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AMPKα2 translocates into the nucleus and interacts with hnRNP H: implications in metformin-mediated glucose uptake.

Kim N, Lee JO, Lee HJ, Lee SK, Moon JW, Kim SJ, Park SH, Kim HS.

Cell Signal. 2014 Sep;26(9):1800-6. doi: 10.1016/j.cellsig.2014.03.023. Epub 2014 Mar 29. Erratum in: Cell Signal. 2014 Oct;26(10):2298.


AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn R, Braun U, Leitges M, Farese RV.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E179-92. doi: 10.1152/ajpendo.00392.2009. Epub 2009 Nov 3.


5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

Guigas B, Bertrand L, Taleux N, Foretz M, Wiernsperger N, Vertommen D, Andreelli F, Viollet B, Hue L.

Diabetes. 2006 Apr;55(4):865-74.


Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.

Bogachus LD, Turcotte LP.

Am J Physiol Cell Physiol. 2010 Dec;299(6):C1549-61. doi: 10.1152/ajpcell.00279.2010. Epub 2010 Sep 15.


Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.

Turban S, Stretton C, Drouin O, Green CJ, Watson ML, Gray A, Ross F, Lantier L, Viollet B, Hardie DG, Marette A, Hundal HS.

J Biol Chem. 2012 Jun 8;287(24):20088-99. doi: 10.1074/jbc.M111.330746. Epub 2012 Apr 17.


Tiam-1, a GEF for Rac1, plays a critical role in metformin-mediated glucose uptake in C2C12 cells.

You GY, Lee JO, Kim JH, Kim N, Lee SK, Moon JW, Jie S, Lee HJ, Kim SJ, Park SH, Kim HS.

Cell Signal. 2013 Dec;25(12):2558-65. doi: 10.1016/j.cellsig.2013.08.018. Epub 2013 Aug 29.


Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.

Sakoda H, Ogihara T, Anai M, Fujishiro M, Ono H, Onishi Y, Katagiri H, Abe M, Fukushima Y, Shojima N, Inukai K, Kikuchi M, Oka Y, Asano T.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1239-44.


5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.

Ségalen C, Longnus SL, Baetz D, Counillon L, Van Obberghen E.

Endocrinology. 2008 Apr;149(4):1490-8. doi: 10.1210/en.2007-1326. Epub 2008 Jan 10.


CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.

Abbott MJ, Edelman AM, Turcotte LP.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1724-32. doi: 10.1152/ajpregu.00179.2009. Epub 2009 Oct 7.


Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.

Lee JO, Lee SK, Jung JH, Kim JH, You GY, Kim SJ, Park SH, Uhm KO, Kim HS.

J Cell Physiol. 2011 Apr;226(4):974-81. doi: 10.1002/jcp.22410. Erratum in: J Cell Physiol. 2012 Jun;227(6):2804.


Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. doi: 10.1152/ajpregu.00593.2007. Epub 2008 Jan 16.


Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways.

Jing M, Cheruvu VK, Ismail-Beigi F.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1071-82. doi: 10.1152/ajpcell.00040.2008. Epub 2008 Aug 13.


Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, Geibel JP, Fuerst J, Ritter M.

Cell Physiol Biochem. 2012;29(1-2):75-86. doi: 10.1159/000337589. Epub 2012 Mar 1.


Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

Benziane B, Björnholm M, Pirkmajer S, Austin RL, Kotova O, Viollet B, Zierath JR, Chibalin AV.

J Biol Chem. 2012 Jul 6;287(28):23451-63. doi: 10.1074/jbc.M111.331926. Epub 2012 May 18.


Mediation of AMP kinase in the increase of glucose uptake in L6 cells induced by activation of imidazoline I-2 receptors.

Yang TT, Ku PM, Hsu CT, Chung HH, Lee WJ, Cheng JT.

Horm Metab Res. 2013 May;45(5):359-63. doi: 10.1055/s-0032-1331184. Epub 2012 Dec 7.


Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, Göransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.


[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.

Lee JO, Kim N, Lee HJ, Moon JW, Lee SK, Kim SJ, Kim JK, Park SH, Kim HS.

J Cell Biochem. 2015 Jul;116(7):1401-10. doi: 10.1002/jcb.25100.


Activation of the AMP-activated protein kinase reduces inflammatory nociception.

Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E.

J Pain. 2013 Nov;14(11):1330-40. doi: 10.1016/j.jpain.2013.05.012. Epub 2013 Jul 31.


AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism.

Williamson DL, Butler DC, Alway SE.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E304-14. doi: 10.1152/ajpendo.91007.2008. Epub 2009 Jun 2.

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