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Items: 1 to 20 of 156

1.

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.

Santini R, Pietrobono S, Pandolfi S, Montagnani V, D'Amico M, Penachioni JY, Vinci MC, Borgognoni L, Stecca B.

Oncogene. 2014 Sep 18;33(38):4697-708. doi: 10.1038/onc.2014.71. Epub 2014 Mar 31.

2.

Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells.

Santini R, Vinci MC, Pandolfi S, Penachioni JY, Montagnani V, Olivito B, Gattai R, Pimpinelli N, Gerlini G, Borgognoni L, Stecca B.

Stem Cells. 2012 Sep;30(9):1808-18. doi: 10.1002/stem.1160.

3.

HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.

Pandolfi S, Montagnani V, Lapucci A, Stecca B.

Cell Death Differ. 2015 Dec;22(12):2006-19. doi: 10.1038/cdd.2015.56. Epub 2015 May 29.

4.

Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression.

Gopinath S, Malla R, Alapati K, Gorantla B, Gujrati M, Dinh DH, Rao JS.

Carcinogenesis. 2013 Mar;34(3):550-9. doi: 10.1093/carcin/bgs375. Epub 2012 Dec 7.

5.

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

Pandolfi S, Montagnani V, Penachioni JY, Vinci MC, Olivito B, Borgognoni L, Stecca B.

Oncogene. 2013 Oct;32(40):4737-47. doi: 10.1038/onc.2012.502. Epub 2012 Nov 12.

PMID:
23146903
6.

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F, Ruiz I Altaba A.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5895-900. Epub 2007 Mar 28.

7.

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.

Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A.

Curr Biol. 2007 Jan 23;17(2):165-72. Epub 2006 Dec 28. Erratum in: Curr Biol. 2007 Jan 23;17(2):192.

8.

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.

Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A.

EMBO Mol Med. 2009 Sep;1(6-7):338-51. doi: 10.1002/emmm.200900039.

9.

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma.

Lee SH, Oh SY, Do SI, Lee HJ, Kang HJ, Rho YS, Bae WJ, Lim YC.

Br J Cancer. 2014 Nov 25;111(11):2122-30. doi: 10.1038/bjc.2014.528. Epub 2014 Oct 16.

10.

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, Catanzaro G, Infante P, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I, Locatelli F, Ferretti E.

BMC Cancer. 2017 Jul 17;17(1):488. doi: 10.1186/s12885-017-3477-0.

11.

Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival.

Pietrobono S, Morandi A, Gagliardi S, Gerlini G, Borgognoni L, Chiarugi P, Arbiser JL, Stecca B.

J Invest Dermatol. 2016 Oct;136(10):2059-2069. doi: 10.1016/j.jid.2016.06.610. Epub 2016 Jun 29.

12.

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.

Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J, Zhang S, Hong Y, Yi H, Wu DC, Zhang Y, Wei F, Poh YC, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang B, Wang N.

Nat Commun. 2014 Aug 6;5:4619. doi: 10.1038/ncomms5619.

13.

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Bora-Singhal N, Perumal D, Nguyen J, Chellappan S.

Neoplasia. 2015 Jul;17(7):538-51. doi: 10.1016/j.neo.2015.07.001.

14.

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.

Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM.

Oncogene. 2015 Jun 11;34(24):3107-19. doi: 10.1038/onc.2014.257. Epub 2014 Aug 25.

PMID:
25151964
15.

Selection of tumorigenic melanoma cells using ALDH.

Boonyaratanakornkit JB, Yue L, Strachan LR, Scalapino KJ, LeBoit PE, Lu Y, Leong SP, Smith JE, Ghadially R.

J Invest Dermatol. 2010 Dec;130(12):2799-808. doi: 10.1038/jid.2010.237. Epub 2010 Aug 26.

16.

NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200.

Fu J, Rodova M, Nanta R, Meeker D, Van Veldhuizen PJ, Srivastava RK, Shankar S.

Neuro Oncol. 2013 Jun;15(6):691-706. doi: 10.1093/neuonc/not011. Epub 2013 Mar 12.

17.

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F.

EMBO Mol Med. 2012 Mar;4(3):218-33. doi: 10.1002/emmm.201100201. Epub 2012 Feb 1.

18.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

19.

Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells.

Vazquez-Martin A, Cufí S, López-Bonet E, Corominas-Faja B, Cuyàs E, Vellon L, Iglesias JM, Leis O, Martín AG, Menendez JA.

Cell Cycle. 2013 Nov 15;12(22):3471-7. doi: 10.4161/cc.26692. Epub 2013 Oct 4.

20.

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.

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