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Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways.

Basu D, Lettan R, Damodaran K, Strellec S, Reyes-Mugica M, Rebbaa A.

Mol Cancer Ther. 2014 Jun;13(6):1457-67. doi: 10.1158/1535-7163.MCT-13-0918. Epub 2014 Apr 2.


Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells.

Thacker PC, Karunagaran D.

PLoS One. 2015 Mar 18;10(3):e0120045. doi: 10.1371/journal.pone.0120045. eCollection 2015.


Histone acetylation-mediated regulation of the Hippo pathway.

Basu D, Reyes-Múgica M, Rebbaa A.

PLoS One. 2013 May 6;8(5):e62478. doi: 10.1371/journal.pone.0062478. Print 2013.


Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E71-80. doi: 10.1073/pnas.1517188113. Epub 2015 Dec 22.


AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.

Lin H, Li N, He H, Ying Y, Sunkara S, Luo L, Lv N, Huang D, Luo Z.

Mol Pharmacol. 2015 Dec;88(6):1062-71. doi: 10.1124/mol.115.099549. Epub 2015 Sep 30.


Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Wendt MK, Schiemann WP.

Breast Cancer Res. 2009;11(5):R68. doi: 10.1186/bcr2360. Epub .


An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition.

Park CY, Min KN, Son JY, Park SY, Nam JS, Kim DK, Sheen YY.

Cancer Lett. 2014 Aug 28;351(1):72-80. doi: 10.1016/j.canlet.2014.05.006. Epub 2014 Jun 2.


JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells.

Liu RY, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang HT.

Int J Oncol. 2014 May;44(5):1643-51. doi: 10.3892/ijo.2014.2310. Epub 2014 Feb 21.


Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells.

Jeon MJ, Kim WG, Lim S, Choi HJ, Sim S, Kim TY, Shong YK, Kim WB.

Mol Cell Endocrinol. 2016 Jan 5;419:113-23. doi: 10.1016/j.mce.2015.10.005.


The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer.

Li Z, Wang Y, Zhu Y, Yuan C, Wang D, Zhang W, Qi B, Qiu J, Song X, Ye J, Wu H, Jiang H, Liu L, Zhang Y, Song LN, Yang J, Cheng J.

Mol Oncol. 2015 Jun;9(6):1091-105. doi: 10.1016/j.molonc.2015.01.007. Epub 2015 Feb 9.


Hippo and TGF-β interplay in the lung field.

Saito A, Nagase T.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L756-67. doi: 10.1152/ajplung.00238.2015. Epub 2015 Aug 28. Review.


Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1.

Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL.

Lab Invest. 2014 Apr;94(4):362-70. doi: 10.1038/labinvest.2013.153. Epub 2014 Jan 27.


Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.

Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, Kawachi S, Tanabe M, Shinoda M, Jinno H, Hasegawa H, Kitajima M, Kitagawa Y.

Cancer Sci. 2012 Feb;103(2):317-24. doi: 10.1111/j.1349-7006.2011.02133.x. Epub 2011 Nov 28.


MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer.

Xia H, Ooi LL, Hui KM.

Hepatology. 2013 Aug;58(2):629-41. doi: 10.1002/hep.26369. Epub 2013 Jun 25.


3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Tsai JH, Hsu LS, Lin CL, Hong HM, Pan MH, Way TD, Chen WJ.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):746-56. doi: 10.1016/j.taap.2013.07.019. Epub 2013 Aug 3.


Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.

Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D.

Breast Cancer Res. 2012 Feb 21;14(1):R35.


TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.

Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R.

J Cell Sci. 2012 Mar 1;125(Pt 5):1259-73. doi: 10.1242/jcs.095299. Epub 2012 Mar 7.

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