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Items: 1 to 20 of 192

1.

Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.

Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T.

J Neurochem. 2014 Aug;130(3):432-43. doi: 10.1111/jnc.12728. Epub 2014 Apr 19.

2.

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z.

Behav Brain Res. 2011 Sep 23;222(2):342-50. doi: 10.1016/j.bbr.2011.03.072. Epub 2011 Apr 14.

PMID:
21513747
3.

Changes in the brain and plasma Aβ peptide levels with age and its relationship with cognitive impairment in the APPswe/PS1dE9 mouse model of Alzheimer's disease.

Izco M, Martínez P, Corrales A, Fandos N, García S, Insua D, Montañes M, Pérez-Grijalba V, Rueda N, Vidal V, Martínez-Cué C, Pesini P, Sarasa M.

Neuroscience. 2014 Mar 28;263:269-79. doi: 10.1016/j.neuroscience.2014.01.003. Epub 2014 Jan 18.

PMID:
24447596
4.

A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.

Jeon S, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.

J Ethnopharmacol. 2011 Sep 1;137(1):783-9. doi: 10.1016/j.jep.2011.06.046. Epub 2011 Jul 5.

PMID:
21762767
5.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
6.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, Sun Y, Yang M, Lim Y, Evin G, Zhong JH, Masters C, Zhou XF.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

7.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

8.

Simvastatin treatment preserves synaptic plasticity in AβPPswe/PS1dE9 mice.

Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE.

J Alzheimers Dis. 2014;39(2):315-29. doi: 10.3233/JAD-130257.

PMID:
24164738
9.

Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.

Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG.

Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1213-21. doi: 10.1007/s00417-009-1060-3. Epub 2009 Mar 7.

PMID:
19271231
10.

Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice.

Balducci C, Tonini R, Zianni E, Nazzaro C, Fiordaliso F, Salio M, Vismara L, Gardoni F, Di Luca M, Carli M, Forloni G.

J Alzheimers Dis. 2010;21(4):1367-81.

PMID:
21504138
11.

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.

Umeda T, Tomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert MP, Klein WL, Mori H.

Life Sci. 2012 Dec 10;91(23-24):1169-76. doi: 10.1016/j.lfs.2011.12.022. Epub 2012 Jan 17.

PMID:
22273754
12.

WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers.

Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC.

Exp Neurol. 2015 Feb;264:14-25. doi: 10.1016/j.expneurol.2014.11.005. Epub 2014 Nov 20.

PMID:
25450465
13.

Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice.

Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE.

Acta Neuropathol Commun. 2015 Sep 4;3:54. doi: 10.1186/s40478-015-0233-z.

14.

Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice.

Sierksma AS, Vanmierlo T, De Vry J, Raijmakers ME, Steinbusch HW, van den Hove DL, Prickaerts J.

Neurochem Int. 2012 Oct;61(5):697-701. doi: 10.1016/j.neuint.2012.06.022. Epub 2012 Jun 29.

PMID:
22750275
15.

Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease.

Xiong H, Callaghan D, Wodzinska J, Xu J, Premyslova M, Liu QY, Connelly J, Zhang W.

Neurosci Bull. 2011 Aug;27(4):221-32. doi: 10.1007/s12264-011-1015-7.

16.

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice.

Toba J, Nikkuni M, Ishizeki M, Yoshii A, Watamura N, Inoue T, Ohshima T.

Biochem Biophys Res Commun. 2016 May 13;473(4):1039-1044. doi: 10.1016/j.bbrc.2016.04.012. Epub 2016 Apr 5.

PMID:
27059136
17.

Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.

Inestrosa NC, Tapia-Rojas C, Griffith TN, Carvajal FJ, Benito MJ, Rivera-Dictter A, Alvarez AR, Serrano FG, Hancke JL, Burgos PV, Parodi J, Varela-Nallar L.

Transl Psychiatry. 2011 Jul 12;1:e20. doi: 10.1038/tp.2011.19.

18.

Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms.

Du Y, Qu J, Zhang W, Bai M, Zhou Q, Zhang Z, Li Z, Miao J.

Neuropharmacology. 2016 Sep;108:1-13. doi: 10.1016/j.neuropharm.2016.04.008. Epub 2016 Apr 8.

PMID:
27067919
19.

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.

J Neurosci. 2002 May 1;22(9):3445-53.

20.

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