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Items: 1 to 20 of 274

1.

Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents.

Wang SF, Yin Y, Qiao F, Wu X, Sha S, Zhang L, Zhu HL.

Bioorg Med Chem. 2014 Apr 15;22(8):2409-15. doi: 10.1016/j.bmc.2014.03.004.

PMID:
24680059
2.

Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.

Guo ZH, Yin Y, Wang C, Wang PF, Zhang XT, Wang ZC, Zhu HL.

Bioorg Med Chem. 2015 Sep 15;23(18):6148-56. doi: 10.1016/j.bmc.2015.07.075.

PMID:
26304108
3.

Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents.

Wang SF, Yin Y, Wu X, Qiao F, Sha S, Lv PC, Zhao J, Zhu HL.

Bioorg Med Chem. 2014 Nov 1;22(21):5727-37. doi: 10.1016/j.bmc.2014.09.048.

PMID:
25306465
4.

Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.

Zhang HJ, Zhu DD, Li ZL, Sun J, Zhu HL.

Bioorg Med Chem. 2011 Aug 1;19(15):4513-9. doi: 10.1016/j.bmc.2011.06.021.

PMID:
21741250
5.

Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.

Xiao ZP, Wei W, Wang PF, Shi WK, Zhu N, Xie MQ, Sun YW, Li LX, Xie YX, Zhu LS, Tang N, Ouyang H, Li XH, Wang GC, Zhu HL.

Eur J Med Chem. 2015 Sep 18;102:631-8. doi: 10.1016/j.ejmech.2015.08.025.

PMID:
26318069
6.

3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.

Wang XD, Deng RC, Dong JJ, Peng ZY, Gao XM, Li ST, Lin WQ, Lu CL, Xiao ZP, Zhu HL.

Bioorg Med Chem. 2013 Sep 1;21(17):4914-22. doi: 10.1016/j.bmc.2013.06.066.

PMID:
23891164
7.

Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.

Qin YJ, Wang PF, Makawana JA, Wang ZC, Wang ZN, Yan-Gu, Jiang AQ, Zhu HL.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5279-83.

PMID:
25587588
8.

Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.

Li Y, Zhao CP, Ma HP, Zhao MY, Xue YR, Wang XM, Zhu HL.

Bioorg Med Chem. 2013 Jun 1;21(11):3120-6. doi: 10.1016/j.bmc.2013.03.023.

PMID:
23602519
9.

Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.

Xiao ZP, Ma TW, Liao ML, Feng YT, Peng XC, Li JL, Li ZP, Wu Y, Luo Q, Deng Y, Liang X, Zhu HL.

Eur J Med Chem. 2011 Oct;46(10):4904-14. doi: 10.1016/j.ejmech.2011.07.047.

PMID:
21856050
10.

Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.

Wang XL, Zhang YB, Tang JF, Yang YS, Chen RQ, Zhang F, Zhu HL.

Eur J Med Chem. 2012 Nov;57:373-82. doi: 10.1016/j.ejmech.2012.09.009.

PMID:
23124163
11.

4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.

Xiao ZP, Ouyang H, Wang XD, Lv PC, Huang ZJ, Yu SR, Yi TF, Yang YL, Zhu HL.

Bioorg Med Chem. 2011 Jul 1;19(13):3884-91. doi: 10.1016/j.bmc.2011.05.042.

PMID:
21669535
12.

Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors.

Cheng K, Xue JY, Zhu HL.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4235-8. doi: 10.1016/j.bmcl.2013.05.006.

PMID:
23731945
13.

Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea.

Zhang HJ, Qin X, Liu K, Zhu DD, Wang XM, Zhu HL.

Bioorg Med Chem. 2011 Sep 15;19(18):5708-15. doi: 10.1016/j.bmc.2011.06.077.

PMID:
21872479
14.

Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors.

Li Y, Luo Y, Hu Y, Zhu DD, Zhang S, Liu ZJ, Gong HB, Zhu HL.

Bioorg Med Chem. 2012 Jul 15;20(14):4316-22. doi: 10.1016/j.bmc.2012.05.050.

PMID:
22710102
15.

Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates.

Beena, Kumar N, Rohilla RK, Roy N, Rawat DS.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1396-8. doi: 10.1016/j.bmcl.2009.01.037.

PMID:
19195884
16.

Synthesis, and antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives as DNA gyrase inhibitors.

Liu JJ, Sun J, Fang YB, Yang YA, Jiao RH, Zhu HL.

Org Biomol Chem. 2014 Feb 14;12(6):998-1008. doi: 10.1039/c3ob41953c.

PMID:
24382549
17.

Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.

Tiwari RK, Singh D, Singh J, Chhillar AK, Chandra R, Verma AK.

Eur J Med Chem. 2006 Jan;41(1):40-9.

PMID:
16356593
18.

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation.

Chen LW, Wang PF, Tang DJ, Tao XX, Man RJ, Qiu HY, Wang ZC, Xu C, Zhu HL.

Chem Biol Drug Des. 2016 Oct;88(4):592-8. doi: 10.1111/cbdd.12793.

PMID:
27206529
19.

Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory.

Zhang F, Wen Q, Wang SF, Shahla Karim B, Yang YS, Liu JJ, Zhang WM, Zhu HL.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):90-5. doi: 10.1016/j.bmcl.2013.11.079.

PMID:
24332628
20.

Synthesis and structure-activity relationship of amidine derivatives of 3,4-ethylenedioxythiophene as novel antibacterial agents.

Stolić I, Čipčić Paljetak H, Perić M, Matijašić M, Stepanić V, Verbanac D, Bajić M.

Eur J Med Chem. 2015 Jan 27;90:68-81. doi: 10.1016/j.ejmech.2014.11.003.

PMID:
25461312

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