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Items: 1 to 20 of 99

1.

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.

Bomer N, den Hollander W, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I.

Ann Rheum Dis. 2015 Aug;74(8):1571-9. doi: 10.1136/annrheumdis-2013-204739. Epub 2014 Apr 2.

2.

Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.

Bos SD, Bovée JV, Duijnisveld BJ, Raine EV, van Dalen WJ, Ramos YF, van der Breggen R, Nelissen RG, Slagboom PE, Loughlin J, Meulenbelt I.

Ann Rheum Dis. 2012 Jul;71(7):1254-8. doi: 10.1136/annrheumdis-2011-200981. Epub 2012 Apr 4.

PMID:
22492780
3.

Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats.

Nagase H, Nagasawa Y, Tachida Y, Sakakibara S, Okutsu J, Suematsu N, Arita S, Shimada K.

Osteoarthritis Cartilage. 2013 Mar;21(3):514-23. doi: 10.1016/j.joca.2012.12.013. Epub 2013 Jan 4.

4.

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Lakenberg N, van der Breggen R, Storms L, Slagboom PE, Lories RJ, Meulenbelt I.

PLoS One. 2016 May 10;11(5):e0154999. doi: 10.1371/journal.pone.0154999. eCollection 2016.

5.

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ.

Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30.

PMID:
25550340
6.

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.

Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ, Kroon HM, Nakajima M, Ikegawa S, Uitterlinden AG, van Meurs JB, van der Deure WM, Visser TJ, Seymour AB, Lakenberg N, van der Breggen R, Kremer D, van Duijn CM, Kloppenburg M, Loughlin J, Slagboom PE.

Hum Mol Genet. 2008 Jun 15;17(12):1867-75. doi: 10.1093/hmg/ddn082. Epub 2008 Mar 11.

PMID:
18334578
7.

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.

den Hollander W, Ramos YF, Bos SD, Bomer N, van der Breggen R, Lakenberg N, de Dijcker WJ, Duijnisveld BJ, Slagboom PE, Nelissen RG, Meulenbelt I.

Ann Rheum Dis. 2014 Dec;73(12):2208-12. doi: 10.1136/annrheumdis-2014-205980. Epub 2014 Sep 26.

PMID:
25261579
8.

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis.

Waarsing JH, Kloppenburg M, Slagboom PE, Kroon HM, Houwing-Duistermaat JJ, Weinans H, Meulenbelt I.

Arthritis Rheum. 2011 May;63(5):1349-54. doi: 10.1002/art.30288.

9.

Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis.

Liu Q, Zhang X, Dai L, Hu X, Zhu J, Li L, Zhou C, Ao Y.

Arthritis Rheumatol. 2014 Apr;66(4):969-78. doi: 10.1002/art.38309.

10.

Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.

Johnson K, Reynard LN, Loughlin J.

BMC Med Genet. 2015 Sep 7;16:81. doi: 10.1186/s12881-015-0215-9.

11.

SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation.

Aref-Eshghi E, Liu M, Razavi-Lopez SB, Hirasawa K, Harper PE, Martin G, Furey A, Green R, Sun G, Rahman P, Zhai G.

J Rheumatol. 2016 Feb;43(2):388-94. doi: 10.3899/jrheum.150609. Epub 2015 Dec 15.

PMID:
26669923
12.

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients.

Rushton MD, Young DA, Loughlin J, Reynard LN.

Ann Rheum Dis. 2015 Sep;74(9):1778-82. doi: 10.1136/annrheumdis-2014-206752. Epub 2015 Apr 8.

13.

Translating genomics into mechanisms of disease: Osteoarthritis.

Bomer N, den Hollander W, Ramos YF, Meulenbelt I.

Best Pract Res Clin Rheumatol. 2015 Dec;29(6):683-91. doi: 10.1016/j.berh.2016.01.001. Epub 2016 Mar 4. Review.

PMID:
27107506
14.

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.

den Hollander W, Ramos YF, Bomer N, Elzinga S, van der Breggen R, Lakenberg N, de Dijcker WJ, Suchiman HE, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RG, Meulenbelt I.

Arthritis Rheumatol. 2015 May;67(8):2108-16. doi: 10.1002/art.39162.

15.

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.

Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S.

Nat Genet. 2005 Feb;37(2):138-44. Epub 2005 Jan 9.

PMID:
15640800
16.

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway.

Aref-Eshghi E, Liu M, Harper PE, Doré J, Martin G, Furey A, Green R, Rahman P, Zhai G.

Arthritis Res Ther. 2015 Sep 23;17:264. doi: 10.1186/s13075-015-0788-x.

17.

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis.

Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH, Kim HA, Chun CH, Chun JS.

Ann Rheum Dis. 2015 Mar;74(3):595-602. doi: 10.1136/annrheumdis-2013-204355. Epub 2013 Dec 17.

18.

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7.

19.

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, Kawaguchi H.

Hum Mol Genet. 2012 Mar 1;21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17.

PMID:
22095691
20.

Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.

Niebler S, Schubert T, Hunziker EB, Bosserhoff AK.

Arthritis Res Ther. 2015 May 12;17:119. doi: 10.1186/s13075-015-0648-8.

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