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Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function.

Zhang Y, Mi SL, Hu N, Doser TA, Sun A, Ge J, Ren J.

Free Radic Biol Med. 2014 Jun;71:208-20. doi: 10.1016/j.freeradbiomed.2014.03.018. Epub 2014 Mar 24.


A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy.

Guo Y, Yu W, Sun D, Wang J, Li C, Zhang R, Babcock SA, Li Y, Liu M, Ma M, Shen M, Zeng C, Li N, He W, Zou Q, Zhang Y, Wang H.

Biochim Biophys Acta. 2015 Feb;1852(2):319-31. doi: 10.1016/j.bbadis.2014.05.017. Epub 2014 May 27.


Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function.

Zhang Y, Babcock SA, Hu N, Maris JR, Wang H, Ren J.

BMC Med. 2012 Apr 23;10:40. doi: 10.1186/1741-7015-10-40.


AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction.

Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, Ren J.

Aging Cell. 2010 Aug;9(4):592-606. doi: 10.1111/j.1474-9726.2010.00586.x. Epub 2010 May 10.


Mitochondrial aldehyde dehydrogenase obliterates endoplasmic reticulum stress-induced cardiac contractile dysfunction via correction of autophagy.

Zhang B, Zhang Y, La Cour KH, Richmond KL, Wang XM, Ren J.

Biochim Biophys Acta. 2013 Apr;1832(4):574-84. doi: 10.1016/j.bbadis.2013.01.013. Epub 2013 Jan 23.


AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol.

Ge W, Guo R, Ren J.

Free Radic Biol Med. 2011 Nov 1;51(9):1736-48. doi: 10.1016/j.freeradbiomed.2011.08.002. Epub 2011 Aug 10.


Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.

Sun A, Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Takano H, Ping P, Komuro I, Ge J.

J Am Heart Assoc. 2014 Sep 18;3(5):e000779. doi: 10.1161/JAHA.113.000779.


Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1.

Wu B, Yu L, Wang Y, Wang H, Li C, Yin Y, Yang J, Wang Z, Zheng Q, Ma H.

Oncotarget. 2016 Jan 19;7(3):2175-88. doi: 10.18632/oncotarget.6814.


Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance.

Gu C, Xing Y, Jiang L, Chen M, Xu M, Yin Y, Li C, Yang Z, Yu L, Ma H.

PLoS One. 2013 Sep 10;8(9):e74050. doi: 10.1371/journal.pone.0074050. eCollection 2013.


Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor.

Ma H, Li J, Gao F, Ren J.

J Am Coll Cardiol. 2009 Dec 1;54(23):2187-96. doi: 10.1016/j.jacc.2009.04.100.


Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat.

Tang Y, Mi C, Liu J, Gao F, Long J.

Cardiovasc Pathol. 2014 Mar-Apr;23(2):101-6. doi: 10.1016/j.carpath.2013.11.002. Epub 2013 Nov 14.


Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

Doser TA, Turdi S, Thomas DP, Epstein PN, Li SY, Ren J.

Circulation. 2009 Apr 14;119(14):1941-9. doi: 10.1161/CIRCULATIONAHA.108.823799. Epub 2009 Mar 30.


Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy.

Sun A, Cheng Y, Zhang Y, Zhang Q, Wang S, Tian S, Zou Y, Hu K, Ren J, Ge J.

J Mol Cell Cardiol. 2014 Jun;71:92-104. doi: 10.1016/j.yjmcc.2014.01.002. Epub 2014 Jan 13.


Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases.

Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J.

J Mol Cell Cardiol. 2010 Aug;49(2):322-9. doi: 10.1016/j.yjmcc.2010.03.017. Epub 2010 Apr 1.


Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde.

Ma H, Guo R, Yu L, Zhang Y, Ren J.

Eur Heart J. 2011 Apr;32(8):1025-38. doi: 10.1093/eurheartj/ehq253. Epub 2010 Aug 12.


Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.

Cardiovasc Res. 2014 Sep 1;103(4):498-508. doi: 10.1093/cvr/cvu125. Epub 2014 May 9.


Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart.

Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, Liu Y, Lian K, Yang L, Sun L, Guo Y, Zhang L, Dong L, Lau WB, Gao E, Gao F, Xiong L, Wang H, Qu Y, Tao L.

Basic Res Cardiol. 2013 May;108(3):329. doi: 10.1007/s00395-013-0329-1. Epub 2013 Mar 5.


Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging.

Zhang Y, Wang C, Zhou J, Sun A, Hueckstaedt LK, Ge J, Ren J.

Biochim Biophys Acta. 2017 Aug;1863(8):1919-1932. doi: 10.1016/j.bbadis.2017.03.016. Epub 2017 Mar 27.


Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.

Gomes KM, Bechara LR, Lima VM, Ribeiro MA, Campos JC, Dourado PM, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.

Int J Cardiol. 2015 Jan 20;179:129-38. doi: 10.1016/j.ijcard.2014.10.140. Epub 2014 Oct 23.

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