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Items: 1 to 20 of 189


A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.

Shinsky SA, Hu M, Vought VE, Ng SB, Bamshad MJ, Shendure J, Cosgrove MS.

J Mol Biol. 2014 Jun 12;426(12):2283-99. doi: 10.1016/j.jmb.2014.03.011. Epub 2014 Mar 27.


An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y.

PLoS One. 2010 Nov 23;5(11):e14102. doi: 10.1371/journal.pone.0014102.


On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

Patel A, Dharmarajan V, Vought VE, Cosgrove MS.

J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25.


Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

Shinsky SA, Monteith KE, Viggiano S, Cosgrove MS.

J Biol Chem. 2015 Mar 6;290(10):6361-75. doi: 10.1074/jbc.M114.627646. Epub 2015 Jan 5.


Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

Alicea-Velázquez NL, Shinsky SA, Loh DM, Lee JH, Skalnik DG, Cosgrove MS.

J Biol Chem. 2016 Oct 21;291(43):22357-22372. Epub 2016 Aug 25.


Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.

Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS.

J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14.


Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS.

J Biol Chem. 2012 Aug 10;287(33):27275-89. doi: 10.1074/jbc.M112.364125. Epub 2012 Jun 3.


A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.

Patel A, Vought VE, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2011 Feb 4;286(5):3359-69. doi: 10.1074/jbc.M110.174524. Epub 2010 Nov 24. Erratum in: J Biol Chem. 2011 May 20;286(20):18344.


Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.

Shinsky SA, Cosgrove MS.

J Biol Chem. 2015 Oct 23;290(43):25819-33. doi: 10.1074/jbc.M115.684142. Epub 2015 Aug 31.


Regulation of MLL1 H3K4 methyltransferase activity by its core components.

Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG.

Nat Struct Mol Biol. 2006 Aug;13(8):713-9. Epub 2006 Jul 30.


A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.

Patel A, Vought VE, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2008 Nov 21;283(47):32162-75. doi: 10.1074/jbc.M806317200. Epub 2008 Oct 1.


Structural basis for activity regulation of MLL family methyltransferases.

Li Y, Han J, Zhang Y, Cao F, Liu Z, Li S, Wu J, Hu C, Wang Y, Shuai J, Chen J, Cao L, Li D, Shi P, Tian C, Zhang J, Dou Y, Li G, Chen Y, Lei M.

Nature. 2016 Feb 25;530(7591):447-52. doi: 10.1038/nature16952. Epub 2016 Feb 17.


A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.

Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Genes Dev. 2015 Jan 15;29(2):123-8. doi: 10.1101/gad.254870.114.


WRAD: enabler of the SET1-family of H3K4 methyltransferases.

Ernst P, Vakoc CR.

Brief Funct Genomics. 2012 May;11(3):217-26. doi: 10.1093/bfgp/els017. Epub 2012 May 30. Review.


Structural and biochemical insights into MLL1 core complex assembly.

Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF.

Structure. 2011 Jan 12;19(1):101-8. doi: 10.1016/j.str.2010.09.022.


Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.

Patel A, Dharmarajan V, Cosgrove MS.

J Biol Chem. 2008 Nov 21;283(47):32158-61. doi: 10.1074/jbc.C800164200. Epub 2008 Oct 1.


Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.

Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF.

FASEB J. 2011 Mar;25(3):960-7. doi: 10.1096/fj.10-171959. Epub 2010 Dec 6.


PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells.

Liu C, Zhang Y, Hou Y, Shen L, Li Y, Guo W, Xu D, Liu G, Zhao Z, Man K, Pan Y, Wang Z, Chen Y.

Biochem J. 2015 May 1;467(3):415-24. doi: 10.1042/BJ20141392.


Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.

Steward MM, Lee JS, O'Donovan A, Wyatt M, Bernstein BE, Shilatifard A.

Nat Struct Mol Biol. 2006 Sep;13(9):852-4. Epub 2006 Aug 6.


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