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Items: 1 to 20 of 69

1.

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.

Vielnascher RM, Hainzl E, Leitner NR, Rammerstorfer M, Popp D, Witalisz A, Rom R, Karaghiosoff M, Kolbe T, Müller S, Rülicke T, Lassnig C, Strobl B, Müller M.

Transgenic Res. 2014 Jun;23(3):519-29. doi: 10.1007/s11248-014-9795-y. Epub 2014 Apr 3.

PMID:
24696087
2.

Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance.

Simma O, Zebedin E, Neugebauer N, Schellack C, Pilz A, Chang-Rodriguez S, Lingnau K, Weisz E, Putz EM, Pickl WF, Felzmann T, Müller M, Decker T, Sexl V, Stoiber D.

Cancer Res. 2009 Jan 1;69(1):203-11. doi: 10.1158/0008-5472.CAN-08-1705.

3.

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.

Hashiguchi T, Oyamada A, Sakuraba K, Shimoda K, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H.

J Immunol. 2014 May 15;192(10):4739-47. doi: 10.4049/jimmunol.1303067. Epub 2014 Apr 11.

4.

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.

Nakamura R, Shibata K, Yamada H, Shimoda K, Nakayama K, Yoshikai Y.

J Immunol. 2008 Aug 1;181(3):2071-5.

5.

Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.

Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Müller M.

J Immunol. 2005 Sep 15;175(6):4000-8.

6.

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection.

Li W, Yamada H, Yajima T, Nakagawa R, Shimoda K, Nakayama K, Yoshikai Y.

J Immunol. 2007 Apr 1;178(7):4482-8.

7.

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.

Fuchs S, Kaiser-Labusch P, Bank J, Ammann S, Kolb-Kokocinski A, Edelbusch C, Omran H, Ehl S.

Eur J Immunol. 2016 Nov;46(11):2639-2649. doi: 10.1002/eji.201646519. Epub 2016 Oct 5.

PMID:
27615517
8.

Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.

Potla R, Koeck T, Wegrzyn J, Cherukuri S, Shimoda K, Baker DP, Wolfman J, Planchon SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, Larner AC.

Mol Cell Biol. 2006 Nov;26(22):8562-71. Epub 2006 Sep 18.

9.

An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.

Aizu K, Li W, Yajima T, Arai T, Shimoda K, Nimura Y, Yoshikai Y.

Eur J Immunol. 2006 Nov;36(11):3060-70.

10.

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.

Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.

Immunity. 2006 Nov;25(5):745-55.

11.

Partial impairment of cytokine responses in Tyk2-deficient mice.

Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Müller M.

Immunity. 2000 Oct;13(4):549-60.

12.

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, Shibata S, Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K.

Immunity. 2000 Oct;13(4):561-71.

13.

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.

Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H.

J Immunol. 2009 Dec 1;183(11):7539-46. doi: 10.4049/jimmunol.0902740. Epub 2009 Nov 16.

14.

The Atlantic salmon protein tyrosine kinase Tyk2: molecular cloning, modulation of expression and function.

Sobhkhez M, Hansen T, Iliev DB, Skjesol A, Jørgensen JB.

Dev Comp Immunol. 2013 Dec;41(4):553-63. doi: 10.1016/j.dci.2013.07.008. Epub 2013 Jul 18.

PMID:
23872231
15.

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.

Shimoda K, Tsutsui H, Aoki K, Kato K, Matsuda T, Numata A, Takase K, Yamamoto T, Nukina H, Hoshino T, Asano Y, Gondo H, Okamura T, Okamura S, Nakayama K, Nakanishi K, Niho Y, Harada M.

Blood. 2002 Mar 15;99(6):2094-9.

16.

Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice.

Hosogi M, Tonogaito H, Aioi A, Hamada K, Shimoda K, Muromoto R, Matsuda T, Miyachi Y.

J Dermatol Sci. 2004 Oct;36(1):51-6.

PMID:
15488705
17.

Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.

Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, Saito Y, Shimoda K, Iwamoto I, Nakajima H.

Blood. 2007 Jul 15;110(2):553-60. Epub 2007 Mar 29.

18.

Tyk2 is a therapeutic target for psoriasis-like skin inflammation.

Ishizaki M, Muromoto R, Akimoto T, Sekine Y, Kon S, Diwan M, Maeda H, Togi S, Shimoda K, Oritani K, Matsuda T.

Int Immunol. 2014 May;26(5):257-67. doi: 10.1093/intimm/dxt062. Epub 2013 Dec 17.

PMID:
24345760
19.

Control of Leishmania major in the absence of Tyk2 kinase.

Schleicher U, Mattner J, Blos M, Schindler H, Röllinghoff M, Karaghiosoff M, Müller M, Werner-Felmayer G, Bogdan C.

Eur J Immunol. 2004 Feb;34(2):519-29.

20.

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