012 Apr 11.


uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells.

Alapati K, Gopinath S, Malla RR, Dasari VR, Rao JS.

Int J Oncol. 2012 Aug;41(2):599-610. doi: 10.3892/ijo.2012.1496. Epub 2012 May 24.


uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells.

Malla RR, Gopinath S, Alapati K, Gorantla B, Gondi CS, Rao JS.

Neuro Oncol. 2012 Jun;14(6):745-60. doi: 10.1093/neuonc/nos088. Epub 2012 May 9.


Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression.

Gopinath S, Malla R, Alapati K, Gorantla B, Gujrati M, Dinh DH, Rao JS.

Carcinogenesis. 2013 Mar;34(3):550-9. doi: 10.1093/carcin/bgs375. Epub 2012 Dec 7.


Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.

Gopinath S, Malla RR, Gondi CS, Alapati K, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

PLoS One. 2010 Jul 22;5(7):e11668. doi: 10.1371/journal.pone.0011668.


Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.

Gopinath S, Alapati K, Malla RR, Gondi CS, Mohanam S, Dinh DH, Rao JS.

Mol Oncol. 2011 Oct;5(5):426-37. doi: 10.1016/j.molonc.2011.07.004. Epub 2011 Jul 26.


uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.

Gupta R, Nalla AK, Gogineni VR, Chetty C, Bhoopathi P, Klopfenstein JD, Tsung AJ, Mohanam S, Rao JS.

PLoS One. 2011 Feb 11;6(2):e17123. doi: 10.1371/journal.pone.0017123.


Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo.

Gupta R, Rao Gogineni V, Nalla AK, Chetty C, Klopfenstein JD, Tsung AJ, Mohanam S, Rao JS.

Int J Oncol. 2011 Apr;38(4):973-83. doi: 10.3892/ijo.2011.934. Epub 2011 Feb 2.


uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma.

Malla RR, Gopinath S, Gondi CS, Alapati K, Dinh DH, Tsung AJ, Rao JS.

J Neurooncol. 2012 Mar;107(1):69-80. doi: 10.1007/s11060-011-0727-x. Epub 2011 Oct 2.


Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.

Malla R, Gopinath S, Alapati K, Gondi CS, Gujrati M, Dinh DH, Mohanam S, Rao JS.

PLoS One. 2010 Oct 29;5(10):e13731. doi: 10.1371/journal.pone.0013731.


Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration.

Zhuang T, Chelluboina B, Ponnala S, Velpula KK, Rehman AA, Chetty C, Zakharian E, Rao JS, Veeravalli KK.

BMC Cancer. 2013 Dec 11;13:590. doi: 10.1186/1471-2407-13-590.


Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma.

Malla RR, Gopinath S, Gondi CS, Alapati K, Dinh DH, Gujrati M, Rao JS.

Cancer Gene Ther. 2011 Jun;18(6):419-34. doi: 10.1038/cgt.2011.9. Epub 2011 Mar 11.


Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway.

Veeravalli KK, Ponnala S, Chetty C, Tsung AJ, Gujrati M, Rao JS.

Cell Signal. 2012 Jan;24(1):272-81. doi: 10.1016/j.cellsig.2011.09.011. Epub 2011 Sep 17.


uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway.

Gogineni VR, Gupta R, Nalla AK, Velpula KK, Rao JS.

Cell Death Dis. 2012 Dec 6;3:e439. doi: 10.1038/cddis.2012.170.


Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.

Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS.

Cancer Res. 2004 Jun 15;64(12):4069-77.


Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.

Liu X, Qiu F, Liu Z, Lan Y, Wang K, Zhou PK, Wang Y, Hua ZC.

Apoptosis. 2014 Oct;19(10):1532-44. doi: 10.1007/s10495-014-1025-9.


Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.

Ponnala S, Chetty C, Veeravalli KK, Dinh DH, Klopfenstein JD, Rao JS.

Int J Oncol. 2012 Feb;40(2):509-18. doi: 10.3892/ijo.2011.1255. Epub 2011 Nov 7.

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