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Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation.

Wu J, Xu Y, Mo D, Huang P, Sun R, Huang L, Pan S, Xu J.

PLoS One. 2014 Mar 27;9(3):e93478. doi: 10.1371/journal.pone.0093478. eCollection 2014.


Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway.

Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D, Lu C.

Oncogene. 2014 Apr 10;33(15):1986-96. doi: 10.1038/onc.2013.136. Epub 2013 Apr 22.


Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.

Punjabi AS, Carroll PA, Chen L, Lagunoff M.

J Virol. 2007 Mar;81(5):2449-58. Epub 2006 Dec 6.


Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1.

Giffin L, Yan F, Ben Major M, Damania B.

J Virol. 2014 Aug;88(16):9429-41. doi: 10.1128/JVI.00511-14. Epub 2014 Jun 11. Erratum in: J Virol. 2014 Nov;88(21):12932.


The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.

Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M.

Virology. 2012 Jul 5;428(2):112-20. doi: 10.1016/j.virol.2012.03.013. Epub 2012 Apr 21.


HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.

Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J, Hao T, Cheng L, Chen X, Bai Z, Feng N, Gao SJ, Lu C.

PLoS One. 2013;8(1):e53145. doi: 10.1371/journal.pone.0053145. Epub 2013 Jan 2.


Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1.

Hu D, Wang V, Yang M, Abdullah S, Davis DA, Uldrick TS, Polizzotto MN, Veeranna RP, Pittaluga S, Tosato G, Yarchoan R.

J Virol. 2015 Oct 21;90(1):368-78. doi: 10.1128/JVI.01192-15.


Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.

Chen M, Sun F, Han L, Qu Z.

Oncotarget. 2016 May 31;7(22):33363-73. doi: 10.18632/oncotarget.9221.


Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells.

Subramanian R, Sehgal I, D'Auvergne O, Kousoulas KG.

J Virol. 2010 Feb;84(4):1704-14. doi: 10.1128/JVI.01889-09. Epub 2009 Dec 2.


Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.

Hideshima T, Chauhan D, Teoh G, Raje N, Treon SP, Tai YT, Shima Y, Anderson KC.

Clin Cancer Res. 2000 Mar;6(3):1180-9.


A role for virally induced reactive oxygen species in Kaposi's sarcoma herpesvirus tumorigenesis.

Ma Q, Cavallin LE, Leung HJ, Chiozzini C, Goldschmidt-Clermont PJ, Mesri EA.

Antioxid Redox Signal. 2013 Jan 1;18(1):80-90. doi: 10.1089/ars.2012.4584. Epub 2012 Aug 20.


Distinct expression of Kaposi's sarcoma-associated herpesvirus-encoded proteins in Kaposi's sarcoma and multicentric Castleman's disease.

Abe Y, Matsubara D, Gatanaga H, Oka S, Kimura S, Sasao Y, Saitoh K, Fujii T, Sato Y, Sata T, Katano H.

Pathol Int. 2006 Oct;56(10):617-24.


Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease.

Parravicini C, Corbellino M, Paulli M, Magrini U, Lazzarino M, Moore PS, Chang Y.

Am J Pathol. 1997 Dec;151(6):1517-22.


Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.

Sakakibara S, Tosato G.

J Interferon Cytokine Res. 2011 Nov;31(11):791-801. doi: 10.1089/jir.2011.0043. Epub 2011 Jul 18. Review.


Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway.

Lu F, Stedman W, Yousef M, Renne R, Lieberman PM.

J Virol. 2010 Mar;84(6):2697-706. doi: 10.1128/JVI.01997-09. Epub 2010 Jan 13.

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